AutismKB 2.0

Annotation Detail for GRWD1


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Basic Information Top
Gene Symbol:GRWD1 ( CDW4,GRWD,KIAA1942,RRB1,WDR28 )
Gene Full Name: glutamate-rich WD repeat containing 1
Band: 19q13.33
Quick LinksEntrez ID:83743; OMIM: 610597; Uniprot ID:GRWD1_HUMAN; ENSEMBL ID: ENSG00000105447; HGNC ID: 21270
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GRWD1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GRWD1 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRWD1 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of GRWD1 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GRWD1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of GRWD1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of GRWD1 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in decreased expression of GRWD1 mRNAdecreases expression 18037150
D012402 Rotenone Rotenone results in decreased expression of GRWD1 mRNAdecreases expression 19013527
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRWD1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GRWD1 mRNAincreases expression 19465110
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of GRWD1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2811752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617157402 18177632 15238991 18940202 17507914 18396377 18558336 17688650 18316065 19460635 20603192 19232924 18985861 16609825 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.1717594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215380490 15845082 15665606
MESH:D001943 Breast Neoplasms Progesterone 2.0315562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.903084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2517110522 11677210 15861022 16105132 17333356 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5216575769 8888407 17688650
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4012153990 12705907 15619225 10663392 19923254 14725611 11529661 10915739 2444490 16781746 19420014 12958197 10774834 16109766 18713872 17522070 11743745 11461765 14550746 16227642 11739529 16081117 12392966 19416960 12540782 11287661 19164858 14986274 16177239 11421492 12594235 19739265 15968718 17906064 17562736 18071297 16485898 11834606 19370779 16393943 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.401733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.8412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.8417692515
MESH:D004715 Endometriosis Progesterone 9.5816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.589294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2915345470
MESH:D005234 Fatty Liver pirinixic acid 14.2920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 14.2914986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3718558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 18606429 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Progesterone 5.3015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3012878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1416705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 11587558 19784758 16610002 12969438 12587719 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.4716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9917203775 11408345
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009410 Nerve Degeneration Rotenone 4.0418619942 15790535 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2516359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6212819281 16049721
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010300 Parkinson Disease Rotenone 3.0411535288 16412576 11445065 18619942 15451049 19232380 19114014 18191903 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.2715927086 18197244 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures Valproic Acid 6.391511512 17978042 11044598 15475178 16876388 11738929 14763951 3137016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.5616503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3516049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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