AutismKB 2.0

Annotation Detail for TAF3


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Basic Information Top
Gene Symbol:TAF3 ( MGC25063,TAF140,TAFII-140,TAFII140 )
Gene Full Name: TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
Band: 10p14
Quick LinksEntrez ID:83860; OMIM: 606576; Uniprot ID:TAF3_HUMAN; ENSEMBL ID: ENSG00000165632; HGNC ID: 17303
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TAF3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TAF3 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil affects the expression of TAF3 mRNAaffects expression 16584549
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TAF3 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5914514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.8117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6214692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.6217638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D000740 Anemia Fluorouracil 10.2017963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 10.2011748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.1211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.9115885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0215136595 19217205 16110121 18608205 18357371 16557594 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.5316051944
MESH:D002277 Carcinoma Fluorouracil 9.4217121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.4216835633
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1217045692 17971768 16332177 18930000 16799960 17088986
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1818695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5818986760 17066447 16280240 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5818850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.2016105132 17333356 17681005 11677210 17110522 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2515340226 16354765 8697196 15668235 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2915001691 17169374 16510598 17016597 17725105 16340194 18772588 17287894 17172411 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 17454858 17016601 17401013 18949393 16391804 17594712 16331619 18288408 18509181 15289873 16524972 17094418 17695437 14970324 15148649 18802399 18383874 16303861 16282729 20501625 18448328
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 5.5316733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.7712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.479294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5317638652 16337965 16481741 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.2915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.6020067830
MESH:D005910 Glioma Fluorouracil 3.0016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6715162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5412621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.918697196 15340226 16959395 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.4616945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0412200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6916985049
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Fluorouracil 4.9415113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3512151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.4415246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.5315086387
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9818986760 16757204
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D009369 Neoplasms Fluorouracil 2.7918239605 18600527 16928823
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.7216436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7819003803 16929163 16500647 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.2211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3419082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 4.0516919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.4315538739 18286688 16160472 18722050
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.8116709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018567086 17498489 19015929 19084572 16951190 15786421 17522103 17172411 16424979 18396642
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.1511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.4416280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.3316803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 4.0214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
Pathway ID Pathway Name
KEGG:03022 Basal transcription factors
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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