AutismKB 2.0

Annotation Detail for KDM5D


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Basic Information Top
Gene Symbol:KDM5D ( HY,HYA,JARID1D,KIAA0234,SMCY )
Gene Full Name: lysine (K)-specific demethylase 5D
Band: Yq11.223
Quick LinksEntrez ID:8284; OMIM: 426000; Uniprot ID:KDM5D_HUMAN; ENSEMBL ID: ENSG00000012817; HGNC ID: 11115
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
increased development of adult T-cell leukemia/lymphoma
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of KDM5D mRNAaffects expression 20127859
D012643 Selenium Selenium results in increased expression of KDM5D mRNAincreases expression 18583539
C024746 tobacco tar tobacco tar results in decreased expression of KDM5D mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.886695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.2319559774
MESH:D003092 Colitis Selenium 4.4317936198
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2615131321
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D006333 Heart Failure Selenium 3.3217162251
MESH:D007251 Influenza, Human Selenium 5.0616624496
MESH:D007676 Kidney Failure, Chronic Selenium 4.3716518626
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1720195826 21137059
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720064080 18569708 6695378 20464547 20135361 18816296 20869020 18520028 17053015
MESH:D008325 Mammary Neoplasms, Experimental Selenium 3.0215318939
MESH:D008654 Mesothelioma Selenium 2.9315107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3511141357
MESH:D010954 Plasmacytoma Selenium 5.7615087411
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3117053015
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35965
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00126 - Vitamin C Antioxidants;Essential Vitamins;Free Radical Scavengers;Vitamins (Vitamin C);Vitamins
    No data
    No data
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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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