AutismKB 2.0

Annotation Detail for YPEL3


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Basic Information Top
Gene Symbol:YPEL3 ( MGC10500 )
Gene Full Name: yippee-like 3 (Drosophila)
Band: 16p11.2
Quick LinksEntrez ID:83719; OMIM: 609724; Uniprot ID:YPEL3_HUMAN; ENSEMBL ID: ENSG00000090238; HGNC ID: 18327
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003474 Curcumin Curcumin results in decreased expression of YPEL3 mRNAdecreases expression 17198877
D016572 Cyclosporine Cyclosporine results in decreased expression of YPEL3 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of YPEL3 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5911752688 14514962 15322242
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.9517887948
MESH:D000544 Alzheimer Disease Curcumin 2.6915590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8116807698
MESH:D050197 Atherosclerosis Curcumin 3.5518704882
MESH:D001327 Autoimmune Diseases Curcumin 5.1419761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D002545 Brain Ischemia Curcumin 5.0716770732
MESH:D001932 Brain Neoplasms Curcumin 4.3817596214
MESH:D001943 Breast Neoplasms Curcumin 2.1218462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D002277 Carcinoma Curcumin 9.5218593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.5216835633
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0918414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8518462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5818670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.8212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2512621046 8697196 15668235 16354765 15340226
MESH:D003092 Colitis Curcumin 4.8318200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 5.0318809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5619359593 16340194
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.5518497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.6918403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6917107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.4318204486
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004381 Duodenal Ulcer Curcumin 4.6317351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7718230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005234 Fatty Liver Curcumin 9.5519297423
MESH:D005234 Fatty Liver Cyclosporine 9.5519224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Curcumin 18.9718705752
MESH:D005355 Fibrosis Cyclosporine 18.9712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.9720067830
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.3518462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D005909 Glioblastoma Curcumin 3.7417596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.9418462866 18829502
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5310048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5412621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.6917701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.9116354765 18606429 16959395 8697196 15340226
MESH:D006937 Hypercholesterolemia Curcumin 4.5418704882
MESH:D006973 Hypertension Cyclosporine 5.3910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3918670907 18850075
MESH:D007249 Inflammation Curcumin 5.7516956363 18403477 17151092
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.7512878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3418200517 18596194
MESH:D007414 Intestinal Neoplasms Curcumin 4.6710783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.568314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.1212371664
MESH:D007889 Leiomyoma Curcumin 5.1018555241
MESH:D007938 Leukemia Curcumin 3.4218462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.6916106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.3516106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5817355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5812878042
MESH:D008107 Liver Diseases Curcumin 2.6916956363
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3512151625
MESH:D008175 Lung Neoplasms Curcumin 2.5419359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5411884234 19555203
MESH:D008223 Lymphoma Curcumin 3.8918462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.3516173963
MESH:D008545 Melanoma Curcumin 2.4617885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.7417263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D009101 Multiple Myeloma Curcumin 3.8219372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.6617962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D009361 Neoplasm Invasiveness Curcumin 4.9518495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.4012497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7018481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D009423 Nervous System Neoplasms Curcumin 6.5018462866
MESH:D009765 Obesity Curcumin 2.8219297423
MESH:D010024 Osteoporosis Curcumin 3.7118719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9218462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0519196508 19401701 17440100
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Curcumin 3.6115129424 18769126 12497104 10851300 11398177 18226269 18156803
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.9819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.5518379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012509 Sarcoma Curcumin 4.5618462866
MESH:D018805 Sepsis Curcumin 4.4618389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013276 Stomach Ulcer Curcumin 3.9719188055 16631530
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D001749 Urinary Bladder Neoplasms Curcumin 3.0218593936
MESH:D014565 Urogenital Neoplasms Curcumin 6.0118462866
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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