AutismKB 2.0

Annotation Detail for FZD1


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Basic Information Top
Gene Symbol:FZD1 ( DKFZp564G072,FLJ95923 )
Gene Full Name: frizzled homolog 1 (Drosophila)
Band: 7q21.13
Quick LinksEntrez ID:8321; OMIM: 603408; Uniprot ID:FZD1_HUMAN; ENSEMBL ID: ENSG00000157240; HGNC ID: 4038
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200052Presenilin action in Notch and Wnt signaling
200055Wnt signaling network
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FZD1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FZD1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of FZD1 mRNAdecreases expression 20458559
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of FZD1 mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of FZD1 mRNAdecreases expression 15894712
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of FZD1 mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FZD1 mRNAdecreases expression 15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FZD1 mRNAincreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of FZD1 mRNAdecreases expression 12075121
D004390 Chlorpyrifos Chlorpyrifos affects the expression of FZD1 mRNAaffects expression 18502319
D003474 Curcumin Curcumin results in decreased expression of FZD1 mRNAdecreases expression 15713895
D003976 Diazinon Diazinon affects the expression of FZD1 mRNAaffects expression 19130878
D004026 Dieldrin Dieldrin results in increased expression of FZD1 mRNAincreases expression 19130878
D004041 Dietary Fats Dietary Fats results in increased expression of FZD1 mRNAincreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of FZD1 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FZD1 mRNAdecreases expression 17351261
12075121
D019833 Genistein Genistein results in decreased expression of FZD1 mRNAdecreases expression 12075121
D017313 Fenretinide Fenretinide results in decreased expression of FZD1 mRNAdecreases expression 16467112
C058346 N-(4-methoxyphenyl)retinamide N-(4-methoxyphenyl)retinamide results in decreased expression of FZD1 mRNAdecreases expression 16467112
D009532 Nickel Nickel affects the expression of FZD1 mRNAaffects expression 19130878
D009534 Niclosamide Niclosamide affects the localization of FZD1 proteinaffects localization 19772353
C041786 palm oil palm oil results in increased expression of FZD1 mRNAincreases expression 18042831
D012402 Rotenone Rotenone results in decreased expression of FZD1 mRNAdecreases expression 19013527
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FZD1 mRNAincreases expression 15667827
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D055371 Acute Lung Injury Nickel 4.4616166738
MESH:D000230 Adenocarcinoma arsenic trioxide 13.2119825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.2120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.2114692618
MESH:D000230 Adenocarcinoma Fenretinide 13.2110697514
MESH:D000230 Adenocarcinoma Genistein 13.2111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.586695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2516835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.7416611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.7416487989
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9517887948
MESH:D000544 Alzheimer Disease Curcumin 2.5915590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.4715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5815885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7116807698
MESH:D050197 Atherosclerosis Curcumin 3.2418704882
MESH:D001327 Autoimmune Diseases Curcumin 4.3619761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.5616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001862 Bone Resorption bisphenol A 3.7411985600
MESH:D002545 Brain Ischemia Curcumin 4.2016770732
MESH:D001932 Brain Neoplasms Curcumin 8.7817596214
MESH:D001932 Brain Neoplasms Fenretinide 8.7816187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.9020146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 6.9017123778
MESH:D001943 Breast Neoplasms Calcitriol 6.9011237771
MESH:D001943 Breast Neoplasms Curcumin 6.9016243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Dieldrin 6.9015770527 11859874
MESH:D001943 Breast Neoplasms Dietary Fats 6.9020435547
MESH:D001943 Breast Neoplasms Fenretinide 6.9016601279
MESH:D001943 Breast Neoplasms Genistein 6.9016873071 16541309 17200150
MESH:D001943 Breast Neoplasms Nickel 6.9015986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.9020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2011589617
MESH:D002277 Carcinoma Curcumin 7.9418593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.4716705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.4715553829 14691202 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 6.4717159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.4716924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8617123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9318414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.5520419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.5511237771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.5518462866
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 10.5516274795
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.2116332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.356135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.3520889678
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.3416154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7817110522 17681005 17333356 16105132 15861022 11677210 16919318
MESH:D016770 Ciliophora Infections Niclosamide 5.6012113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.058697196 15668235 15340226 12621046 16354765
