AutismKB 2.0

Annotation Detail for HIST2H2BE


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Basic Information Top
Gene Symbol:HIST2H2BE ( GL105,H2B,H2B.1,H2BFQ,H2BGL105,H2BQ,MGC119802,MGC119804,MGC129733,MGC129734 )
Gene Full Name: histone cluster 2, H2be
Band: 1q21.2
Quick LinksEntrez ID:8349; OMIM: 601831; Uniprot ID:H2B2E_HUMAN; ENSEMBL ID: ENSG00000184678; HGNC ID: 4760
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
Pathway IDPathway Name
Chromosome Maintenance
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HIST2H2BE mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of HIST2H2BE mRNA]affects expression|affects reaction 19414516
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HIST2H2BE mRNA]affects expression|affects reaction 19414516
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HIST2H2BE mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HIST2H2BE mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HIST2H2BE mRNAdecreases expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HIST2H2BE mRNAincreases expression 20382639
19150397
C006780 bisphenol A bisphenol A results in decreased expression of HIST2H2BE mRNAdecreases expression 16474171
D016572 Cyclosporine Cyclosporine results in increased expression of HIST2H2BE mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of HIST2H2BE mRNAdecreases expression 16474171
D019833 Genistein Genistein results in decreased expression of HIST2H2BE mRNAdecreases expression 16474171
D007529 Isoflavones Isoflavones affects the expression of HIST2H2BE mRNAaffects expression 16365062
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of HIST2H2BE mRNAincreases expression 20024957
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of HIST2H2BE mRNAdecreases expression 16474171
C059514 resveratrol resveratrol results in decreased expression of HIST2H2BE mRNAdecreases expression 19371625
C017947 sodium arsenite sodium arsenite results in increased expression of HIST2H2BE mRNAincreases expression 12679051
D014212 Tretinoin Tretinoin results in increased expression of HIST2H2BE mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 3.8816538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1320464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 7.1311473722
MESH:D000230 Adenocarcinoma Genistein 7.1311473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.866695378
MESH:D000236 Adenoma resveratrol 6.8615688382
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9616712894 17306315
MESH:D000505 Alopecia Isoflavones 9.6517569567
MESH:D000505 Alopecia Tretinoin 9.6515955085
MESH:D000544 Alzheimer Disease resveratrol 2.5716183991 16162502
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001169 Arthritis, Experimental resveratrol 7.5717115116
MESH:D001169 Arthritis, Experimental Tretinoin 7.5716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3516456186
MESH:D050197 Atherosclerosis resveratrol 3.2917967414 16873680
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6416197459 16206674
MESH:D001862 Bone Resorption bisphenol A 3.8911985600
MESH:D002545 Brain Ischemia resveratrol 4.3317600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9820146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.9817123778
MESH:D001943 Breast Neoplasms Estradiol 2.9816675129 17289903 17261762 12948864 18497071 19861407 14630087 17018787
MESH:D001943 Breast Neoplasms Genistein 2.9816873071 17200150 16541309
MESH:D001943 Breast Neoplasms resveratrol 2.9817651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tretinoin 2.9816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.9416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.9416924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.9416227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.9416507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.941917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.0417123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.6416675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.8820419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.8816227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.8818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.8816051514 16096774
MESH:D002318 Cardiovascular Diseases Genistein 12.4616332659
MESH:D002318 Cardiovascular Diseases Isoflavones 12.4617689850
MESH:D002318 Cardiovascular Diseases resveratrol 12.4615458977
MESH:D002386 Cataract Tretinoin 3.1117460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.3320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.3312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.3318566989
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 21.3319716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 21.3320056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D002779 Cholestasis Cyclosporine 2.9419486331
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tretinoin 2.689407595
MESH:D003092 Colitis resveratrol 9.7716474422
MESH:D003092 Colitis Tretinoin 9.7717035595
MESH:D003110 Colonic Neoplasms Genistein 3.9517182828
MESH:D003110 Colonic Neoplasms resveratrol 3.9516338953
MESH:D015179 Colorectal Neoplasms Isoflavones 3.7417116718
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.7415531428
MESH:D015179 Colorectal Neoplasms resveratrol 3.7416550006
MESH:D003327 Coronary Disease resveratrol 3.7716507316
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8217551590 14991402 16925845 9664655 10589399 9142499 9224671 8800419 9125849 9211117
MESH:D003704 Dementia Polychlorinated Biphenyls 4.7316140633
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7916873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D003928 Diabetic Nephropathies Estradiol 9.1019279558
MESH:D003928 Diabetic Nephropathies resveratrol 9.1016286809
MESH:D004487 Edema resveratrol 3.398985016
MESH:D004489 Edema, Cardiac Tretinoin 4.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.0617872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Estradiol 12.5811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 12.5811473722
MESH:D016889 Endometrial Neoplasms Tretinoin 12.5816569247
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8917923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3716530937
MESH:D005124 Eye Abnormalities Tretinoin 3.609664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 2.8819224547
MESH:D005355 Fibrosis Cyclosporine 8.8312639820 12168785
MESH:D005355 Fibrosis Tretinoin 8.8317994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Genistein 7.2716598420
MESH:D005909 Glioblastoma Tretinoin 7.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7020471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.709664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D006561 Herpes Simplex resveratrol 4.2316876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D019584 Hot Flashes Estradiol 10.6317088409
MESH:D019584 Hot Flashes Isoflavones 10.6317290160 14716179
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D006937 Hypercholesterolemia resveratrol 4.0317188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006949 Hyperlipidemias resveratrol 4.0616873680
MESH:D006973 Hypertension Cyclosporine 2.1110903974
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6917600658
MESH:D007248 Infertility, Male sodium arsenite 3.0115346721 12646999
MESH:D007249 Inflammation resveratrol 2.8616366677
MESH:D007251 Influenza, Human resveratrol 4.6116624496
MESH:D007333 Insulin Resistance bisphenol A 7.5016393666
MESH:D007333 Insulin Resistance Estradiol 7.5016627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9317551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 10.1518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.1515618244
MESH:D007674 Kidney Diseases sodium arsenite 10.1520008137
MESH:D007680 Kidney Neoplasms Cyclosporine 7.3512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.3515610895
MESH:D007938 Leukemia Genistein 6.4617468513 18980019
MESH:D007938 Leukemia Tretinoin 6.4617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0816294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.8316087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.8316823087 17506722 17712046 19225113 16788101 17217047 19035177 16331271 19642359 16935935 9834237 19029980 19075265 17368321 17107899 15748426 17294898 12679006 17649720 16766008 16891316 17301526 17361223 16140955 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5717823541
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5718397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5821137059 20195826
MESH:D008113 Liver Neoplasms resveratrol 7.5819812893 19321006 20405173 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 7.5816712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 3.621423854
MESH:D008171 Lung Diseases sodium arsenite 3.1919095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0617365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4318816296 6695378 20064080 20135361 20464547 17053015 18569708 20869020 18520028
MESH:D008175 Lung Neoplasms sodium arsenite 2.4316712894 19931552 17306315 17077188 15276417
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3317088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.3015688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.1516891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.1512929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 10.1511606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma resveratrol 5.1917992120
MESH:D008545 Melanoma sodium arsenite 5.1919082730 16487513
MESH:D008545 Melanoma Tretinoin 5.1916752155
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1918303189 16966607 16166281
MESH:D008659 Metabolic Diseases resveratrol 4.4117112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D020326 Migraine without Aura Cyclic AMP 5.1911304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009101 Multiple Myeloma resveratrol 3.4914749477 17164350 16490592 16267019 17935668 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9217962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0917596541
MESH:D009203 Myocardial Infarction Genistein 6.0417141266
MESH:D009203 Myocardial Infarction resveratrol 6.0417125593 16525036 16317513 17188708 17015251 16456233
MESH:D017202 Myocardial Ischemia resveratrol 4.0317125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.5817141266
MESH:D009205 Myocarditis resveratrol 4.8117322642
MESH:D009369 Neoplasms Benzo(a)pyrene 8.3411141357
MESH:D009369 Neoplasms sodium arsenite 8.3411559025
MESH:D009369 Neoplasms Tretinoin 8.3416594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 9.378985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.3720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 23.8116427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 23.8116427766 11399458
MESH:D009421 Nervous System Malformations Genistein 23.8116427766
MESH:D009421 Nervous System Malformations Tretinoin 23.819125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.3712854658
MESH:D009436 Neural Tube Defects Tretinoin 7.379142499
MESH:D019636 Neurodegenerative Diseases resveratrol 3.8317652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.4317929310
MESH:D010024 Osteoporosis Genistein 7.6519401787
MESH:D010024 Osteoporosis Isoflavones 7.6516562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.2616169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.2617513867
MESH:D010049 Ovarian Diseases bisphenol A 5.0411985600
MESH:D010051 Ovarian Neoplasms Estradiol 11.3719401270
MESH:D010051 Ovarian Neoplasms Genistein 11.3719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.3717306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 11.3716936753
MESH:D010146 Pain Tretinoin 2.9216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4715976015
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4016702228
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9310923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.0410548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.0416679765
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.6520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.6520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4816740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.4816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.4815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Isoflavones 2.4817374662 17571952 17219775 16365062
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4815721890
MESH:D011471 Prostatic Neoplasms resveratrol 2.4817804756 15767336 17675339 16731767 17636462 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4816039940
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.8410548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0415814490 17365031 17322281 17975199
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.6516325855
MESH:D015427 Reperfusion Injury resveratrol 3.2816314181 17058453 15827377 16317513 17520802
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1316116481 16283617
MESH:D012871 Skin Diseases monomethylarsonous acid 3.3817431481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.7010029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 13.7015837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 13.7018572023 19524636
MESH:D012878 Skin Neoplasms Tretinoin 13.7016467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8212854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.352093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3517261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5116321402
MESH:D019966 Substance-Related Disorders bisphenol A 4.0316684133 16045194
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014062 Tongue Neoplasms resveratrol 10.0016227395
MESH:D014062 Tongue Neoplasms Tretinoin 10.0016051514
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5117053015
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 8.5120375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.5116452187 11723127 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms resveratrol 16.0617473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.0611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 16.0616129372
MESH:D014591 Uterine Diseases bisphenol A 5.0714652134
MESH:D014594 Uterine Neoplasms resveratrol 4.1717044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.3417488730
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:22172 Chromosome Maintenance
REACT:27271 Meiotic Recombination
REACT:27235 Meiotic Recombination (mouse)
KEGG:05322 Systemic lupus erythematosus
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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