AutismKB 2.0

Annotation Detail for TCF7L1


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Basic Information Top
Gene Symbol:TCF7L1 ( TCF-3,TCF3 )
Gene Full Name: transcription factor 7-like 1 (T-cell specific, HMG-box)
Band: 2p11.2
Quick LinksEntrez ID:83439; OMIM: 604652; Uniprot ID:TF7L1_HUMAN; ENSEMBL ID: ENSG00000152284; HGNC ID: 11640
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa04310Wnt signaling pathway
hsa05216Thyroid cancer
hsa04520Adherens junction
hsa05221Acute myeloid leukemia
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05217Basal cell carcinoma
hsa05215Prostate cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TCF7L1 mRNAdecreases expression 20382639
D002117 Calcitriol Calcitriol results in decreased expression of TCF7L1 mRNAdecreases expression 16002434
C079198 S 1 (combination) TCF7L1 protein results in decreased susceptibility to S 1 (combination)decreases response to substance 16734730
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of TCF7L1 mRNAdecreases expression 17951470
D014635 Valproic Acid Valproic Acid results in increased expression of TCF7L1 mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of TCF7L1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9918775368 18316065 18985861 17507914 19460635 17688650 18558336 20603192 18940202 17157402 19232924 16609825 18396377 15238991 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.2120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Calcitriol 2.5711237771
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 4.1518347146 18212800
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.6011237771
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 5.6015984520
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7917688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7919769572
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.241733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Valproic Acid 3.6214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5118558336 8888407
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 6.1419093184
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 4.9518607998 15984520
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D007251 Influenza, Human Vitamin E 4.7316624496
MESH:D007674 Kidney Diseases Vitamin E 2.9612488133
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008881 Migraine Disorders Valproic Acid 3.4118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.3216359493 8888407
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3316289102 18247401 15754350 16644109 12479363
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3315084515
MESH:D019310 Pseudolymphoma Valproic Acid 5.0611422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9415475178 14763951 11044598 11738929 1511512 16876388 3137016 17978042
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms S 1 (combination) 3.3618506536 18553229 16557585
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04520 Adherens junction
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05217 Basal cell carcinoma
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:05216 Thyroid cancer
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36393
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450626nicotine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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