AutismKB 2.0

Annotation Detail for ABHD11


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Basic Information Top
Gene Symbol:ABHD11 ( WBSCR21 )
Gene Full Name: abhydrolase domain containing 11
Band: 7q11.23
Quick LinksEntrez ID:83451; OMIM: NA; Uniprot ID:ABHDB_HUMAN; ENSEMBL ID: ENSG00000106077; HGNC ID: 16407
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ABHD11 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ABHD11 mRNAdecreases expression 17484886
D002945 Cisplatin ABHD11 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
C006253 pirinixic acid pirinixic acid results in increased expression of ABHD11 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in decreased expression of ABHD11 mRNAdecreases expression 18037150
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.3312690470 15814532 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Cisplatin 2.8217638652 11798837
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.5014601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.9517868700
MESH:D001930 Brain Injuries Progesterone 4.7415845082 15380490 15665606
MESH:D001943 Breast Neoplasms Cisplatin 2.4218382427 19526202
MESH:D001943 Breast Neoplasms Progesterone 2.4216175315 15562024 17614352
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616097048 3786805 16124888 16050911 16011737 16192424 18705752 10355542 15721981 15700767 16227642 15673190
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.853084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8518788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8517982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1316685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.9017066447 6189445 18337622
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003929 Diabetic Neuropathies Progesterone 4.9817187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0212958197 12540782 11287661 14550746 10915739 11529661 14986274 14725611 11834606 12153990 16227642 19739265 16081117 16781746 19416960 10663392 11461765 16485898 18071297 11739529 12705907 11743745 17522070 12392966 11421492 15968718 17906064 18713872 19923254 10774834 16109766 19164858 12594235 2444490 19420014 19370779 19085960 16393943 17562736 16177239 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0221278145 11566570 16177239 2869522 10915739 6884620 7440962 7179309 19085960 10092053 16227642 15027814 19336974 17522070 3786805 7120509 9327722 4309450 6623471 15998439 15968718 3732212
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Cisplatin 4.1112649298 15033597 19839026 12231392
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2217692515
MESH:D004715 Endometriosis Progesterone 4.1116134523
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8415173087 17638652 16785472 16481741 15464296
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9412795759 61145 15959796 19224547 17595544 12631006 16239168 16045604
MESH:D005234 Fatty Liver pirinixic acid 8.9420131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 3.9418705752
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9415464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.6219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7315464296
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 16221962 19772884 19176532
MESH:D006689 Hodgkin Disease Cisplatin 3.9116170182 16200630
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8915869954
MESH:D007249 Inflammation Progesterone 2.7515869954
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.7515464296
MESH:D007674 Kidney Diseases Acetaminophen 6.7412587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 6.7419839026 12231392 18289764 15190930 12649298
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.4111231351
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9811408273 17157831 16943688 11903743 16239168 21278145 17334410 17174718 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4118277467 18210741 14716496 15818738 18006644 18395914 15650968 12898905 12649538 12632512 17944888 17714472 17922224 17805973 17869086 15338365 17823541 13678700 16015684 18187930 15730626 12632514 12666154 18412020 16116963 16192424 20821823 17708605 17698563 18376398 18317297 12958196 14620537 17766677 14512876 16248980 12445418 17761835 18472332 18251166 14724832 17631135 12389079 15996030 15370692 15362042 15931870 18429990 15893842 18156304 14748882 18339082 18472094 15959796 11481614 18263696 17481882 14716833 18166357 16011737 15673190 18418968 17557913 17976157 16638106 18205269 18481824 18395095 12546737 12609069 15925388 17525996 17565644 18420326 16136751 12667390 18054572 18705752 15057751 12445421 17640975 15876570 17900296 12586293 12741479 16097048 16033810 10355542 17721639 18279442 16027843 15123356 15052691
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008107 Liver Diseases Acetaminophen 4.1412969438 16610002 19014921 16611625 19784758 11587558 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1417285989 16246199 16964402 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.5916871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.5916899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8019294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.8020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8115583823 12014681
MESH:D008175 Lung Neoplasms Cisplatin 2.346189445 11798837 17225452
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0717203775 11408345
MESH:D008545 Melanoma Cisplatin 2.5117761969 16432458 18332650 18176117 12883367 12393984 11135225 18505091 12374674 16809738 17023156 16248763 15577323
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.3115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008654 Mesothelioma Cisplatin 3.3617638057
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms Cisplatin 5.6116773208
MESH:D009369 Neoplasms pirinixic acid 5.6117405874
MESH:D009395 Nephritis, Interstitial Cisplatin 5.1015464296
MESH:D009447 Neuroblastoma Cisplatin 3.608761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.248761367
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms Cisplatin 5.4115464296 19769630 6897625 17225452
MESH:D010051 Ovarian Neoplasms Progesterone 5.4117393432 16525653
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0919003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.7515464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.9517638057
MESH:D051437 Renal Insufficiency Cisplatin 4.8915464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9518045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.8714601052
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.9515464296
MESH:D013119 Spinal Cord Injuries Progesterone 4.8215862959 16503802
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 17522103 18396642
MESH:D013736 Testicular Neoplasms Cisplatin 5.0315464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 3.0617225452 12973940 15464296
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.5516803524
MESH:D014625 Vaginal Neoplasms Cisplatin 5.0915577323
MESH:D014839 Vomiting Cisplatin 5.3311897121
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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