AutismKB 2.0

Annotation Detail for SESN2


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Basic Information Top
Gene Symbol:SESN2 ( DKFZp761M0212,DKFZp761M02121,HI95,SES2,SEST2 )
Gene Full Name: sestrin 2
Band: 1p35.3
Quick LinksEntrez ID:83667; OMIM: 607767; Uniprot ID:SESN2_HUMAN; ENSEMBL ID: ENSG00000130766; HGNC ID: 20746
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04115p53 signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of SESN2 mRNAincreases expression 20359517
C120508 A 192621 A 192621 results in increased expression of SESN2 mRNAincreases expression 19040731
D000082 Acetaminophen Acetaminophen affects the expression of SESN2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SESN2 proteinaffects expression 20106945
C103505 AM 251 AM 251 results in increased expression of SESN2 mRNAincreases expression 16500647
D000638 Amiodarone Amiodarone results in increased expression of SESN2 mRNAincreases expression 19774075
D001554 Benzene Benzene results in increased expression of SESN2 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SESN2 mRNAincreases expression 20106945
20064835
D016572 Cyclosporine Cyclosporine results in increased expression of SESN2 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of SESN2 mRNAincreases expression 20106945
C004912 ethylbenzene ethylbenzene results in increased expression of SESN2 mRNAincreases expression 20359517
C051890 irinotecan irinotecan metabolite results in increased expression of SESN2 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of SESN2 mRNAincreases expression 15956246
D008752 Methylene Chloride Methylene Chloride results in increased expression of SESN2 mRNAincreases expression 20359517
D011374 Progesterone Progesterone results in increased expression of SESN2 mRNAincreases expression 18037150
D014050 Toluene Toluene results in increased expression of SESN2 mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of SESN2 mRNAincreases expression 20359517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.2811473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D000741 Anemia, Aplastic Benzene 4.3711369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8018218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 3.9019698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 3.9019483382
MESH:D001836 Body Weight Changes 2-xylene 5.957457028
MESH:D001855 Bone Marrow Diseases Benzene 5.2616183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715380490 15665606 15845082
MESH:D001943 Breast Neoplasms Benzene 2.9811921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9820146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.9812948864 17261762 18497071 16675129 14630087 17289903 17018787 19861407
MESH:D001943 Breast Neoplasms Methylene Chloride 2.9815986119
MESH:D001943 Breast Neoplasms Progesterone 2.9816175315 15562024 17614352
MESH:D001943 Breast Neoplasms Trichloroethylene 2.9815986119
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.543084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.5412619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5416924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8919225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1018974383
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.5818566989
MESH:D002547 Cerebral Palsy Toluene 5.879294310
MESH:D002779 Cholestasis Cyclosporine 2.9219486331
MESH:D003110 Colonic Neoplasms irinotecan 2.5917725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3616391804 15273666 16303861 17454858 17159606 18259882 18509181
MESH:D019465 Craniofacial Abnormalities Benzene 3.2715643154
MESH:D019465 Craniofacial Abnormalities Toluene 3.279294310
MESH:D003643 Death Toluene 5.706431079
MESH:D003872 Dermatitis Benzene 4.7815902427
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4116081117 17522070 16177239 11421492 14986274 15968718 18713872 19370779 11461765 10774834 11287661 16485898 12153990 19164858 19085960 2444490 12540782 19923254 17906064 16393943 10663392 19420014 11834606 12594235 18071297 15619225 16227642 17562736 19416960 12392966 14725611 16109766 16781746 11529661 19739265 14550746 12958197 11743745 12705907 10915739 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.4115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 6.417120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7917692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.9811473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 3.7716134523
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005234 Fatty Liver Amiodarone 7.8514986274
MESH:D005234 Fatty Liver Cyclosporine 7.8519224547
MESH:D005355 Fibrosis Cyclosporine 3.1512168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6620471113
MESH:D006402 Hematologic Diseases Benzene 4.6616183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006529 Hepatomegaly 2-xylene 9.377457013 7457028
MESH:D006529 Hepatomegaly Amiodarone 9.3715265979
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.889751232 8137927
MESH:D006973 Hypertension Benzene 5.3817940673
MESH:D006973 Hypertension Cyclosporine 5.3810903974
MESH:D007037 Hypothyroidism Amiodarone 4.5317991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007249 Inflammation Progesterone 2.6015869954
MESH:D007333 Insulin Resistance Estradiol 2.9716393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.9815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.9818776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.9815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.2815610895
MESH:D007938 Leukemia Benzene 3.3918335105 17119257 14694614 15935818
MESH:D007951 Leukemia, Myeloid Benzene 4.3217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7019478238
MESH:D008064 Lipidoses Amiodarone 3.5117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6714659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6312587719 19014921 11587558 19784758 16611625 16610002 19460945 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.5615890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5621137059 20195826
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.148603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 10.1412562636
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 10.147955063
MESH:D008133 Long QT Syndrome Amiodarone 3.5811989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.3712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 11.5718516814
MESH:D017563 Lung Diseases, Interstitial Benzene 11.5714698565
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9614755239
MESH:D008175 Lung Neoplasms Benzene 4.9612562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9620869020 20135361 18569708 17053015 18816296 18520028 20464547 6695378 20064080
MESH:D008175 Lung Neoplasms Methylene Chloride 4.9615172992
MESH:D008223 Lymphoma Benzene 3.7417119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.4612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 10.0811921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.0811807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.0817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008607 Mental Retardation Toluene 3.659294310
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D019957 Motor Skills Disorders Toluene 5.249294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D052016 Mucositis irinotecan 5.0317159606
MESH:D009101 Multiple Myeloma Benzene 3.6617119195
MESH:D009181 Mycoses Amiodarone 4.9312754197 17974566
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D009362 Neoplasm Metastasis irinotecan 3.1718259882
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4111141357
MESH:D009369 Neoplasms Trichloroethylene 5.4111911487
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.6616427766 11399458
MESH:D009436 Neural Tube Defects Benzene 3.6715643154
MESH:D009447 Neuroblastoma irinotecan 3.488761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.758761367
MESH:D009784 Occupational Diseases Benzene 4.1817119257 17479406 15727169 15913788 15612468 15935809 16737584 17178637 15576619
MESH:D010051 Ovarian Neoplasms Benzene 7.9812562636
MESH:D010051 Ovarian Neoplasms Estradiol 7.9819401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.9816525653 17393432
MESH:D010146 Pain Acetaminophen 7.1016870215
MESH:D010146 Pain AM 251 7.1018987195
MESH:D010190 Pancreatic Neoplasms AM 251 3.8416500647
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1116740699
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8511597910 12832656 12490602
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012640 Seizures Toluene 3.726431079 9294310
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1018724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3719755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.3016503802 15862959
MESH:D013274 Stomach Neoplasms Benzene 3.4912562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.492093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 3.4915723263
MESH:D013276 Stomach Ulcer Amiodarone 3.3218087811
MESH:D013610 Tachycardia Amiodarone 4.3011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2019225199
MESH:D013733 Testicular Diseases Toluene 4.9810514026 10048760
MESH:D013953 Thymus Neoplasms Benzene 4.9810850423
MESH:D013959 Thyroid Diseases Amiodarone 4.7919731979
MESH:D013971 Thyrotoxicosis Amiodarone 4.8718020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D016171 Torsades de Pointes Amiodarone 4.2117467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1817053015
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Benzene 4.3412562636
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:04115 p53 signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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