AutismKB 2.0

Annotation Detail for CAPN2


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Basic Information Top
Gene Symbol:CAPN2 ( CANP2,CANPL2,CANPml,FLJ39928,mCANP )
Gene Full Name: calpain 2, (m/II) large subunit
Band: 1q41
Quick LinksEntrez ID:824; OMIM: 114230; Uniprot ID:CAN2_HUMAN; ENSEMBL ID: ENSG00000162909; HGNC ID: 1479
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa05010Alzheimer's disease
hsa04510Focal adhesion
hsa04210Apoptosis
No data
Pathway IDPathway Name
200113ErbB1 downstream signaling
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1734Muscular dystrophy
1944Breast cancer
2062Neurodegenerative disorder
1882Malaria
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CAPN2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CAPN2 mRNAaffects expression 21346803
C026729 4-aminophenol 4-aminophenol results in decreased activity of CAPN2 proteindecreases activity 17567590
C026729 4-aminophenol 4-aminophenol results in decreased expression of CAPN2 proteindecreases expression 17567590
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CAPN2 mRNAdecreases expression 12419474
D020106 Acrylamide Acrylamide results in increased expression of CAPN2 mRNAincreases expression 15749267
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CAPN2 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in decreased expression of CAPN2 mRNAdecreases expression 17460283
C068073 Am 580 Am 580 inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]decreases reaction|increases activity 17460283
C068073 Am 580 Am 580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]decreases reaction|increases expression 17460283
C068073 Am 580 Am 580 results in decreased activity of CAPN2 proteindecreases activity 17460283
C068073 Am 580 Am 580 results in decreased expression of CAPN2 mRNAdecreases expression 17460283
C010680 antibiotic G 418 antibiotic G 418 results in increased cleavage of CAPN2 proteinincreases cleavage 15241557
C006632 arsenic trioxide arsenic trioxide results in increased expression of CAPN2 proteinincreases expression 19695276
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CAPN2 mRNAincreases expression 20106945
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene affects the expression of CAPN2 proteinaffects expression 7716780
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CAPN2 mRNAdecreases expression 12419474
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased cleavage of CAPN2 proteinincreases cleavage 16920763
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of CAPN2 proteinincreases expression 16920763
D002246 Carbon Disulfide Carbon Disulfide results in decreased expression of CAPN2 proteindecreases expression 17120161
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of CAPN2 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in increased expression of CAPN2 mRNAincreases expression 20106945
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of CAPN2 mRNAaffects cotreatment|affects expression 17330099
D002945 Cisplatin Cisplatin results in decreased activity of CAPN2 proteindecreases activity 17567590
D002945 Cisplatin Cisplatin results in decreased expression of CAPN2 proteindecreases expression 17567590
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of CAPN2 mRNAincreases expression 17547211
C056933 fumonisin B1 fumonisin B1 results in increased expression of CAPN2 mRNAincreases expression 16221962
D005839 Gentamicins Gentamicins results in decreased expression of CAPN2 proteindecreases expression 17567590
C071834 glycidamide glycidamide results in decreased expression of CAPN2 mRNAdecreases expression 17822822
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CAPN2 mRNAdecreases expression 12419474
D006861 Hydrogen Peroxide Am 580 inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]decreases reaction|increases activity 17460283
D006861 Hydrogen Peroxide Am 580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]decreases reaction|increases expression 17460283
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased activity of CAPN2 proteinincreases activity 17460283
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of CAPN2 mRNAincreases expression 17460283
D006861 Hydrogen Peroxide Tretinoin inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]decreases reaction|increases activity 17460283
D006861 Hydrogen Peroxide Tretinoin inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]decreases reaction|increases expression 17460283
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of CAPN2 proteinincreases expression 17570061
D006861 Hydrogen Peroxide Indomethacin inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein]decreases reaction|increases expression 17570061
D006861 Hydrogen Peroxide Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein]decreases reaction|increases expression 17570061
D007213 Indomethacin Indomethacin results in decreased activity of CAPN2 proteindecreases activity 11071371
D007213 Indomethacin Indomethacin inhibits the reaction [CAPN2 protein results in increased degradation of MBP protein]decreases reaction|increases degradation 11071371
D007213 Indomethacin Indomethacin inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein]decreases reaction|increases expression 17570061
D007460 Iodoacetamide Iodoacetamide results in increased cleavage of CAPN2 proteinincreases cleavage 16920763
D007460 Iodoacetamide Iodoacetamide results in increased expression of CAPN2 proteinincreases expression 16920763
D020910 Ketorolac Ketorolac results in decreased activity of CAPN2 proteindecreases activity 11071371
D008770 Methylnitrosourea Methylnitrosourea results in increased activity of CAPN2 proteinincreases activity 17069801
D008775 Methylprednisolone Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein]decreases reaction|increases expression 17570061
D005996 Nitroglycerin Nitroglycerin results in decreased expression of CAPN2 mRNAdecreases expression 12102619
C093973 PD 98059 PD 98059 inhibits the reaction [EGF protein affects the localization of and results in increased activity of CAPN2 protein]affects localization|decreases reaction|increases activity 16809781
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of CAPN2 mRNAdecreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of CAPN2 mRNAincreases expression 16221962
18301758
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of CAPN2 mRNA]affects reaction|increases expression 16221962
D019269 Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol 4,5-Diphosphate affects the reaction [EGF protein results in increased activity of CAPN2 protein]affects reaction|increases activity 16809781
D019269 Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol 4,5-Diphosphate binds to CAPN2 proteinaffects binding 16809781
D020849 Raloxifene Raloxifene affects the expression of CAPN2 mRNAaffects expression 14699072
C017947 sodium arsenite sodium arsenite results in decreased expression of CAPN2 mRNAdecreases expression 12760830
D013629 Tamoxifen Tamoxifen affects the expression of CAPN2 mRNAaffects expression 14699072
C004648 testosterone enanthate testosterone enanthate affects the expression of CAPN2 mRNAaffects expression 17440010
D014212 Tretinoin Tretinoin inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]decreases reaction|increases activity 17460283
D014212 Tretinoin Tretinoin inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]decreases reaction|increases expression 17460283
D014212 Tretinoin Tretinoin results in decreased activity of CAPN2 proteindecreases activity 17460283
D014212 Tretinoin Tretinoin results in decreased expression of CAPN2 mRNAdecreases expression 17460283
D024483 Vitamin K 3 Vitamin K 3 results in increased cleavage of CAPN2 proteinincreases cleavage 16920763
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of CAPN2 proteinincreases expression 16920763
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of CAPN2 mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1214745880
MESH:D058186 Acute Kidney Injury Cisplatin 7.9017670903 15814532 12690470
MESH:D058186 Acute Kidney Injury Gentamicins 7.9011274264
MESH:D055371 Acute Lung Injury pirinixic acid 2.7318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 15.5411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.5420464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 15.5417638652 11798837
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 15.5416033868
MESH:D000230 Adenocarcinoma Indomethacin 15.5416537180
MESH:D000230 Adenocarcinoma Methylnitrosourea 15.5415688392 15113128
MESH:D000236 Adenoma Benzo(a)pyrene 9.866695378
MESH:D000236 Adenoma Dimethylnitrosamine 9.8619555203
MESH:D000236 Adenoma Indomethacin 9.8611497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.0616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4717306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.2017451421 17308373
MESH:D000505 Alopecia Tretinoin 3.2815955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9417225004
MESH:D000544 Alzheimer Disease Indomethacin 4.1017627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 4.1015800139
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.8410965797
MESH:D001014 Aortic Aneurysm Indomethacin 4.4510231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.3519183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.3510388637
MESH:D018771 Arthralgia Indomethacin 4.742160914
MESH:D001169 Arthritis, Experimental Tretinoin 2.8116412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.3811248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.3816292516
MESH:D001249 Asthma Tretinoin 2.2116456186
MESH:D050197 Atherosclerosis Carbon Disulfide 4.6710367350 10658303
MESH:D001471 Barrett Esophagus Tretinoin 4.0016935849
MESH:D001477 Bartter Syndrome Indomethacin 4.5710684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.1916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.1919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.1916197459 16206674
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.4614601052
MESH:D001929 Brain Edema Indomethacin 4.6011481608
