AutismKB 2.0

Annotation Detail for SOX7


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Basic Information Top
Gene Symbol:SOX7 ( MGC10895 )
Gene Full Name: SRY (sex determining region Y)-box 7
Band: 8p23.1
Quick LinksEntrez ID:83595; OMIM: 612202; Uniprot ID:SOX7_HUMAN; ENSEMBL ID: ENSG00000171056; HGNC ID: 18196
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SOX7 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in increased expression of SOX7 mRNAincreases expression 18042831
D007213 Indomethacin Indomethacin results in decreased expression of SOX7 mRNAdecreases expression 16984733
C041786 palm oil palm oil results in increased expression of SOX7 mRNAincreases expression 18042831
D011374 Progesterone NCOA2 protein affects the reaction [Progesterone results in decreased expression of SOX7 mRNA]affects reaction|decreases expression 17556502
D011374 Progesterone Progesterone results in decreased expression of SOX7 mRNAdecreases expression 17556502
C017947 sodium arsenite sodium arsenite results in increased expression of SOX7 mRNAincreases expression 20308225
D014212 Tretinoin Tretinoin results in increased expression of SOX7 mRNAincreases expression 17138961
D014212 Tretinoin Tretinoin results in increased expression of SOX7 mRNAincreases expression 16604517
D002762 Cholecalciferol Cholecalciferol results in increased expression of SOX7 mRNAincreases expression 17170073
D002762 Cholecalciferol Cholecalciferol results in increased expression of SOX7 proteinincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Indomethacin 2.8316537180
MESH:D000236 Adenoma Indomethacin 3.5811497255
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2817306315 16712894
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.7517225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7417627676 15579461
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001014 Aortic Aneurysm Indomethacin 5.1310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.1810388637
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D018771 Arthralgia Indomethacin 5.552160914
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.9311248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.9316292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.3416142846
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001477 Bartter Syndrome Indomethacin 5.2910684365
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8516197459 16206674
MESH:D001929 Brain Edema Indomethacin 5.4011481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615665606 15380490 15845082
MESH:D002545 Brain Ischemia Indomethacin 4.7512524144
MESH:D001943 Breast Neoplasms Dietary Fats 2.0320435547
MESH:D001943 Breast Neoplasms Indomethacin 2.0317401462
MESH:D001943 Breast Neoplasms Progesterone 2.0316175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tretinoin 2.0316443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002056 Burns Indomethacin 5.0110459503
MESH:D002100 Cachexia Indomethacin 5.3415625704 15141370 11239499 16537180
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.863084413
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 6.8616391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.8615276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.861917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.0611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.6914736730 11352223 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4717341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.9715482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.9718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.9716096774 16051514
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Tretinoin 7.6617460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002764 Cholecystitis Indomethacin 5.5511181007
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D003110 Colonic Neoplasms Indomethacin 2.6215637740 15936596 11260862 15963497 15625704 15786552
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3618059344 11197048 12606626 17054584
MESH:D018352 Coronavirus Infections Indomethacin 6.0917302372
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839224671 17551590 9211117 8800419 14991402 10589399 9664655 16925845 9142499 9125849
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D003967 Diarrhea Indomethacin 4.077907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6418071297 11739529 2444490 12540782 12958197 19416960 16109766 19420014 16081117 11743745 11287661 11529661 12705907 11461765 19370779 12153990 17522070 10663392 11421492 19739265 15619225 18713872 17562736 12594235 16177239 14550746 19085960 16393943 15968718 10774834 12392966 14725611 16781746 11834606 16227642 17906064 14986274 19164858 16485898 10915739 19923254
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.4918446180 17190690 16133044 12774134 18043480 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 4.4211991626 11595415 17329845 17351913 17151854 11595431 11535926 17202747 16699067 17045617 10671773
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema Indomethacin 3.7416100529 8985016 7907874 7990266 8273558 10653021 19703484
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0617692515
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004715 Endometriosis Indomethacin 10.1115652904
MESH:D004715 Endometriosis Progesterone 10.1116134523
MESH:D019446 Endotoxemia Indomethacin 4.8418509659
MESH:D004751 Enteritis Indomethacin 5.1216328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.2917980183
MESH:D004802 Eosinophilia Indomethacin 4.3611298111
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8511005569
MESH:D005124 Eye Abnormalities Tretinoin 3.759664655 16938888
MESH:D005234 Fatty Liver Dietary Fats 3.4818296743 17967931 19551842 19004024
MESH:D005334 Fever Indomethacin 4.3510431976 17627676 11852909
MESH:D005354 Fibrosarcoma Indomethacin 5.2310962813
MESH:D005355 Fibrosis Dietary Fats 16.7918296743
MESH:D005355 Fibrosis Indomethacin 16.7917994277
MESH:D005355 Fibrosis Tretinoin 16.7917994277
MESH:D005499 Folliculitis Indomethacin 5.5511298111
MESH:D005756 Gastritis Acetaminophen 12.4416983495
MESH:D005756 Gastritis Indomethacin 12.4415046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D005909 Glioblastoma Indomethacin 7.8212870263
MESH:D005909 Glioblastoma Tretinoin 7.8217312396
MESH:D005910 Glioma Indomethacin 3.3016487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.4811849393
MESH:D006073 Gout Indomethacin 5.6911248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 8.4415482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0114991402 9664655
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.8115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.9615135802
