AutismKB 2.0

Annotation Detail for ACOX3


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Basic Information Top
Gene Symbol:ACOX3 ( - )
Gene Full Name: acyl-CoA oxidase 3, pristanoyl
Band: 4p16.1
Quick LinksEntrez ID:8310; OMIM: 603402; Uniprot ID:ACOX3_HUMAN; ENSEMBL ID: ENSG00000087008; HGNC ID: 121
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
hsa00592alpha-Linolenic acid metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
hsa01040Biosynthesis of unsaturated fatty acids
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500820Beta-oxidation of pristanoyl-CoA
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ACOX3 mRNAincreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACOX3 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ACOX3 mRNAaffects expression 12734012
C071192 entacapone entacapone binds to ACOX3 proteinaffects binding 19783845
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACOX3 mRNAincreases expression 16267337
C066340 tolcapone tolcapone binds to ACOX3 proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.8111080934
MESH:D000544 Alzheimer Disease entacapone 5.4120150427
MESH:D000544 Alzheimer Disease tolcapone 5.4120150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016097048 15673190 18705752 15721981 10355542 15700767 16011737 16050911 16124888 16227642 3786805 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 8697196 12621046 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003866 Depressive Disorder entacapone 9.517768276
MESH:D003866 Depressive Disorder tolcapone 9.5111224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 5.1910440460
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.776884620 6623471 21278145 10092053 7179309 7120509 2869522 3786805 10915739 15998439 16227642 15027814 16177239 3732212 7440962 15968718 4309450 19336974 17522070 19085960 9327722 11566570
MESH:D056486 Drug-Induced Liver Injury entacapone 9.7719783845
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.7720420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 9.7719783845 16604736
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.9211455177
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D054908 Extensively Drug-Resistant Tuberculosis entacapone 16.5119578428
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 16.5119578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4912795759 17595544 16045604 61145 15959796 19224547 12631006 16239168
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.0220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16959395 15340226 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9621278145 11903743 11408273 16943688 17174718 16221502 17334410 16239168 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3612898905 15931870 18279442 17869086 12445421 16136751 18339082 18054572 12632512 18376398 15673190 16015684 20821823 18251166 18429990 17922224 16027843 17714472 13678700 12445418 11481614 18472094 15876570 14512876 12667390 15370692 15730626 12389079 15996030 17698563 17557913 15925388 12741479 17708605 15362042 16638106 18210741 18006644 18412020 14620537 18205269 12649538 16192424 17761835 16248980 15818738 17721639 17481882 12586293 17900296 18418968 15057751 17525996 17976157 18187930 14724832 17766677 18481824 12632514 18263696 17640975 15959796 10355542 15052691 17805973 12609069 18156304 17823541 15893842 18166357 15650968 18317297 12958196 14748882 17631135 16116963 15123356 18395095 15338365 17565644 12546737 17944888 18395914 14716833 18420326 18277467 18472332 16033810 16011737 18705752 14716496 12666154 16097048
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1415830285 16964402 17285989 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7319294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3712151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D010300 Parkinson Disease entacapone 6.6820334432 19783845 19578428 17089403 11586115
MESH:D010300 Parkinson Disease tolcapone 6.681977408 9591521 19578428 20216409 8635184 9305320 9708959 11432539 11746615 10651109 9754991 16758261 17089403 9333106 18328768 20334432 19783845 8739811 7566641 11586115 11793426
MESH:D020734 Parkinsonian Disorders entacapone 5.7018722529
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11222880 11399792 11896295
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D018088 Tuberculosis, Multidrug-Resistant entacapone 16.5119578428
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 16.5119578428
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D014820 Vitiligo tolcapone 5.5710573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:00592 alpha-Linolenic acid metabolism
KEGG:01040 Biosynthesis of unsaturated fatty acids
KEGG:00071 Fatty acid metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04146 Peroxisome
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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