MESH:D001930 Brain Injuries Raloxifene 4.0716580743
MESH:D002545 Brain Ischemia Indomethacin 4.0012524144
MESH:D001943 Breast Neoplasms Acrylamide 7.6916253758 18183576
MESH:D001943 Breast Neoplasms alitretinoin 7.6916344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.6917474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 7.6919526202 18382427
MESH:D001943 Breast Neoplasms decitabine 7.6918320071 19208741
MESH:D001943 Breast Neoplasms Indomethacin 7.6917401462
MESH:D001943 Breast Neoplasms Methylnitrosourea 7.6916253758 11306469 14633655
MESH:D001943 Breast Neoplasms Raloxifene 7.6917049068 16837676 15758505 17242785 17440819 17261762 17893378 16912660 15572757 17952589 15775269 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 7.6919410462 20065188 19103187 19155303 17261762 19244106 21152245 19011961 19200415 16202921 21138602 11161223 18984771 16273361 20005174 19142967 18821012 19066611 20390343 18351453 18997820 19059307 19288272 20135344 17049068 19189212 18425577 16818667 19289846 17242785 19487384 19189210 15565566 18629630 16873071 18855134 20544844 19084267 20859285 17440819 15668708 19115204 19221464 18815881 17893378
MESH:D001943 Breast Neoplasms Tretinoin 7.6916166294 16443354 16873071
MESH:D001943 Breast Neoplasms vorinostat 7.6916144943
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1716813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9411589617
MESH:D002056 Burns Indomethacin 4.3010459503
MESH:D002100 Cachexia Indomethacin 4.5915141370 11239499 15625704 16537180
MESH:D002277 Carcinoma Dimethylnitrosamine 3.6919555203
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.2816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.2816705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.2812619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 18.2814691202 15553829 16217749 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 18.2817982673
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 18.2816391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.2815276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 18.2816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 18.281917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9311352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.8812023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4519014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1717341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 19.8820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 19.8817066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 19.8819215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 19.8816033868
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 19.8815482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 19.8818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 19.8816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.2917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.2917572228
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.6116936243
MESH:D002318 Cardiovascular Diseases Raloxifene 6.6115775269
MESH:D002386 Cataract Am 580 11.1917460283
MESH:D002386 Cataract Methylnitrosourea 11.1912484553
MESH:D002386 Cataract Tretinoin 11.1917460283
MESH:D002418 Cattle Diseases Acrylamide 5.0212510666
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 13.676135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.6712371664
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 13.677505956 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.6719524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1716129372
MESH:D002764 Cholecystitis Indomethacin 4.7411181007
MESH:D002779 Cholestasis Cyclosporine 6.7219486331
MESH:D002779 Cholestasis pirinixic acid 6.7219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7316461808
MESH:D002972 Cleft Palate Tretinoin 2.499407595
MESH:D003072 Cognition Disorders Raloxifene 4.2115800139
MESH:D003092 Colitis Am 580 8.5717035595
MESH:D003092 Colitis Tretinoin 8.5717035595
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.5020423518
MESH:D003110 Colonic Neoplasms decitabine 3.7017616700
MESH:D003110 Colonic Neoplasms Indomethacin 3.7015936596 11260862 15786552 15637740 15625704 15963497
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.4420501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.4415273666
MESH:D015179 Colorectal Neoplasms decitabine 4.4418981723
MESH:D015179 Colorectal Neoplasms Indomethacin 4.4417054584 12606626 18059344 11197048
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7912609071
MESH:D018352 Coronavirus Infections Indomethacin 5.2917302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.539142499 17551590 8800419 10589399 16925845 9664655 9211117 14991402 9224671 9125849
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.5318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.5318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7115213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8117474826
MESH:D017449 Dermatitis, Allergic Contact 4-aminophenol 5.0411906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003882 Dermatomyositis Methylprednisolone 5.9920191521
MESH:D003928 Diabetic Nephropathies Raloxifene 7.8717451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.8719279558
MESH:D003967 Diarrhea Indomethacin 7.267907874 7237001
MESH:D003967 Diarrhea vorinostat 7.2620479100
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 10.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 10.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 10.5617654400
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 10.568172417
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 10.5616221962
MESH:D004362 Drug Toxicity Cisplatin 7.7612231392 15033597 12649298 19839026
MESH:D004362 Drug Toxicity Gentamicins 7.7611033412 15033597
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7318446180 18043480 16326151 16133044 12774134 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.7417351913 16699067 11991626 10671773 17151854 17202747 17329845 11595431 11535926 11595415 17045617
MESH:D004487 Edema Indomethacin 9.447907874 10653021 16100529 7990266 8273558 8985016 19703484
MESH:D004487 Edema pirinixic acid 9.4412083418
MESH:D004487 Edema Raloxifene 9.4415860553
MESH:D004489 Edema, Cardiac Tretinoin 4.0418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 7.9315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.9319031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6919294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.5116202921 20544844 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 6.5116569247
MESH:D004715 Endometriosis Indomethacin 3.7815652904
MESH:D019446 Endotoxemia Indomethacin 4.0818509659
MESH:D004751 Enteritis Indomethacin 4.3210567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5717980183
MESH:D004802 Eosinophilia Indomethacin 3.6511298111
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.5212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.5216530937
MESH:D004938 Esophageal Neoplasms Cisplatin 12.5215173087 16481741 17638652 15464296 16785472
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 12.5217016578
MESH:D004938 Esophageal Neoplasms Indomethacin 12.5211005569
MESH:D005124 Eye Abnormalities Tretinoin 3.2616938888 9664655
MESH:D005128 Eye Diseases Ketorolac 6.6511084241
MESH:D005221 Fatigue vorinostat 5.1820479100
MESH:D005234 Fatty Liver arsenic trioxide 20.6915073043
MESH:D005234 Fatty Liver Cyclosporine 20.6919224547
MESH:D005234 Fatty Liver pirinixic acid 20.6919236843 20131406
MESH:D005234 Fatty Liver Raloxifene 20.6917473493
MESH:D005234 Fatty Liver Tamoxifen 20.6914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9816709447
MESH:D005334 Fever Indomethacin 3.7610431976 17627676 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7619069698
MESH:D005354 Fibrosarcoma Indomethacin 10.8110962813
MESH:D005354 Fibrosarcoma Methylnitrosourea 10.8111555667
MESH:D005355 Fibrosis Cyclosporine 12.5112639820 12168785
MESH:D005355 Fibrosis Indomethacin 12.5117994277
MESH:D005355 Fibrosis Tretinoin 12.5117994277
MESH:D005499 Folliculitis Indomethacin 4.7411298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8616904648
MESH:D005756 Gastritis Indomethacin 10.6915046732
MESH:D005756 Gastritis Iodoacetamide 10.6915046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.808708960
MESH:D005909 Glioblastoma Indomethacin 6.4012870263
MESH:D005909 Glioblastoma Tretinoin 6.4017312396
MESH:D005910 Glioma Indomethacin 5.9116487511 18371953
MESH:D005910 Glioma Methylnitrosourea 5.919825942
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9511849393
MESH:D006073 Gout Indomethacin 4.9311248219
MESH:D006261 Headache Nitroglycerin 4.7611284996 11554966
MESH:D006258 Head and Neck Neoplasms Cisplatin 16.1415464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 16.1419215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 16.1415482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 16.1416096774
MESH:D034381 Hearing Loss Cisplatin 9.1219898482
MESH:D034381 Hearing Loss Gentamicins 9.1219130971 18024279 17868369 15968427
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7316084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0815464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 5.899664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.2411110106
MESH:D006333 Heart Failure pirinixic acid 2.2820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0015720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1915633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2815135802
MESH:D006529 Hepatomegaly fumonisin B1 7.4216221962
MESH:D006529 Hepatomegaly pirinixic acid 7.4216221962 18467677 19176532 19772884
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3217440010
MESH:D006689 Hodgkin Disease Cisplatin 6.3916170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.3912676792
MESH:D006930 Hyperalgesia Indomethacin 6.9312727271
MESH:D006930 Hyperalgesia Tretinoin 6.9316870215
MESH:D034321 Hyperamylasemia Indomethacin 5.2917883296
MESH:D053565 Hypercalciuria Gentamicins 5.2917652376
MESH:D006940 Hyperemia Indomethacin 4.5912524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1616778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8220558911
MESH:D006949 Hyperlipidemias Indomethacin 3.7817546600
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.1517604070
MESH:D006973 Hypertension Cyclosporine 4.7210903974
MESH:D006973 Hypertension Raloxifene 4.7217577099 15787275
MESH:D007077 Ileal Diseases Indomethacin 4.6018306037 10574470
MESH:D007079 Ileitis Indomethacin 4.9310651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9416133044
MESH:D007247 Infertility, Female Acrylamide 4.8211020651
MESH:D007248 Infertility, Male Acrylamide 13.8512507653 15355880 11020651 15749267
MESH:D007248 Infertility, Male decitabine 13.8517581917
MESH:D007248 Infertility, Male Methylnitrosourea 13.857193160
MESH:D007248 Infertility, Male sodium arsenite 13.8512646999 15346721
MESH:D007249 Inflammation Indomethacin 4.563291741 12568917 7812673
MESH:D007249 Inflammation Tamoxifen 4.5619457130
MESH:D007333 Insulin Resistance pirinixic acid 2.3616306350
MESH:D007410 Intestinal Diseases Indomethacin 8.5315610444 11686837 17994277 15831440 18236018 11855677 10210152 11713966 17329856
MESH:D007410 Intestinal Diseases Tretinoin 8.5317994277
MESH:D019586 Intracranial Hypertension Indomethacin 4.9415241188
MESH:D007569 Jaw Abnormalities Tretinoin 3.5315992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.6010574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0115604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2216144296
MESH:D007673 Kidney Cortex Necrosis Cisplatin 11.9015464296
MESH:D007673 Kidney Cortex Necrosis Gentamicins 11.9018842672
MESH:D007674 Kidney Diseases Cisplatin 16.4512231392 18289764 19839026 12649298 15190930
MESH:D007674 Kidney Diseases Cyclosporine 16.4510903974 18776723 8314463
MESH:D007674 Kidney Diseases Gentamicins 16.4519349640 18289764 17934191
MESH:D007674 Kidney Diseases Indomethacin 16.4517190690
MESH:D007674 Kidney Diseases sodium arsenite 16.4520008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.9016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.9616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.9616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.9612371664
MESH:D007680 Kidney Neoplasms Tamoxifen 14.9618625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 10.5911231351
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 10.5911231351
MESH:D007889 Leiomyoma Raloxifene 4.1116973256
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 7.7510219319
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 7.7511703811 10320625 12228301
MESH:D007938 Leukemia arsenic trioxide 9.2315070760
MESH:D007938 Leukemia decitabine 9.2318980019 19235587
MESH:D007938 Leukemia Tretinoin 9.2317143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Methylprednisolone 4.6914551737
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 10.3316972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 10.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.5214633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.5215631656 16572323 10785260
MESH:D007951 Leukemia, Myeloid arsenic trioxide 13.8419077051
MESH:D007951 Leukemia, Myeloid decitabine 13.8417236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 13.8419285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.0216968895 20471514 19850784 17050201 16467208
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.0218206229 18460780 19010910 17679729 19387464 18704418
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 8.0218360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.0216294345 19850784 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0318055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.719834237 16331271 16823087 11161223 15213294 15336539 17107899 16330433 12712474 16966277 19035177 19225113 17217047 17869043 11468182 15748426 17649720 12679006 16112521 15622746 16891316 19075265 12018890 17712046 19642359
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.7116823087 16788101 17294898 16766008 17301526 19035177 16891316 16331271 17361223 17712046 16935935 19642359 17649720 19075265 17217047 15748426 19029980 17339181 17506722 17107899 12679006 9834237 16140955 17368321 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9516882451
MESH:D007964 Leukocytosis Indomethacin 4.9416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2917980183
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.4615526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.469224671
MESH:D008064 Lipidoses Tamoxifen 2.8617567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2911479899
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.0912925901 15793283 17881167 15161499 14659978 15733078 17348192 15842777 15099470 17201889 17465448 18237412 15479170 16603200 18672772 14643895 14709902 15723089 17719030 15591649 16544323 14726149 15298665 15369754 18210741 17724770 17196135 15339415 15864749 15366600 15138612 18637143 16009107 15504291 15577212 18629640 17666798 18567088 15942678 12918455 17036385 15798949 14568256 17203207 16169303 18371158 15081153 15383259 17198567 16570917 18095165 15571005 15763062 16270385 15492853 15086199 15067225 15744066 17432682 17640959 16627068 17534399 18364076 18239293 16042886