MESH:D003092 Colitis Curcumin 4.0518200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 4.4318809619
MESH:D003110 Colonic Neoplasms arsenite 5.8115037631
MESH:D003110 Colonic Neoplasms Curcumin 5.8119359593 16340194
MESH:D003110 Colonic Neoplasms Genistein 5.8117182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7720501625
MESH:D015179 Colorectal Neoplasms Fenretinide 2.7717273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.7718497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4310048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9715213294
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.8217244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.512952479
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.9818403477
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9817107852
MESH:D003928 Diabetic Nephropathies Curcumin 3.9018204486
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9217351913
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004417 Dyspnea Diazinon 4.6716487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.6715138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6712538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.4616402032
MESH:D016889 Endometrial Neoplasms Genistein 3.2811473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.0112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver arsenic trioxide 23.3915073043
MESH:D005234 Fatty Liver arsenite 23.3918296743
MESH:D005234 Fatty Liver Curcumin 23.3919297423
MESH:D005234 Fatty Liver Dietary Fats 23.3919004024 18296743 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.3915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005355 Fibrosis arsenite 20.1318296743
MESH:D005355 Fibrosis Curcumin 20.1318705752
MESH:D005355 Fibrosis Dietary Fats 20.1318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.1320067830
MESH:D005393 Fish Diseases Niclosamide 5.5712113305
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1316904648
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5618462866
MESH:D005909 Glioblastoma Curcumin 11.5817596214
MESH:D005909 Glioblastoma Fenretinide 11.5816187019
MESH:D005909 Glioblastoma Genistein 11.5816598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.5718829502 18462866
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2211294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis Diazinon 4.4516487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7615340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9117701891
MESH:D015658 HIV Infections Nickel 3.7517263646
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9215340226 8697196 18606429 16959395 16354765
MESH:D006937 Hypercholesterolemia Curcumin 8.8318704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.4921332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6816569931 16945680
MESH:D007247 Infertility, Female Dieldrin 9.8810630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.8812013081
MESH:D007248 Infertility, Male Diazinon 6.6612948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6617937319
MESH:D007249 Inflammation Curcumin 11.4617151092 18403477 16956363
MESH:D007249 Inflammation Dietary Fats 11.4620412841
MESH:D007249 Inflammation Nickel 11.4616166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.4612200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1618200517 18596194
MESH:D007333 Insulin Resistance bisphenol A 7.2116393666
MESH:D007333 Insulin Resistance Dietary Fats 7.2111836018 18457598
MESH:D007414 Intestinal Neoplasms Curcumin 4.1010783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.8716705839
MESH:D007889 Leiomyoma Curcumin 4.4518555241
MESH:D007938 Leukemia arsenic trioxide 10.1915070760
MESH:D007938 Leukemia Curcumin 10.1918462866
MESH:D007938 Leukemia Genistein 10.1918980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.3617077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.3616106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1216467208 19850784 17050201 20471514 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1315213294 16330433 19075265 17217047 19035177 15336539 19642359 15748426 12712474 16331271 17712046 17869043 16112521 12018890 16891316 19225113 11468182 16966277 17107899 15622746 9834237 12679006 17649720 11161223 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.2916882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.2916106398
MESH:D007972 Leukoplakia, Oral Fenretinide 5.9216707609
MESH:D008103 Liver Cirrhosis arsenite 6.6218296743
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6218296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.4717355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.4717823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008107 Liver Diseases Chlorpyrifos 4.5115991261
MESH:D008107 Liver Diseases Curcumin 4.5116956363
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.737678174
MESH:D008113 Liver Neoplasms arsenic trioxide 13.7314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.7321137059 20195826
MESH:D008113 Liver Neoplasms Dieldrin 13.739539021 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.7316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.332876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.3320377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2515213294
MESH:D008175 Lung Neoplasms arsenic trioxide 6.4319825857 11798837
MESH:D008175 Lung Neoplasms arsenite 6.4316809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4318569708 20869020 18816296 17053015 20464547 20135361 6695378 20064080 18520028
MESH:D008175 Lung Neoplasms Curcumin 6.4319359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4311884234 19555203
MESH:D008223 Lymphoma Curcumin 3.4918462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5616173963
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 6.1810697514
