Annotation Detail for TRRAP
Basic Information
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| Gene Symbol: | TRRAP ( FLJ10671,PAF350/400,PAF400,STAF40,TR-AP,Tra1 ) |
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| Gene Full Name: | transformation/transcription domain-associated protein |
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| Band: | 7q22.1 |
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| Quick Links | Entrez ID:8295; OMIM: 603015; Uniprot ID:TRRAP_HUMAN; ENSEMBL ID: ENSG00000196367; HGNC ID: 12347 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| 200027 | E2F transcription factor network |
| 200106 | Regulation of Wnt-mediated beta catenin signaling and target gene transcription |
| 200093 | C-MYC pathway |
| 200045 | Validated targets of C-MYC transcriptional activation |
| 200101 | Direct p53 effectors |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of TRRAP mRNA | decreases expression | 20106945
|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of TRRAP mRNA | decreases expression | 20504355
|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRRAP mRNA | decreases expression | 20018196
19150397
|
| D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in decreased expression of TRRAP mRNA | decreases expression | 15336504
|
| C017557 |
nickel subsulfide |
nickel subsulfide results in decreased expression of TRRAP mRNA | decreases expression | 12760830
|
| C006253 |
pirinixic acid |
pirinixic acid results in decreased expression of TRRAP mRNA | decreases expression | 16940010
|
| D012643 |
Selenium |
Selenium results in increased expression of TRRAP mRNA | increases expression | 19244175
|
| C016104 |
sodium bichromate |
sodium bichromate results in decreased expression of TRRAP mRNA | decreases expression | 12760830
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.42 | 18653653 |
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.04 | 20464547 20127859 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.80 | 6695378 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.88 | 16434500 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.43 | 19183758 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.43 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
2.00 | 17474063 20146248 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.11 | 20419170 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.90 | 20889678 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.03 | 19176532 |
| MESH:D003092 |
Colitis |
|
Selenium |
4.14 | 17936198 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.53 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Selenium |
2.23 | 15131321 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.76 | 12083418 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
4.54 | 20426865 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
4.54 | 16530937 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.04 | 19236843 20131406 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.78 | 20471113 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
7.48 | 20558911 |
| MESH:D006333 |
Heart Failure |
|
Selenium |
7.48 | 17162251 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.35 | 19772884 16221962 19176532 18467677 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.45 | 20558911 |
| MESH:D007251 |
Influenza, Human |
|
Selenium |
4.64 | 16624496 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.80 | 16306350 |
| MESH:D007676 |
Kidney Failure, Chronic |
|
Selenium |
4.17 | 16518626 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
4.66 | 21137059 20195826 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.66 | 15890375 20007298 16377806 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
1.57 | 6695378 20464547 18569708 18520028 20064080 20869020 17053015 18816296 20135361 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Selenium |
2.92 | 15318939 |
| MESH:D008545 |
Melanoma |
marker/mechanism |
|
| 21499247 |
| MESH:D008654 |
Mesothelioma |
|
Selenium |
2.88 | 15107826 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.40 | 16381670 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.86 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.24 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.16 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
5.22 | 11141357 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
5.22 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.86 | 20558911 |
| MESH:D010954 |
Plasmacytoma |
|
Selenium |
5.33 | 15087411 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.93 | 17292933 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.50 | 19058328 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
6.09 | 10029692 19755658 |
| MESH:D012878 |
Skin Neoplasms |
|
tert-Butylhydroperoxide |
6.09 | 8532709 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 20155912 2093021 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
2.26 | 17053015 |
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