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.0918194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.0915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.0918564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.0918397230 16248980
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.0417457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 26.707678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 26.709163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 26.7014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.7021137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 26.7018177683
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 26.7015890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 26.7020007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 26.7016712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 26.7016684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 11.972876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.978603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.9720377131
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 11.976150874 1848544 15603536
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0315213294
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.0516080182
MESH:D008171 Lung Diseases sodium arsenite 2.8919095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 19.0514755239
MESH:D008175 Lung Neoplasms alitretinoin 19.0516413115
MESH:D008175 Lung Neoplasms arsenic trioxide 19.0519825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.0518520028 17053015 6695378 20464547 20869020 18816296 20064080 18569708 20135361
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 19.0519925653 15390079 11696405 11246140 18597497 16337739 19359593
MESH:D008175 Lung Neoplasms Cisplatin 19.0511798837 17225452 6189445
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 19.0516061637 11884234 19555203
MESH:D008175 Lung Neoplasms Indomethacin 19.0511053908 11497255 16537180
MESH:D008175 Lung Neoplasms Methylnitrosourea 19.0518062963
MESH:D008175 Lung Neoplasms sodium arsenite 19.0517306315 16712894 15276417 19931552 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 19.0518625569
MESH:D008223 Lymphoma decitabine 6.9319470736
MESH:D008223 Lymphoma Methylnitrosourea 6.9311418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.3914633661
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.2720479100
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3419428831
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 8.641500032
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 8.6416827153 14999141 17131329 16944150 15688392 15313902 16051031 11751437 16619500 11807958 19196723 15113128 10767621 17020996 10838139 14633655 12931682
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.6419196723 14580682 16827153 19196722 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.1219453300
MESH:D008527 Medulloblastoma Tretinoin 2.6117453147
MESH:D008545 Melanoma Cisplatin 11.3516248763 16432458 18505091 15577323 17761969 18176117 17023156 11135225 16809738 12883367 12374674 18332650 12393984
MESH:D008545 Melanoma decitabine 11.3517785578 16505122
MESH:D008545 Melanoma sodium arsenite 11.3516487513 19082730
MESH:D008545 Melanoma Tamoxifen 11.3512393984 19393235
MESH:D008545 Melanoma Tretinoin 11.3516752155
MESH:D008545 Melanoma Vitamin K 3 11.3519082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.1115990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.1115990972
MESH:D008591 Meningomyelocele Tretinoin 4.0216940565
MESH:D008654 Mesothelioma Cisplatin 3.0717638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3616801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.353537620
MESH:D008881 Migraine Disorders Indomethacin 3.3811903285
MESH:D020326 Migraine without Aura Nitroglycerin 4.7314659530
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1315863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.5916381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.5912636206
MESH:D009101 Multiple Myeloma arsenic trioxide 10.4311468182 14977855 19417148 15949261 19549372
MESH:D009101 Multiple Myeloma decitabine 10.4318172295
MESH:D009101 Multiple Myeloma Raloxifene 10.4316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1016239165
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.8518694830
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.9116105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 10.9119157545 16882708 18608210 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.9117596541
MESH:D009203 Myocardial Infarction Nitroglycerin 5.3914729435
MESH:D009203 Myocardial Infarction pirinixic acid 5.3919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6316411023
MESH:D009232 Myxoma Raloxifene 5.1316343187
MESH:D009325 Nausea vorinostat 5.1020479100
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.9518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.957678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5616624393
MESH:D009362 Neoplasm Metastasis Indomethacin 5.3516537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3719410462
MESH:D009369 Neoplasms alitretinoin 24.5816946489
MESH:D009369 Neoplasms Benzo(a)pyrene 24.5811141357
MESH:D009369 Neoplasms Cisplatin 24.5816773208
MESH:D009369 Neoplasms decitabine 24.5819470736 17925555 19116145
MESH:D009369 Neoplasms Methylnitrosourea 24.5815533788
MESH:D009369 Neoplasms pirinixic acid 24.5817405874
MESH:D009369 Neoplasms sodium arsenite 24.5811559025
MESH:D009369 Neoplasms Tretinoin 24.5816594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 13.0615625704 10663608
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 13.0612696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 13.0620056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5719196722 19189210 19200415
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0715464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9319348381 18481113
MESH:D009410 Nerve Degeneration Acrylamide 4.3711264303 12387366 12387367
MESH:D009422 Nervous System Diseases Acrylamide 9.3912164553 12507653
MESH:D009422 Nervous System Diseases Carbon Disulfide 9.3910669001
MESH:D009421 Nervous System Malformations Tretinoin 3.389125849
MESH:D009436 Neural Tube Defects arsenic trioxide 10.5410525206
MESH:D009436 Neural Tube Defects sodium arsenite 10.5412854658
MESH:D009436 Neural Tube Defects Tretinoin 10.549142499
MESH:D009442 Neurilemmoma Methylnitrosourea 5.0711555667
MESH:D009447 Neuroblastoma Cisplatin 3.238761367
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.6012349958
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.288761367
MESH:D020258 Neurotoxicity Syndromes Carbon Disulfide 5.0215315294
MESH:D009765 Obesity pirinixic acid 1.7020558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.746374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.6812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.6816049721
MESH:D010003 Osteoarthritis Indomethacin 3.417009135
MESH:D010024 Osteoporosis Raloxifene 3.1319059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8417823083 17893378 15758505 15579764
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.4116624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 13.4115464296 19769630 6897625 17225452
MESH:D010051 Ovarian Neoplasms decitabine 13.4119259094 19331143
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.4115276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 13.4116936753
MESH:D010146 Pain Indomethacin 5.8717440234 17627676 13679232 3291741
MESH:D010146 Pain Tretinoin 5.8716870215
MESH:D010149 Pain, Postoperative Indomethacin 10.4512538197 18702446
MESH:D010149 Pain, Postoperative Methylprednisolone 10.4512538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.5815580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 14.5819003803
MESH:D010190 Pancreatic Neoplasms decitabine 14.5819294695
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 14.5816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.5815976015
MESH:D010195 Pancreatitis Indomethacin 3.5415028970 17883296
MESH:D010212 Papilloma Hydrogen Peroxide 3.6812065085
MESH:D010235 Paraganglioma arsenic trioxide 3.7819927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2916537180
MESH:D020734 Parkinsonian Disorders Carbon Disulfide 8.7515019297
MESH:D020734 Parkinsonian Disorders Indomethacin 8.7512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2911903285
MESH:D010437 Peptic Ulcer Indomethacin 4.7311148446
MESH:D010518 Periodontitis Indomethacin 4.4917225004
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 9.0811510240
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 9.0815464296
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.0811550810
MESH:D010997 Pleural Neoplasms Cisplatin 4.9217638057
MESH:D011014 Pneumonia Butylated Hydroxytoluene 4.7411893704
MESH:D017499 Porokeratosis alitretinoin 5.5816144296
MESH:D011230 Precancerous Conditions Cyclosporine 2.8712371664
MESH:D047928 Premature Birth Indomethacin 4.7217000239
MESH:D055728 Primary Myelofibrosis decitabine 4.3217616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0319131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0317292933
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.0315682402 12376480
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0316536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0316039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0315067354
MESH:D011471 Prostatic Neoplasms vorinostat 2.0317218635
MESH:D011507 Proteinuria Gentamicins 13.3815033597
MESH:D011507 Proteinuria Indomethacin 13.3811849393
MESH:D011507 Proteinuria Tretinoin 13.3816636307
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011625 Pterygium Tretinoin 4.3716723453
MESH:D011693 Purpura Raloxifene 5.1315770314
MESH:D051437 Renal Insufficiency Cisplatin 9.3015464296
