AutismKB 2.0

Annotation Detail for RASSF5


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Basic Information Top
Gene Symbol:RASSF5 ( MGC10823,MGC17344,Maxp1,NORE1,NORE1A,NORE1B,RAPL,RASSF3 )
Gene Full Name: Ras association (RalGDS/AF-6) domain family member 5
Band: 1q32.1
Quick LinksEntrez ID:83593; OMIM: 607020; Uniprot ID:RASF5_HUMAN; ENSEMBL ID: ENSG00000136653; HGNC ID: 17609
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05223Non-small cell lung cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RASSF5 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RASSF5 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RASSF5 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RASSF5 mRNAdecreases expression 19150397
D004958 Estradiol Estradiol affects the expression of RASSF5 mRNAaffects expression 15598610
D005419 Flavonoids Flavonoids results in increased expression of RASSF5 mRNAincreases expression 18035473
D026023 Permethrin Permethrin results in increased expression of RASSF5 mRNAincreases expression 19017407
D010634 Phenobarbital Phenobarbital results in increased expression of RASSF5 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in decreased expression of RASSF5 mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Estradiol 2.1212948864 18497071 16675129 17018787 19861407 14630087 17289903 17261762
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8016924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.8017173139 6705139 20007298 1701930 20935162
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.986135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D019465 Craniofacial Abnormalities Permethrin 3.1819861644
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact Permethrin 5.2114617103
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0318551238 21346803
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.1119148513 11473722 18566989
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver pirinixic acid 2.9719236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3618467677 19176532 16221962 19772884
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D007249 Inflammation Flavonoids 2.7417296493
MESH:D007299 Insect Bites and Stings Permethrin 6.1412971516 12749493 15189238
MESH:D007333 Insulin Resistance Estradiol 7.6216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.6216306350
MESH:D007674 Kidney Diseases Estradiol 2.6915618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4216705839
MESH:D007680 Kidney Neoplasms Estradiol 13.4215610895
MESH:D007938 Leukemia Permethrin 4.2212937054
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0021047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3515474484
MESH:D008107 Liver Diseases Phenobarbital 2.2119363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.807678174
MESH:D008113 Liver Neoplasms Phenobarbital 7.808742319 21047994 19482888 19812893 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 7.8015890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.352876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.3517172636 6150874 1399818 18308698 2563599
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6816891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 3.8911399458 16427766
MESH:D009447 Neuroblastoma marker/mechanism 18452173
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5516965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,4-dinitrotoluene 10.6118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.6118551238
MESH:D012640 Seizures Phenobarbital 10.6111442880 4039156 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.211399818
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
Pathway ID Pathway Name
KEGG:04670 Leukocyte transendothelial migration
KEGG:05223 Non-small cell lung cancer
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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