AutismKB 2.0

Annotation Detail for AXIN1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:AXIN1 ( AXIN,MGC52315 )
Gene Full Name: axin 1
Band: 16p13.3
Quick LinksEntrez ID:8312; OMIM: 603816; Uniprot ID:AXN1_HUMAN; ENSEMBL ID: ENSG00000103126; HGNC ID: 903
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04310Wnt signaling pathway
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by Wnt
Pathway IDPathway Name
200064Canonical Wnt signaling pathway
200093C-MYC pathway
200180N-cadherin signaling events
200195TGF-beta receptor signaling
200052Presenilin action in Notch and Wnt signaling
Pathway IDPathway Name
P00005Angiogenesis
P00057Wnt signaling pathway
Pathway IDPathway Name
500310Degradation of beta-catenin by the destruction complex
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00048Hepatocellular carcinoma
No data
No data
No data
Desease Name
Hepatocellular carcinoma, somatic
Caudal duplication anomaly
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of AXIN1 mRNAincreases expression 20826375
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AXIN1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AXIN1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AXIN1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AXIN1 mRNAdecreases expression 19150397
D001622 Betaine [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 geneaffects cotreatment|increases methylation 16868943
C006780 bisphenol A bisphenol A results in increased expression of AXIN1 mRNAincreases expression 20826375
D002118 Calcium Calcium affects the expression of AXIN1 mRNAaffects expression 15913539
D002794 Choline [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 geneaffects cotreatment|increases methylation 16868943
D004958 Estradiol Estradiol results in increased expression of AXIN1 mRNAincreases expression 20826375
D005492 Folic Acid [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 geneaffects cotreatment|increases methylation 16868943
D011374 Progesterone Progesterone affects the expression of AXIN1 mRNAaffects expression 17251523
D011374 Progesterone Progesterone results in increased expression of AXIN1 mRNAincreases expression 17170212
D018038 Sodium Selenite Sodium Selenite results in increased expression of AXIN1 mRNAincreases expression 18175754
D014805 Vitamin B 12 [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 geneaffects cotreatment|increases methylation 16868943
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D058186 Acute Kidney Injury Folic Acid 4.3817003819 16316344 16595132
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D000236 Adenoma Folic Acid 3.8216963246
MESH:D000544 Alzheimer Disease Folic Acid 5.2717116317
MESH:D000544 Alzheimer Disease Vitamin B 12 5.2717116317
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001321 Autistic Disorder Acetaminophen 2.8918445737
MESH:D001321 Autistic Disorder Choline 2.8916818868
MESH:D001321 Autistic Disorder Folic Acid 2.8921388746
MESH:D001321 Autistic Disorder Vitamin B 12 2.8916297937
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 4.3315380490 15665606 15845082
MESH:D001943 Breast Neoplasms bisphenol A 2.0317123778
MESH:D001943 Breast Neoplasms Estradiol 2.0316675129 19861407 14630087 17289903 17018787 17261762 18497071 12948864
MESH:D001943 Breast Neoplasms Folic Acid 2.0316777985
MESH:D001943 Breast Neoplasms Progesterone 2.0316175315 15562024 17614352
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.553084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5516924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002318 Cardiovascular Diseases Folic Acid 3.9916755160
MESH:D002386 Cataract Acetaminophen 2.6110977129
OMIM:607864 CAUDAL DUPLICATION ANOMALY marker/mechanism
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7718566989
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002971 Cleft Lip Folic Acid 4.0021254359
MESH:D002972 Cleft Palate Folic Acid 3.5921254359 8946559
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7017116713 17087956 16985020 16963246 17245555
MESH:D023903 Coronary Restenosis Vitamin B 12 6.3216489563
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0918551238
MESH:D002658 Developmental Disabilities Choline 4.7116818868
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.1416886840
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3017522070 11739529 11421492 19370779 11287661 11743745 19739265 11461765 10915739 12705907 16081117 16485898 15968718 10663392 16109766 12540782 17906064 11529661 15619225 18071297 12958197 14725611 16177239 19416960 11834606 18713872 19420014 16781746 2444490 12392966 19164858 14550746 14986274 12153990 19923254 16393943 10774834 17562736 19085960 12594235 16227642
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.3015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8417692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.8611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Folic Acid 7.8617301261
MESH:D004715 Endometriosis Progesterone 3.8216134523
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D017889 Exfoliation Syndrome Folic Acid 5.5716504073
MESH:D005756 Gastritis Acetaminophen 11.6016983495
MESH:D005756 Gastritis Folic Acid 11.6017171786
MESH:D005901 Glaucoma Folic Acid 5.1416504073
MESH:D006330 Heart Defects, Congenital Folic Acid 7.9516524890 17286298
MESH:D006330 Heart Defects, Congenital Vitamin B 12 7.9517124548
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D006679 HIV Seropositivity Folic Acid 5.5717209195
MESH:D006712 Homocystinuria Betaine 7.0417413090
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D020138 Hyperhomocysteinemia Folic Acid 10.3716865747 16755160 16433478 16397167 16395265
MESH:D020138 Hyperhomocysteinemia Vitamin B 12 10.3716397167
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007249 Inflammation Progesterone 2.6215869954
MESH:D007333 Insulin Resistance bisphenol A 12.6116393666
MESH:D007333 Insulin Resistance Estradiol 12.6116393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 12.6114714311
MESH:D007674 Kidney Diseases Acetaminophen 5.9812587719 15629191
MESH:D007674 Kidney Diseases Estradiol 5.9815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5116705839
MESH:D007680 Kidney Neoplasms Estradiol 7.5115610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.1416316344
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.2614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Vitamin B 12 3.2618239293
MESH:D008107 Liver Diseases Acetaminophen 4.2919784758 11587558 12969438 12587719 16611625 19460945 19014921 16610002
MESH:D008107 Liver Diseases Folic Acid 4.2916877991
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms Betaine 4.6619642983
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 6.3317718048
MESH:D008180 Lupus Erythematosus, Systemic Vitamin B 12 6.3317718048
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1711408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.1711408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.7816832597
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D009203 Myocardial Infarction Vitamin B 12 4.7517412321
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9418551238
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations bisphenol A 9.9611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 9.9611399458 16427766
MESH:D009436 Neural Tube Defects Betaine 8.5917413090
MESH:D009436 Neural Tube Defects Folic Acid 8.5917438019
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009503 Neutropenia Folic Acid 4.5616322990
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4816049721 12819281
MESH:D010024 Osteoporosis Calcium 3.8117882678
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9219401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9217393432 16525653
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.0310548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.7420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.7420887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5916740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5918760546
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D051437 Renal Insufficiency Folic Acid 4.8515728788
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012559 Schizophrenia Folic Acid 2.9016641680
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5718551238
MESH:D012871 Skin Diseases Folic Acid 3.2618709164
MESH:D013118 Spinal Cord Diseases Folic Acid 14.0416361298
MESH:D013118 Spinal Cord Diseases Vitamin B 12 14.0416361298
MESH:D013119 Spinal Cord Injuries Progesterone 4.3616503802 15862959
MESH:D013274 Stomach Neoplasms Folic Acid 2.7017171786
MESH:D020521 Stroke Folic Acid 9.7916517955
MESH:D020521 Stroke Vitamin B 12 9.7916517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716684133 16045194
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3016049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
KEGG:05200 Pathways in cancer
REACT:11045 Signaling by Wnt
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25195
    • No data
    Releated disease ID Related disease Name
    PA152240221Caudal Duplication Anomaly
    PA443560Breast Neoplasms
    PA445084Wilms Tumor
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04447 - 1,4-Dithiothreitol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved