AutismKB 2.0

Annotation Detail for SNN


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Basic Information Top
Gene Symbol:SNN ( - )
Gene Full Name: stannin
Band: 16p13.13
Quick LinksEntrez ID:8303; OMIM: 603032; Uniprot ID:SNN_HUMAN; ENSEMBL ID: ENSG00000184602; HGNC ID: 11149
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
QT interval
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SNN mRNAdecreases expression 18648102
D019386 Alendronate Alendronate affects the expression of SNN mRNAaffects expression 16079270
C103303 alitretinoin alitretinoin results in decreased expression of SNN mRNAdecreases expression 16648578
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SNN mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in decreased expression of SNN mRNAdecreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of SNN mRNAdecreases expression 12075121
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of SNN mRNAdecreases expression 17553608
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SNN mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of SNN mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SNN mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SNN mRNAdecreases expression 17557909
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of SNN mRNAincreases expression 15954086
D005996 Nitroglycerin Nitroglycerin results in decreased expression of SNN mRNAdecreases expression 12102619
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SNN mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene affects the expression of SNN mRNAaffects expression 16079270
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA]decreases reaction|increases expression 19225232
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Ethylnitrosourea 7.046695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5316434500
MESH:D000419 Albuminuria Raloxifene 4.6317451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1719483382
MESH:D001862 Bone Resorption bisphenol A 3.8911985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9114991843
MESH:D001930 Brain Injuries Raloxifene 4.5216580743
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.3216357521 15144691 18412241 16436596 16651633
MESH:D001943 Breast Neoplasms alitretinoin 2.0716344269
MESH:D001943 Breast Neoplasms bexarotene 2.0716344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 2.0717123778
MESH:D001943 Breast Neoplasms Raloxifene 2.0717893378 17242785 15758505 16837676 15775269 17049068 15572757 17595753 17440819 17952589 16912660 17261762
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.757296757 3581430
MESH:D002278 Carcinoma in Situ bisphenol A 5.0417123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2316247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1017572228
MESH:D006332 Cardiomegaly valsartan 4.2019597038
MESH:D009202 Cardiomyopathies valsartan 4.4516247790
MESH:D002318 Cardiovascular Diseases Raloxifene 7.9315775269
MESH:D002318 Cardiovascular Diseases valsartan 7.9311230374
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.387505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3812371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 11.3816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.0517160924
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.3919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 19.3919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.3915861022 17681005 16919318 11677210 17333356 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 19.3919176532
MESH:D003072 Cognition Disorders Raloxifene 4.6615800139
MESH:D003324 Coronary Artery Disease valsartan 3.9017719468
MESH:D003384 Coxsackievirus Infections valsartan 5.8920392896
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1917474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8411906362 11298694 12868966 8970840 2524372 14531868 18759878 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.523621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.6211508273
MESH:D003928 Diabetic Nephropathies Raloxifene 9.6017308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies valsartan 9.6011427623 18630688
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.9716192314 9328219 7440962 6482804 18289764 11289319 6679447 18648102 18692083 8291058 1440618 9022650 9653073
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.0518357618
MESH:D004487 Edema pirinixic acid 6.9912083418
MESH:D004487 Edema Raloxifene 6.9915860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.2415845917
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.113581430
MESH:D005234 Fatty Liver Cyclosporine 19.0119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.0115345470
MESH:D005234 Fatty Liver pirinixic acid 19.0119236843 20131406
MESH:D005234 Fatty Liver Raloxifene 19.0117473493
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005355 Fibrosis Cyclosporine 9.2912168785 12639820
MESH:D005355 Fibrosis valsartan 9.2916893502
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Ethylnitrosourea 3.8516436596
MESH:D005910 Glioma Ethylnitrosourea 3.5016357521 16651633 18412241
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.5816928621
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006261 Headache Nitroglycerin 5.2511554966 11284996
MESH:D006331 Heart Diseases Raloxifene 3.5511110106
MESH:D006333 Heart Failure pirinixic acid 7.4420558911
MESH:D006333 Heart Failure valsartan 7.4419027736
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0419176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Alendronate 4.7416769263
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Cyclosporine 8.8810903974
MESH:D006973 Hypertension Raloxifene 8.8815787275 17577099
MESH:D006973 Hypertension valsartan 8.8820102058 10903974 12850387 16475468 18344623 11427623 18390891 12692753
MESH:D006974 Hypertension, Malignant valsartan 6.4711560862
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007333 Insulin Resistance bisphenol A 7.3716393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.6916144296
MESH:D007674 Kidney Diseases Cyclosporine 6.4918776723 8314463 10903974
MESH:D007674 Kidney Diseases valsartan 6.4916893502 12164870 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.636582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6312371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 12.6317379185
MESH:D007889 Leiomyoma Raloxifene 4.5316973256
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.8115474484
MESH:D008106 Liver Cirrhosis, Experimental valsartan 2.8115504291 16872305 15619341
MESH:D008113 Liver Neoplasms pirinixic acid 1.8315890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.551399818 3712494 598648 6587162
MESH:D008175 Lung Neoplasms alitretinoin 3.8016413115
MESH:D008175 Lung Neoplasms bexarotene 3.8017849452
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.8016019985 6695378 16271038 17703301
MESH:D008223 Lymphoma Ethylnitrosourea 3.9615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.0915375218
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.1911161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.6719196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.6710838139 10767621 18041768
MESH:D008579 Meningioma Ethylnitrosourea 6.0517943659
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.763537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.1614659530
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction Nitroglycerin 6.0514729435
MESH:D009203 Myocardial Infarction pirinixic acid 6.0519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009232 Myxoma Raloxifene 5.6216343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.483581430
MESH:D009369 Neoplasms alitretinoin 5.2616946489
MESH:D009369 Neoplasms pirinixic acid 5.2617405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.4416707424
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8519196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 4.0111399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.936679447
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.4717160924 16003739 16651423
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.454026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.0517160924
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010024 Osteoporosis Alendronate 7.8517882678
MESH:D010024 Osteoporosis Raloxifene 7.8519059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2615758505 17893378 15579764 17823083
MESH:D010049 Ovarian Diseases bisphenol A 5.0411985600
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D017499 Porokeratosis alitretinoin 6.0716144296
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.0010548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2420887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.4516740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.4516536755 16220300 15731164
MESH:D011507 Proteinuria valsartan 4.8918344623 17664856 12164870
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8410548101
MESH:D011658 Pulmonary Fibrosis valsartan 3.8217241526
MESH:D011693 Purpura Raloxifene 5.6215770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.708532709
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D020521 Stroke Raloxifene 3.8416837676
MESH:D019966 Substance-Related Disorders bisphenol A 4.0316045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.2115790496
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.903712494 1399818 6582329 7505956 6587162
MESH:D013978 Tibial Fractures Raloxifene 5.2719048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.238074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.2317572228
MESH:D014591 Uterine Diseases bisphenol A 5.0714652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.2716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D020257 Ventricular Remodeling valsartan 5.7519027736
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6216343187
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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