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D006930 Hyperalgesia Acetaminophen 14.2216870215
MESH:D006930 Hyperalgesia Indomethacin 14.2212727271
MESH:D006930 Hyperalgesia Tretinoin 14.2216870215
MESH:D034321 Hyperamylasemia Indomethacin 6.0917883296
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006940 Hyperemia Indomethacin 5.3412524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006949 Hyperlipidemias Dietary Fats 10.2221332399
MESH:D006949 Hyperlipidemias Indomethacin 10.2217546600
MESH:D007077 Ileal Diseases Indomethacin 5.4018306037 10574470
MESH:D007079 Ileitis Indomethacin 5.6910651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.7516133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007248 Infertility, Male sodium arsenite 3.1415346721 12646999
MESH:D007249 Inflammation Dietary Fats 9.1320412841
MESH:D007249 Inflammation Indomethacin 9.137812673 12568917 3291741
MESH:D007249 Inflammation Progesterone 9.1315869954
MESH:D007333 Insulin Resistance Dietary Fats 3.2511836018 18457598
MESH:D007410 Intestinal Diseases Indomethacin 10.9310210152 11686837 17994277 11855677 17329856 15831440 18236018 11713966 15610444
MESH:D007410 Intestinal Diseases Tretinoin 10.9317994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.7515241188
MESH:D007569 Jaw Abnormalities Tretinoin 4.1415992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 5.4018306037 16133968 10574470
MESH:D007674 Kidney Diseases Acetaminophen 10.8815629191 12587719
MESH:D007674 Kidney Diseases Indomethacin 10.8817190690
MESH:D007674 Kidney Diseases sodium arsenite 10.8820008137
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.1012228301 11703811 10320625
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.1015631656 16572323 10785260
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.1818360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.1816294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3019075265 17649720 17506722 17368321 12679006 17712046 17361223 17107899 16331271 16891316 15748426 16140955 19225113 9834237 16766008 17294898 16935935 19642359 19029980 16823087 17301526 17217047 17339181 16788101 19035177
MESH:D007964 Leukocytosis Indomethacin 5.7516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.0917980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.0911479899
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.7818194892
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7818397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 19460945 11587558 19784758 12587719 16611625 16610002 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms sodium arsenite 2.4416712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D008175 Lung Neoplasms Indomethacin 2.7711497255 16537180 11053908
MESH:D008175 Lung Neoplasms sodium arsenite 2.7715276417 16712894 17077188 17306315 19931552
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0117203775 11408345
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma sodium arsenite 3.4516487513 19082730
MESH:D008545 Melanoma Tretinoin 3.4516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D008881 Migraine Disorders Indomethacin 3.8411903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.1712636206
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2511053908 11239499 16537180
MESH:D009369 Neoplasms sodium arsenite 5.4611559025
MESH:D009369 Neoplasms Tretinoin 5.4616594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 10.3215625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 10.3220056578
MESH:D009421 Nervous System Malformations Tretinoin 4.069125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.8112854658
MESH:D009436 Neural Tube Defects Tretinoin 7.819142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0918514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 9.0912349958
MESH:D009765 Obesity Dietary Fats 2.3318457598 18674790 17217161 19632207 16723640 20132043 21332399 11836018 20518802
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.556374098
MESH:D010003 Osteoarthritis Indomethacin 3.807009135
MESH:D010051 Ovarian Neoplasms Progesterone 8.2916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.2915276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 8.2916936753
MESH:D010146 Pain Acetaminophen 12.4716870215
MESH:D010146 Pain Indomethacin 12.4713679232 17627676 3291741 17440234
MESH:D010146 Pain Tretinoin 12.4716870215
MESH:D010149 Pain, Postoperative Indomethacin 5.0612538197 18702446
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D010195 Pancreatitis Indomethacin 4.1817883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.0916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.3512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.0911903285
MESH:D010437 Peptic Ulcer Indomethacin 5.4911148446
MESH:D010518 Periodontitis Indomethacin 5.2917225004
MESH:D047928 Premature Birth Indomethacin 5.4317000239
MESH:D011471 Prostatic Neoplasms Cholecalciferol 3.5917024972
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.5916039940
MESH:D011507 Proteinuria Indomethacin 10.2211849393
MESH:D011507 Proteinuria Tretinoin 10.2216636307
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D012878 Skin Neoplasms sodium arsenite 6.1319524636 18572023
MESH:D012878 Skin Neoplasms Tretinoin 6.1316467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.6216503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9812854658
MESH:D013272 Stomach Diseases Indomethacin 4.7510192188 18545984 17160473 15472012 18209964 16280098 10486359 10215738 17638125 16184426 16113693 17207306 15038085
MESH:D013274 Stomach Neoplasms Indomethacin 2.6915609394
MESH:D013274 Stomach Neoplasms Tretinoin 2.6917261132
MESH:D013276 Stomach Ulcer Indomethacin 3.8211595415 1323529 16252198 10750652 11523592 16631530 18087811 17918041 12500499 10423059 11145282 18726076 15138204 10878458 18299717 11906479 11729361 17977527 15104355 18181030 18237397 12787963 15255614 17654042 17135157 16150113 11595431 17895592 17627676 18209962 18431645 16397915 16755016 16934674 12498302 18543354 17657623 12467913 16169175 14567935 12077510 18193104
MESH:D013964 Thyroid Neoplasms Indomethacin 8.0011352223 14736730 18791128
MESH:D013964 Thyroid Neoplasms Tretinoin 8.0016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D014456 Ulcer Indomethacin 5.2317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5811723127 17306315 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.1811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.1816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D014839 Vomiting Indomethacin 5.1211897121
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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