AutismKB 2.0

Annotation Detail for BAP1


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Basic Information Top
Gene Symbol:BAP1 ( DKFZp686N04275,FLJ35406,FLJ37180,HUCEP-13,KIAA0272,UCHL2 )
Gene Full Name: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Band: 3p21.1
Quick LinksEntrez ID:8314; OMIM: 603089; Uniprot ID:BAP1_HUMAN; ENSEMBL ID: ENSG00000163930; HGNC ID: 950
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BAP1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of BAP1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide affects the expression of BAP1 mRNAaffects expression 17530438
C015329 lycopene lycopene results in increased expression of BAP1 mRNAincreases expression 16886892
C059514 resveratrol resveratrol results in decreased expression of BAP1 mRNAdecreases expression 12569576
D012643 Selenium Selenium results in increased expression of BAP1 mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of BAP1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.1316538975
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000236 Adenoma resveratrol 3.4615688382
MESH:D000544 Alzheimer Disease resveratrol 2.6216183991 16162502
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001169 Arthritis, Experimental resveratrol 3.6617115116
MESH:D050197 Atherosclerosis resveratrol 3.4216873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9516206674
MESH:D002545 Brain Ischemia resveratrol 4.6817600658
MESH:D001943 Breast Neoplasms resveratrol 2.6717534123 17651959 16393696
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.883084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8814691202 16217749 15073043 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.8816227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9916675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7816227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.6515458977
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D003092 Colitis resveratrol 10.8816474422
MESH:D003092 Colitis Selenium 10.8817936198
MESH:D003110 Colonic Neoplasms resveratrol 2.4916338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6820501625
MESH:D015179 Colorectal Neoplasms resveratrol 2.6816550006
MESH:D003327 Coronary Disease resveratrol 3.9216507316
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7810525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7819769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 4.0016873680
MESH:D003928 Diabetic Nephropathies resveratrol 4.2116286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6012958197 12540782 14725611 19416960 17522070 11739529 16109766 17906064 12705907 18071297 19370779 19739265 10774834 11743745 16781746 11461765 11421492 11529661 16081117 14550746 16177239 10915739 16485898 11287661 14986274 19923254 19085960 2444490 17562736 15619225 11834606 12153990 15968718 12594235 12392966 18713872 16393943 19164858 16227642 19420014 10663392
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema resveratrol 3.648985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.3517872969
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.2117923197
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 3.5715073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816863852 16490937
MESH:D006561 Herpes Simplex resveratrol 4.5716876885
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia resveratrol 4.2917188708
MESH:D006949 Hyperlipidemias resveratrol 4.3316873680
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5717488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 5.0117600658
MESH:D007249 Inflammation resveratrol 2.9716366677
MESH:D007251 Influenza, Human resveratrol 21.4116624496
MESH:D007251 Influenza, Human Selenium 21.4116624496
MESH:D007251 Influenza, Human Vitamin E 21.4116624496
MESH:D007674 Kidney Diseases Acetaminophen 6.4515629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.4512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2116705839
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1719850784 16467208 17050201 20471514 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.3617649720 15622746 19225113 12018890 16823087 17869043 11161223 17217047 15213294 12712474 12679006 17107899 16966277 19035177 16891316 16331271 17712046 16112521 15748426 15336539 19075265 11468182 16330433 19642359 9834237
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 8.3616087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 12587719 12969438 16611625 19014921 11587558 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 5.1014682389
MESH:D008113 Liver Neoplasms resveratrol 5.1019073162 20405173 19812893 19321006
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8920377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6011798837 19825857
MESH:D008175 Lung Neoplasms Vitamin E 2.6011062179
MESH:D016393 Lymphoma, B-Cell resveratrol 4.6017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.1014749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.6415688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.788985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.7815318939
MESH:D008545 Melanoma resveratrol 2.4017992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D008659 Metabolic Diseases resveratrol 4.6617112576
MESH:D009101 Multiple Myeloma arsenic trioxide 8.0714977855 19417148 19549372 15949261 11468182
MESH:D009101 Multiple Myeloma resveratrol 8.0717935668 14749477 16490592 17164350 17049120 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2717962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816882451 16105982
MESH:D009203 Myocardial Infarction resveratrol 3.1216317513 17015251 16456233 16525036 17125593 17188708
MESH:D017202 Myocardial Ischemia resveratrol 4.2317015251 17125593
MESH:D009205 Myocarditis resveratrol 5.1617322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms lycopene 3.8417051425
MESH:D009374 Neoplasms, Experimental resveratrol 4.368985016
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.1418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 9.1417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.7017929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6916049721 12819281
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5617513867
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4716624393 12452020 19769630
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.5716679765
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1319131511
MESH:D011471 Prostatic Neoplasms lycopene 2.1317337101 15084515
MESH:D011471 Prostatic Neoplasms resveratrol 2.1317675339 16731767 15767336 17718901 17804756 17636462
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1315084515
MESH:D051436 Renal Insufficiency, Chronic resveratrol 6.0316325855
MESH:D015427 Reperfusion Injury resveratrol 3.3917520802 16317513 16314181 15827377 17058453
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms resveratrol 3.1415837718 8985016
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.7416517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7516321402
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D014062 Tongue Neoplasms resveratrol 4.4816227395
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3912973940 11780464 12845720 20435036
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.3717473185
MESH:D014594 Uterine Neoplasms resveratrol 4.4617044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6617488730
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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