AutismKB 2.0

Annotation Detail for CDCA7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CDCA7 ( FLJ14722,FLJ14736,JPO1,MGC34109 )
Gene Full Name: cell division cycle associated 7
Band: 2q31.1
Quick LinksEntrez ID:83879; OMIM: 609937; Uniprot ID:CDCA7_HUMAN; ENSEMBL ID: ENSG00000144354; HGNC ID: 14628
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200045Validated targets of C-MYC transcriptional activation
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CDCA7 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CDCA7 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CDCA7 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDCA7 mRNAdecreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of CDCA7 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CDCA7 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDCA7 mRNA]decreases reaction|increases expression 17854601
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CDCA7 mRNAaffects expression 17555576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDCA7 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDCA7 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CDCA7 mRNAincreases expression 18301758
D012402 Rotenone Rotenone results in decreased expression of CDCA7 mRNAdecreases expression 19013527
D013629 Tamoxifen Tamoxifen affects the expression of CDCA7 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CDCA7 mRNAdecreases expression 20106945
D014415 Tunicamycin Tunicamycin results in decreased expression of CDCA7 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.836695378
MESH:D000236 Adenoma Diethylnitrosamine 6.8310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.2219052882 16434500 17162532 19061943 17620307 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.2216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.2216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.9320135344 19059307 19189212 16273361 19288272 18855134 19221464 19103187 19115204 11161223 20859285 18351453 19200415 16202921 19084267 19142967 18815881 16818667 19011961 19244106 17893378 19066611 20544844 17440819 21152245 18984771 17261762 19487384 15565566 17049068 15668708 20065188 18629630 20390343 19189210 18997820 19155303 18821012 21138602 19289846 19410462 17242785 20005174 16873071 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.693084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6921507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6919919837 20935162 19539802 19052882 20514400 3581430 10672840 18393292 17173139 19394651 16288022 18785209 18506893 17428255 17055752 19519916 17978847 16807293 17138121 3084413 19171122 20084675 17761372 19701751 16878318 19335982 18788625 18210153 20512989 20214788 18978308 20727157 16681979 21159647 19208518 16698587 16569478 17162532 20007298 16328049 11831363 18056438 19383236 20524982 19418558 10737359 16935385 16502159 19107877 18971187 19822196 18691550 16779866 20432363 18665156 20101231 18494052 16830150 16540662
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6916924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.592727394 21159647 7505956 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6516835633
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8217333356 11677210 15861022 16105132 17110522 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3011739529 16227642 11743745 10915739 18713872 11287661 19420014 14550746 11529661 17906064 19164858 17522070 15619225 14725611 12594235 19739265 10774834 12153990 12392966 12958197 16177239 10663392 16485898 14986274 15968718 11421492 17562736 19416960 19370779 18071297 19085960 12705907 16109766 11834606 2444490 11461765 19923254 16781746 16393943 12540782 16081117
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.3019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1119155303 16202921 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 25.8919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 25.8921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.8915345470
MESH:D005234 Fatty Liver pirinixic acid 25.8920131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 25.8914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Cyclosporine 8.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7316120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 15340226 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Diethylnitrosamine 8.5918785209
MESH:D007249 Inflammation Tamoxifen 8.5919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5912878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6112371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6118625569
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8820032147 18522880 19638242 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008107 Liver Diseases Acetaminophen 3.9919460945 16610002 19014921 11587558 19784758 12587719 12969438 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.509163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.5021137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.5020452335 15885732 12771043 20583210 20137499 19255062 19254457 18978307 15175105 21167192 12112319 20101389 21278145 19642983 19812893 16942905 19690152 20434301 19638242 19090486 19499222 19996281 20405173 19551842 19833225 21071580 21047994 20501860 18644402 19294768 19427195 2862719 18754104 19850985 10737359 18977376 20492335 2422723 19426721 19073162 9163691 20118626 19256749 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 18.5016377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 18.5016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.5016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.208603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.2018079962 19004024 18544905 9362446 19009564 21159647 19539802 17174075 18775883 2563599 16267830 17854601 18164116 18308698 17942915 19126423 18093689 16842330 18253720 19519916 3124819 18282651
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2012151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.7014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7020064080 17053015 18816296 20464547 18569708 20135361 20869020 6695378 18520028
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.7021163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.7018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7019555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6914580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.863581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719200415 19196722 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 3.9618619942 15790535 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010300 Parkinson Disease Rotenone 3.0119232380 16412576 19114014 18619942 11445065 18191903 11535288 15451049 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.1815927086 15574749 15795934 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.2712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.272563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1017292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6310029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.352093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.077505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.138653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved