AutismKB 2.0

Annotation Detail for HIST2H2AA3


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Basic Information Top
Gene Symbol:HIST2H2AA3 ( H2A,H2A.2,H2A/O,H2A/q,H2AFO,H2a-615,HIST2H2AA )
Gene Full Name: histone cluster 2, H2aa3
Band: 1q21.2
Quick LinksEntrez ID:8337; OMIM: 142720; Uniprot ID:H2A2A_HUMAN; ENSEMBL ID: ENSG00000183558; HGNC ID: 4736
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HIST2H2AA3 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HIST2H2AA3 mRNAincreases expression 20064835
C014347 decitabine decitabine results in increased expression of HIST2H2AA3 mRNAincreases expression 19194470
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of HIST2H2AA3 mRNAincreases expression 17572062
C008493 methylselenic acid methylselenic acid results in decreased expression of HIST2H2AA3 mRNAdecreases expression 18548127
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HIST2H2AA3 proteindecreases expression 16548065
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8420146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.8419208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9320419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9319215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 16120746 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 15340226 16354765 8697196 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.6419294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6919215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16959395 15340226 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007248 Infertility, Male decitabine 3.4017581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007938 Leukemia decitabine 3.2118980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.3319117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4219387464 17679729 18704418 19010910 18206229 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6620195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.4417365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2518816296 20064080 6695378 18520028 18569708 20869020 20464547 17053015 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2511884234 19555203
MESH:D008223 Lymphoma decitabine 3.6419470736
MESH:D008545 Melanoma decitabine 2.2816505122 17785578
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2818303189 16166281 16966607
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009101 Multiple Myeloma decitabine 3.5618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5419010910 16882708 19157545 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5611141357
MESH:D009369 Neoplasms decitabine 5.5619470736 19116145 17925555
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D010051 Ovarian Neoplasms decitabine 2.7219259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.8519294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 5.1517616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3417292933
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.3416205645
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1317365031 17322281 17975199 15814490
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.7519155313
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9016192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.522093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.5219037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms decitabine 3.5717967635
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4717053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4717616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.4317785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
REACT:22172 Chromosome Maintenance
REACT:27271 Meiotic Recombination
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29113
    • No data
    Releated disease ID Related disease Name
    PA445174Osteoarthritis
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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