Gene Symbol:	PUS3 ( 2610020J05Rik,FLJ23638 )
Gene Full Name:	pseudouridylate synthase 3
Band:	11q24.2
Quick Links	Entrez ID:83480; OMIM: NA; Uniprot ID:PUS3_HUMAN; ENSEMBL ID: ENSG00000110060; HGNC ID: 25461
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of PUS3 mRNA	affects expression	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of PUS3 mRNA	affects expression	17562736
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PUS3 mRNA	affects binding\|increases activity\|increases expression	19710929

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D055371	Acute Lung Injury	pirinixic acid	3.64	18653653
MESH:D018248	Adenoma, Liver Cell	pirinixic acid	4.22	16434500
MESH:D000799	Angioedema	Acetaminophen	4.71	10982225
MESH:D001321	Autistic Disorder	Acetaminophen	1.39	18445737
MESH:D001778	Blood Coagulation Disorders	pirinixic acid	3.63	19483382
MESH:D006528	Carcinoma, Hepatocellular	2,4-dinitrotoluene	2.97	16705839
MESH:D006528	Carcinoma, Hepatocellular	Acetaminophen	2.97	3084413
MESH:D002386	Cataract	Acetaminophen	2.81	10977129
MESH:D002779	Cholestasis	pirinixic acid	3.15	19176532
MESH:D003490	Cyanosis	2,4-dinitrotoluene	4.67	18551238
MESH:D003876	Dermatitis, Atopic	pirinixic acid	2.59	18249437
MESH:D056486	Drug-Induced Liver Injury	2,4-dinitrotoluene	4.05	18551238 21346803
MESH:D056486	Drug-Induced Liver Injury	Acetaminophen	4.05	11739529 10915739 12705907 15968718 19416960 19164858 12153990 11834606 18713872 16485898 14725611 16081117 19420014 11421492 12540782 14986274 16781746 17906064 18071297 19370779 14550746 2444490 11743745 16109766 10774834 16393943 10663392 12594235 11461765 12958197 12392966 16227642 15619225 19739265 11529661 19923254 17562736 16177239 17522070 11287661 19085960
MESH:D056487	Drug-Induced Liver Injury, Chronic	Acetaminophen	4.96	19426721
MESH:D004487	Edema	pirinixic acid	2.96	12083418
MESH:D005234	Fatty Liver	pirinixic acid	3.25	19236843 20131406
MESH:D005756	Gastritis	Acetaminophen	4.54	16983495
MESH:D006333	Heart Failure	pirinixic acid	2.78	20558911
MESH:D006529	Hepatomegaly	pirinixic acid	3.64	19176532 16221962 19772884 18467677
MESH:D006930	Hyperalgesia	Acetaminophen	3.06	16870215
MESH:D006943	Hyperglycemia	pirinixic acid	3.63	20558911
MESH:D007333	Insulin Resistance	pirinixic acid	2.90	16306350
MESH:D007674	Kidney Diseases	Acetaminophen	2.42	12587719 15629191
MESH:D007680	Kidney Neoplasms	2,4-dinitrotoluene	3.36	16705839
MESH:D008106	Liver Cirrhosis, Experimental	pirinixic acid	1.35	15474484
MESH:D008107	Liver Diseases	Acetaminophen	1.71	11587558 12969438 16610002 19784758 19460945 16611625 12587719 19014921
MESH:D017114	Liver Failure, Acute	Acetaminophen	3.68	17185352 16871587
MESH:D008113	Liver Neoplasms	pirinixic acid	1.94	20007298 15890375 16377806
MESH:D008546	Melanoma, Experimental	Acetaminophen	4.22	19513568
MESH:D009135	Muscular Diseases	pirinixic acid	4.16	16239165
MESH:D009203	Myocardial Infarction	pirinixic acid	2.29	19151258
MESH:D015428	Myocardial Reperfusion Injury	pirinixic acid	3.29	16411023
MESH:D009336	Necrosis	2,4-dinitrotoluene	4.60	18551238
MESH:D009369	Neoplasms	pirinixic acid	2.12	17405874
MESH:D019636	Neurodegenerative Diseases	Acetaminophen	3.26	18514411
MESH:D009765	Obesity	pirinixic acid	1.89	20558911
MESH:D009784	Occupational Diseases	2,4-dinitrotoluene	3.88	16049721 12819281
MESH:D010146	Pain	Acetaminophen	2.77	16870215
MESH:D015427	Reperfusion Injury	pirinixic acid	2.56	19058328
MESH:D012640	Seizures	2,4-dinitrotoluene	2.81	18551238
MESH:D001749	Urinary Bladder Neoplasms	2,4-dinitrotoluene	2.42	16049721
MESH:D014571	Urologic Neoplasms	2,4-dinitrotoluene	5.06	10091137
MESH:D014581	Urticaria	Acetaminophen	3.50	10982225

AutismKB 2.0

Annotation Detail for PUS3

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics