AutismKB 2.0

Annotation Detail for GRWD1


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Basic Information Top
Gene Symbol:GRWD1 ( CDW4,GRWD,KIAA1942,RRB1,WDR28 )
Gene Full Name: glutamate-rich WD repeat containing 1
Band: 19q13.33
Quick LinksEntrez ID:83743; OMIM: 610597; Uniprot ID:GRWD1_HUMAN; ENSEMBL ID: ENSG00000105447; HGNC ID: 21270
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GRWD1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GRWD1 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRWD1 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of GRWD1 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GRWD1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of GRWD1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of GRWD1 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in decreased expression of GRWD1 mRNAdecreases expression 18037150
D012402 Rotenone Rotenone results in decreased expression of GRWD1 mRNAdecreases expression 19013527
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRWD1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GRWD1 mRNAincreases expression 19465110
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of GRWD1 mRNAaffects cotreatment|increases expression 17183730
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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