Gene Symbol:	ITCH ( AIF4,AIP4,NAPP1,dJ468O1.1 )
Gene Full Name:	itchy E3 ubiquitin protein ligase homolog (mouse)
Band:	20q11.22
Quick Links	Entrez ID:83737; OMIM: 606409; Uniprot ID:ITCH_HUMAN; ENSEMBL ID: ENSG00000078747; HGNC ID: 13890
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
200039	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
200009	ErbB4 signaling events
200013	Notch signaling pathway
200083	CXCR4-mediated signaling events
200195	TGF-beta receptor signaling

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene results in decreased expression of ITCH mRNA	decreases expression	20406850
D000082	Acetaminophen	Acetaminophen affects the expression of ITCH mRNA	affects expression	17562736
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ITCH mRNA	decreases expression	19150397 20018196
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of ITCH mRNA	increases expression	15336504
D016572	Cyclosporine	Cyclosporine results in increased expression of ITCH mRNA	increases expression	20106945
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of ITCH mRNA	decreases expression	18175754

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000799	Angioedema		Acetaminophen	4.36	10982225
MESH:D001321	Autistic Disorder		Acetaminophen	1.40	18445737
OMIM:613385	AUTOIMMUNE DISEASE, SYNDROMIC MULTISYSTEM	marker/mechanism
MESH:D006528	Carcinoma, Hepatocellular		2,6-dinitrotoluene	2.94	16705839
MESH:D006528	Carcinoma, Hepatocellular		Acetaminophen	2.94	3084413
MESH:D002386	Cataract		Acetaminophen	2.75	10977129
MESH:D002471	Cell Transformation, Neoplastic		2,6-dinitrotoluene	12.37	6135515
MESH:D002471	Cell Transformation, Neoplastic		7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	12.37	20889678
MESH:D002471	Cell Transformation, Neoplastic		Cyclosporine	12.37	12371664
MESH:D002779	Cholestasis		Cyclosporine	3.14	19486331
MESH:D019457	Chromosome Breakage		Sodium Selenite	5.17	15894690
MESH:D003490	Cyanosis		2,6-dinitrotoluene	4.44	18551238
MESH:D003920	Diabetes Mellitus		Sodium Selenite	4.06	16285004
MESH:D056486	Drug-Induced Liver Injury		2,6-dinitrotoluene	6.67	18551238 21346803
MESH:D056486	Drug-Induced Liver Injury		Acetaminophen	6.67	15968718 18713872 10915739 19923254 18071297 12392966 17522070 2444490 16109766 12540782 16781746 10663392 17906064 14550746 16227642 15619225 11834606 10774834 12958197 12153990 19416960 19420014 14725611 11743745 19739265 11739529 16081117 11529661 14986274 16393943 19085960 19164858 11461765 19370779 11421492 12594235 11287661 17562736 12705907 16485898 16177239
MESH:D056486	Drug-Induced Liver Injury		Sodium Selenite	6.67	15131321
MESH:D056487	Drug-Induced Liver Injury, Chronic		Acetaminophen	4.62	19426721
MESH:D004938	Esophageal Neoplasms		7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	2.13	20426865
MESH:D005234	Fatty Liver		Cyclosporine	3.18	19224547
MESH:D005355	Fibrosis		Cyclosporine	3.56	12639820 12168785
MESH:D005756	Gastritis		Acetaminophen	4.19	16983495
MESH:D005885	Gingival Hyperplasia		Cyclosporine	4.68	8708960
MESH:D006457	Hemoglobinuria, Paroxysmal		Cyclosporine	4.88	15720958
MESH:D006930	Hyperalgesia		Acetaminophen	2.95	16870215
MESH:D006973	Hypertension		Cyclosporine	2.19	10903974
MESH:D007333	Insulin Resistance		Sodium Selenite	3.47	14714311
MESH:D007638	Keratoconjunctivitis Sicca		Cyclosporine	4.96	15604871
MESH:D007674	Kidney Diseases		Acetaminophen	6.34	12587719 15629191
MESH:D007674	Kidney Diseases		Cyclosporine	6.34	8314463 10903974 18776723
MESH:D007680	Kidney Neoplasms		2,6-dinitrotoluene	8.18	16705839
MESH:D007680	Kidney Neoplasms		Cyclosporine	8.18	12371664
MESH:D008107	Liver Diseases		Acetaminophen	1.69	16610002 12969438 12587719 19784758 11587558 19460945 16611625 19014921
MESH:D017114	Liver Failure, Acute		Acetaminophen	3.54	16871587 17185352
MESH:D008113	Liver Neoplasms		2,6-dinitrotoluene	2.24	7678174
MESH:D008114	Liver Neoplasms, Experimental		2,6-dinitrotoluene	2.72	2876784 6135515 2876786
MESH:D016393	Lymphoma, B-Cell		Sodium Selenite	4.41	14737004
MESH:D008546	Melanoma, Experimental		Acetaminophen	3.98	19513568
MESH:D008664	Metal Metabolism, Inborn Errors		Cyclosporine	5.31	16801185
MESH:D009336	Necrosis		2,6-dinitrotoluene	4.32	18551238 7678174
MESH:D009402	Nephrosis, Lipoid		Cyclosporine	4.96	17954296
MESH:D009404	Nephrotic Syndrome		Cyclosporine	3.57	18481113 19348381
MESH:D019636	Neurodegenerative Diseases		Acetaminophen	3.14	18514411
MESH:D009784	Occupational Diseases		2,6-dinitrotoluene	3.74	16049721
MESH:D010146	Pain		Acetaminophen	2.65	16870215
MESH:D011230	Precancerous Conditions		Cyclosporine	3.51	12371664
MESH:D011471	Prostatic Neoplasms		Sodium Selenite	3.34	18760546
MESH:D011565	Psoriasis		Cyclosporine	2.31	16882103
MESH:D012640	Seizures		2,6-dinitrotoluene	2.74	18551238
MESH:D012878	Skin Neoplasms		tert-Butylhydroperoxide	2.81	8532709
MESH:D001749	Urinary Bladder Neoplasms		2,6-dinitrotoluene	2.39	16049721
MESH:D014571	Urologic Neoplasms		2,6-dinitrotoluene	4.78	10091137
MESH:D014581	Urticaria		Acetaminophen	3.33	10982225
MESH:D014605	Uveitis		Cyclosporine	4.50	1336536
MESH:D014985	Xerophthalmia		Cyclosporine	4.96	17120751

Pathway ID	Pathway Name
KEGG:04144	Endocytosis
REACT:6900	Signaling in Immune system
KEGG:04120	Ubiquitin mediated proteolysis

AutismKB 2.0

Annotation Detail for ITCH

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics