AutismKB 2.0

Annotation Detail for ARHGAP24


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Basic Information Top
Gene Symbol:ARHGAP24 ( DKFZp564B1162,FILGAP,FLJ33877,RC-GAP72,RCGAP72,p73,p73RhoGAP )
Gene Full Name: Rho GTPase activating protein 24
Band: 4q21.23-q21.3
Quick LinksEntrez ID:83478; OMIM: 610586; Uniprot ID:RHG24_HUMAN; ENSEMBL ID: ENSG00000138639; HGNC ID: 25361
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by Rho GTPases
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ARHGAP24 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ARHGAP24 mRNAdecreases expression 18648102
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA]decreases expression|decreases reaction 18200517
D004041 Dietary Fats Dietary Fats results in increased expression of ARHGAP24 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ARHGAP24 mRNAincreases expression 19638242
C041786 palm oil palm oil results in increased expression of ARHGAP24 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of ARHGAP24 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARHGAP24 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARHGAP24 mRNAaffects binding|decreases expression|increases activity 19710929
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA]decreases expression|decreases reaction 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNAdecreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Diethylnitrosamine 7.046695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.1117620307 19061943 18056438 19052882 16434500 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.1117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.1116434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6515590663
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7716807698
MESH:D050197 Atherosclerosis Curcumin 3.4318704882
MESH:D001327 Autoimmune Diseases Curcumin 4.7519761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D002545 Brain Ischemia Curcumin 4.6116770732
MESH:D001932 Brain Neoplasms Curcumin 4.1317596214
MESH:D001943 Breast Neoplasms Curcumin 1.9719250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9717474063
MESH:D002277 Carcinoma Curcumin 4.0018593918
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.807296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8018506893 19519916 20214788 16807293 18788625 18393292 16502159 18210153 19208518 18785209 17055752 19171122 20514400 17138121 17978847 16288022 20727157 19539802 16540662 19052882 16830150 17173139 19919837 11831363 19701751 17761372 16569478 17428255 16878318 20935162 18978308 19394651 16328049 20084675 16935385 3084413 10672840 19335982 3581430 18056438 18691550 16681979 20432363 18494052 20524982 19107877 19383236 17162532 20101231 16698587 20007298 19822196 19418558 20512989 16779866 18665156 10737359 21159647 18971187
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.806705139 20007298 17173139 1701930 20935162
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8118462866
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.157505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.152727394 7505956 17174075 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.359022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003092 Colitis Curcumin 10.8318200517 16782535 16804969
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.8316804969 16867261 16474422 17991707 16782535 17936198 18200517 11698051 18023891
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5017276891
MESH:D003103 Coloboma Curcumin 4.7618809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.1618497527
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0614531868 12868966 8970840 8156756 18759878 2524372 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.7418403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.7420387270
MESH:D003928 Diabetic Nephropathies Curcumin 4.1918204486
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.546679447 1440618 9328219 16192314 8291058 9022650 18648102 7440962 18289764 11289319 9653073 6482804 18692083
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5419107877
MESH:D004381 Duodenal Ulcer Curcumin 4.2817351913
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Curcumin 20.5819297423
MESH:D005234 Fatty Liver Dietary Fats 20.5819004024 18296743 17967931 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 20.5820387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 20.5820131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Curcumin 16.6018705752
MESH:D005355 Fibrosis Dietary Fats 16.6018296743
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 16.6017994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9518462866
MESH:D005909 Glioblastoma Curcumin 3.6017596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7918462866 18829502
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3618467677 19772884 19176532 16221962
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3017701891
MESH:D006937 Hypercholesterolemia Curcumin 9.9318704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.9321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007249 Inflammation Curcumin 8.9917151092 16956363 18403477
MESH:D007249 Inflammation Dietary Fats 8.9920412841
MESH:D007249 Inflammation Diethylnitrosamine 8.9918785209
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.9218200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.9218200517
MESH:D007333 Insulin Resistance Dietary Fats 7.6711836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.8617994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.4110783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.946582329
MESH:D007889 Leiomyoma Curcumin 4.7918555241
MESH:D007938 Leukemia Curcumin 3.3318462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4116106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0016106398
MESH:D008103 Liver Cirrhosis Dietary Fats 11.6418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.6419638242 20032147 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 11.6421047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5718705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5715474484
MESH:D008107 Liver Diseases Curcumin 6.8916956363
MESH:D008107 Liver Diseases Diethylnitrosamine 6.8917034775
MESH:D008107 Liver Diseases Phenobarbital 6.8919363144
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8218754104 19833225 20137499 2422723 19256749 15885732 20492335 19427195 19812893 18978307 20405173 20118626 19690152 20501860 10737359 16942905 20452335 19551842 9163691 19073162 18644402 20434301 12771043 19850985 19996281 19090486 19294768 21047994 20101389 19638242 19642983 19254457 21278145 20583210 18977376 19255062 21167192 19426721 19499222 15175105 21071580 12112319 18648771 2862719
MESH:D008113 Liver Neoplasms Phenobarbital 7.8219073162 19812893 21047994 19482888 8742319 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 7.8216377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.586587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5819004024 18282651 18093689 16267830 18253720 16842330 18164116 19519916 21159647 19009564 17174075 19539802 19126423 18308698 2563599 9362446 17854601 18775883 3124819 18544905 17942915 18079962
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.581399818 17172636 18308698 6150874 2563599
MESH:D008175 Lung Neoplasms Curcumin 2.6919359593 18462866 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6920512841 20970405 21163286 6695378
MESH:D008223 Lymphoma Curcumin 3.7318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9516173963
MESH:D008545 Melanoma Curcumin 2.4417885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.3917263510
MESH:D009101 Multiple Myeloma Curcumin 3.6519372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6118495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8512497104
MESH:D009423 Nervous System Neoplasms Curcumin 5.9518462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity Curcumin 7.6919297423
MESH:D009765 Obesity Dietary Fats 7.6920518802 18674790 17217161 20132043 21332399 11836018 19632207 16723640 18457598
MESH:D009765 Obesity pirinixic acid 7.6920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.536482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010024 Osteoporosis Curcumin 3.5918719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8718462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 9.0519196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 9.0516540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 9.0516965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.4217698068
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.712563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.712563599
MESH:D011471 Prostatic Neoplasms Curcumin 3.6518226269 12497104 10851300 18156803 18769126 11398177 15129424
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.7219168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2510666014 18379247
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012509 Sarcoma Curcumin 4.3118462866
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3818551238
MESH:D012640 Seizures Phenobarbital 6.384039156 11442880 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D018805 Sepsis Curcumin 4.2518389075
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Curcumin 3.7016631530 19188055
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.887505956 6582329 6587162 3712494 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.887505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.881399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.778074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.7718593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.5518462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134934054
    • No data
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA164925725Toxic liver disease
    Releated drug ID Related drug Name
    PA452621antineoplastic agents
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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