AutismKB 2.0

Annotation Detail for HDAC10


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Basic Information Top
Gene Symbol:HDAC10 ( DKFZp761B039,HD10,MGC149722 )
Gene Full Name: histone deacetylase 10
Band: 22q13.33
Quick LinksEntrez ID:83933; OMIM: 608544; Uniprot ID:HDA10_HUMAN; ENSEMBL ID: ENSG00000100429; HGNC ID: 18128
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200019Signaling events mediated by HDAC Class II
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HDAC10 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HDAC10 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HDAC10 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HDAC10 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HDAC10 mRNAaffects expression 17562736
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HDAC10 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HDAC10 mRNAaffects cotreatment|affects expression 17602206
C029424 hydrazine hydrazine results in decreased expression of HDAC10 mRNAdecreases expression 15282401
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.103712494
MESH:D000236 Adenoma Diethylnitrosamine 7.106695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2418056438 17620307 17162532 19052882 16434500 19061943
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.2116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.2116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.217296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.213084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.2116830150 19052882 16681979 10672840 18691550 17761372 18056438 16935385 20007298 19919837 18978308 18393292 20101231 19701751 17428255 17173139 17162532 16502159 16698587 18788625 20524982 3581430 19383236 18506893 19107877 19335982 20512989 16328049 20935162 20084675 19822196 16878318 18785209 17138121 19519916 19394651 16540662 20214788 21159647 19171122 16807293 17055752 18494052 16288022 20432363 19539802 11831363 18210153 16779866 17978847 20727157 3084413 16569478 19208518 19418558 20514400 10737359 18665156 18971187
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.8514694615
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.136135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.137505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.1321159647 17174075 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.329022650 19486331
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1011298694 18759878 11906362 8156756 8970840 12868966 2524372 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 16.0921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 16.0918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 16.097440962 8291058 6679447 1440618 18692083 6482804 18289764 18648102 16192314 9653073 9022650 9328219 11289319
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 16.0921346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.0917906064 14550746 10915739 19739265 12958197 19416960 16177239 11461765 16081117 12594235 17522070 17562736 11421492 19923254 14725611 15619225 16781746 12540782 16109766 11743745 18071297 10663392 11834606 11739529 16227642 18713872 19085960 10774834 15968718 2444490 11287661 16393943 14986274 19370779 12705907 19420014 19164858 16485898 12392966 12153990 11529661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.0919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4320387270 21071580
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.6016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.6016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.606582329
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9420032147 19638242 18665156 18407596 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 4.0812587719 19784758 16611625 12969438 11587558 19460945 16610002 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.977678174
MESH:D008113 Liver Neoplasms Clofibric Acid 7.9717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9719294768 19073162 20492335 9163691 19812893 19833225 18648771 19427195 19426721 19996281 18977376 21047994 19499222 15885732 20101389 19255062 15175105 19256749 20137499 16942905 20452335 19850985 18644402 20501860 18754104 20434301 10737359 20118626 19638242 18978307 19254457 21167192 12771043 20583210 19690152 20405173 12112319 21071580 21278145 2422723 19090486 19551842 2862719 19642983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.672876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.67598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.6718164116 19539802 18282651 16267830 18253720 17942915 19004024 19009564 16842330 18775883 3124819 18544905 19126423 18079962 18308698 9362446 17174075 19519916 17854601 2563599 21159647 18093689
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.983581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.983581430 9029167
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 23.5716049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 23.5716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 23.574026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 23.5714694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.736587162 3712494 7505956 6582329 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.737505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.768074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38297
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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