MESH:D051437 Renal Insufficiency Gentamicins 9.3017132701 15728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.1719058328
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.1018172121 18155124
MESH:D012173 Retinitis Gentamicins 5.8518644591
MESH:D012175 Retinoblastoma Methylnitrosourea 5.0711555667
MESH:D012208 Rhabdomyosarcoma decitabine 9.6619155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.6616116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.0316646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.0314601052
MESH:D012640 Seizures 2,4-dinitrotoluene 4.9218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 4.9218551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.7119755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 15.7112065085
MESH:D012878 Skin Neoplasms sodium arsenite 15.7119524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.718532709
MESH:D012878 Skin Neoplasms Tretinoin 15.7116467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9215464296
MESH:D013088 Spermatocele Tamoxifen 3.8716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4712854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8412587719
MESH:D013272 Stomach Diseases Indomethacin 4.0017160473 16280098 10486359 17638125 10215738 10192188 18209964 18545984 17207306 16184426 15038085 16113693 15472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 11.7017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 11.702093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 11.7015958060 18396642 17522103
MESH:D013274 Stomach Neoplasms decitabine 11.7019037991
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 11.7016033868
MESH:D013274 Stomach Neoplasms Indomethacin 11.7015609394
MESH:D013274 Stomach Neoplasms Methylnitrosourea 11.7016257854 15930296 18593901
MESH:D013274 Stomach Neoplasms Tretinoin 11.7017261132
MESH:D013276 Stomach Ulcer Indomethacin 3.2210750652 16755016 11523592 10878458 17657623 17977527 11595415 17627676 16252198 18431645 15255614 11906479 11729361 15104355 17654042 17895592 16150113 15138204 14567935 12077510 16169175 16397915 11145282 10423059 18193104 16631530 12498302 18209962 12500499 17918041 12467913 18181030 18543354 18726076 18237397 16934674 18087811 11595431 12787963 1323529 17135157 18299717
MESH:D020521 Stroke Raloxifene 3.4916837676
MESH:D013733 Testicular Diseases Acrylamide 9.6115864552
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 9.6115864552
MESH:D013736 Testicular Neoplasms Cisplatin 4.2417225452 15464296
MESH:D013921 Thrombocytopenia vorinostat 4.6120479100
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.8111418001
MESH:D013964 Thyroid Neoplasms arsenic trioxide 19.1219014326
MESH:D013964 Thyroid Neoplasms decitabine 19.1217967635
MESH:D013964 Thyroid Neoplasms Indomethacin 19.1218791128 11352223 14736730
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 19.127505956 3078959
MESH:D013964 Thyroid Neoplasms Tretinoin 19.1217045167 16026305
MESH:D013978 Tibial Fractures Raloxifene 4.7819048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4316051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5415213294
MESH:D014376 Tuberculosis Tretinoin 2.9616040207
MESH:D014456 Ulcer Indomethacin 4.4717380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 29.5416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 29.5416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 29.5412845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 29.5417053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 29.5412973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms decitabine 29.5419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 29.5417572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 29.5417306315 16452187 16712894 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 29.548653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.5910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.5910091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 13.8116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.8111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.8116129372
MESH:D014604 Uveal Neoplasms decitabine 11.4017785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.4016752155
MESH:D014605 Uveitis Cyclosporine 3.561336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2015577323
MESH:D014652 Vascular Diseases sodium arsenite 4.0117056641
MESH:D054556 Venous Thromboembolism Raloxifene 4.7816837676
MESH:D015837 Vestibular Diseases Gentamicins 5.1218776599
MESH:D014820 Vitiligo Tretinoin 3.6616761959
MESH:D014839 Vomiting Cisplatin 10.1111897121
MESH:D014839 Vomiting Indomethacin 10.1111897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1316343187
MESH:D009396 Wilms Tumor Tretinoin 3.6116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0117120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04210 Apoptosis
KEGG:04510 Focal adhesion
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26060
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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