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.1812929590 14578162
MESH:D008545 Melanoma Curcumin 3.7318462866 17885582
MESH:D008545 Melanoma Fenretinide 3.7316270382
MESH:D008569 Memory Disorders Curcumin 4.0317263510
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.4416381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.4416274795
MESH:D009101 Multiple Myeloma arsenic trioxide 7.1319417148 11468182 19549372 14977855 15949261
MESH:D009101 Multiple Myeloma Curcumin 7.1319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7917962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0716882451 16105982
MESH:D009203 Myocardial Infarction Genistein 2.8017141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.5617141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.737678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.9016624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.9018495463
MESH:D009369 Neoplasms Benzo(a)pyrene 8.1411141357
MESH:D009369 Neoplasms Dieldrin 8.148820588
MESH:D009369 Neoplasms Fenretinide 8.1417353921 15958647
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4012497104
MESH:D009389 Neovascularization, Pathologic arsenite 4.2815738583
MESH:D009410 Nerve Degeneration Rotenone 3.7818619942 17356569 15790535
MESH:D009421 Nervous System Malformations bisphenol A 15.6716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 15.6716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.6714600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.5018462866
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0310525206
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.5516303764
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.0815081274
MESH:D009765 Obesity Curcumin 4.6719297423
MESH:D009765 Obesity Dietary Fats 4.6719632207 11836018 17217161 18674790 21332399 18457598 20518802 16723640 20132043
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3216049721
MESH:D010024 Osteoporosis Curcumin 7.0918719352
MESH:D010024 Osteoporosis Genistein 7.0919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9616169203
MESH:D010049 Ovarian Diseases bisphenol A 4.8611985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.0319769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 11.0318462866 19020741
MESH:D010051 Ovarian Neoplasms Fenretinide 11.0316133793
MESH:D010051 Ovarian Neoplasms Genistein 11.0319005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.5315580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.5319401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms Fenretinide 8.5315580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0419927285
MESH:D010300 Parkinson Disease Dieldrin 5.6817291500 11445065 11181820 16112328 16809432
MESH:D010300 Parkinson Disease Rotenone 5.6818619942 15451049 16140633 11535288 16412576 19232380 18191903 11445065 19114014
MESH:D020734 Parkinsonian Disorders Rotenone 3.9615574749 18197244 15795934 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D011041 Poisoning Diazinon 4.2317603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.0710548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0711222880 11896295 11399792 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6515572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0816740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0812479363 16289102 15754350 18247401 16644109
MESH:D011471 Prostatic Neoplasms Curcumin 2.0815129424 12497104 11398177 18156803 18226269 10851300 18769126
MESH:D011471 Prostatic Neoplasms Fenretinide 2.0817024972
MESH:D011471 Prostatic Neoplasms Genistein 2.0815378649 15256057 16925846
MESH:D011537 Pruritus Ethinyl Estradiol 3.1815861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.6510548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.4119168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9010666014 18379247
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.5116611668 17119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.7616611668 17119214
MESH:D012162 Retinal Degeneration Fenretinide 4.3016303925
MESH:D012509 Sarcoma Curcumin 4.0018462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8316646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4518551238
MESH:D018805 Sepsis Curcumin 3.9718389075
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.966418539
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.1719755658 10029692
MESH:D012878 Skin Neoplasms Fenretinide 13.1716467112
MESH:D012878 Skin Neoplasms N-(4-methoxyphenyl)retinamide 13.1716467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.1716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8116709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3420155912 2093021
MESH:D013276 Stomach Ulcer Curcumin 3.3816631530 19188055
MESH:D019966 Substance-Related Disorders bisphenol A 3.8516045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.9919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8315213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.2816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.2820435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.2817053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.2818593936
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 15.2816720286
MESH:D014565 Urogenital Neoplasms Curcumin 5.1318462866
MESH:D014570 Urologic Diseases Diazinon 5.1516487989
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1910091137
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.4516154183
MESH:D014591 Uterine Diseases bisphenol A 4.8814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1714692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
KEGG:04310 Wnt signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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