AutismKB 2.0

Annotation Detail for USP9X


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Basic Information Top
Gene Symbol:USP9X ( DFFRX,FAF,FAM )
Gene Full Name: ubiquitin specific peptidase 9, X-linked
Band: Xp11.4
Quick LinksEntrez ID:8239; OMIM: 300072; Uniprot ID:USP9X_HUMAN; ENSEMBL ID: ENSG00000124486; HGNC ID: 12632
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of USP9X mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of USP9X mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of USP9X mRNAincreases expression 15336504
D005472 Fluorouracil USP9X protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C002950 methylformamide methylformamide analog results in increased expression of USP9X mRNAincreases expression 17040096
C002950 methylformamide methylformamide results in increased expression of USP9X mRNAincreases expression 17040096
D012643 Selenium Selenium results in decreased expression of USP9X mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of USP9X mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D000740 Anemia Fluorouracil 3.9817963324 16511603 15504547
MESH:D001943 Breast Neoplasms Fluorouracil 2.4416557594 18357371 19217205 16595493 18608205 16110121 15136595
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1116051944
MESH:D002277 Carcinoma Fluorouracil 3.7917121937
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1916705839
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.1917971768 17088986 18930000 16799960 16332177 17045692
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5516280240 16757204 17066447 18986760
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.266135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2716510598 17172411 18772588 17287894 16340194 17725105 17016597 15001691 17169374 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015148649 17594712 17255274 14970324 18509181 18383874 16331619 15289873 18949393 20501625 17401013 17016601 18288408 18448328 17094418 16391804 17454858 17695437 16303861 16524972 18802399 16282729
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D007644 Darier Disease Fluorouracil 5.1916733453
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1615131321
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7120426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7117638652 16481741 16785472 15173087 16337965
MESH:D005910 Glioma Fluorouracil 2.9616145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5618337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D007251 Influenza, Human Selenium 12.4816624496
MESH:D007251 Influenza, Human Vitamin E 12.4816624496
MESH:D007674 Kidney Diseases Vitamin E 2.9512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms Fluorouracil 8.2716985049
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.947678174
MESH:D008113 Liver Neoplasms Fluorouracil 4.9417045692 18383874 16603448 15113037
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.706135515 2876786 2876784
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Fluorouracil 2.6515246190
MESH:D008175 Lung Neoplasms Vitamin E 2.6511062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1915086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8416757204 18986760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009369 Neoplasms Fluorouracil 2.7218600527 16928823 18239605
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6116436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7416929163 19003803 15113037 16500647
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2919082440 18626508
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2915084515
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2616160472 15538739 18286688 18722050
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.808532709
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 16951190 16424979 15786421 17498489 19084572 17172411 18396642 19015929 18567086
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2516280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1416803524
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37257
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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