AutismKB 2.0

Annotation Detail for IMMP2L


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Basic Information Top
Gene Symbol:IMMP2L ( IMP2,IMP2-LIKE )
Gene Full Name: IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Band: 7q31.1
Quick LinksEntrez ID:83943; OMIM: 605977; Uniprot ID:IMP2L_HUMAN; ENSEMBL ID: ENSG00000184903; HGNC ID: 14598
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of IMMP2L mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of IMMP2L mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IMMP2L proteinaffects expression 20106945
C103505 AM 251 AM 251 results in increased expression of IMMP2L mRNAincreases expression 16500647
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IMMP2L mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IMMP2L mRNAdecreases expression 20713471
C051890 irinotecan irinotecan analog results in decreased expression of IMMP2L mRNAdecreases expression 18927307
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of IMMP2L mRNAdecreases expression 20713471
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 12.083712494
MESH:D000236 Adenoma Benzo(a)pyrene 12.086695378
MESH:D000236 Adenoma Methylcholanthrene 12.0810545420 6695378
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6011922910
MESH:D001321 Autistic Disorder marker/mechanism 19401682
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3017474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3017474063
MESH:D002277 Carcinoma Methylcholanthrene 4.1910545420
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.737296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7321507988 12619106 12907637
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.547505956
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.5416192471
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D003110 Colonic Neoplasms irinotecan 2.6317287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3616391804 16303861 18259882 17454858 17159606 15273666 18509181
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1511906362 12868966 8970840 8156756 2524372 18759878 14531868 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.941440618 8291058 18289764 11289319 18692083 18648102 6482804 9022650 9328219 16192314 6679447 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9419923254 15968718 19164858 19085960 10663392 11834606 16485898 11287661 15619225 19739265 11529661 16109766 11739529 16081117 12392966 16227642 10774834 19416960 11743745 14986274 19420014 10915739 12540782 16781746 18713872 11461765 12594235 14725611 16393943 12958197 17562736 11421492 14550746 17522070 19370779 16177239 2444490 17906064 12153990 18071297 12705907
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.3414633661 10962813
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 16611625 12969438 12587719 19014921 16610002 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.869163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8621137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.91598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.918603461
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.91598648 1399818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6620464547 20135361 18816296 6695378 20064080 18520028 20869020 17053015 18569708
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.6615390079 17909032 1399818 20512841 16271038 6695378 20970405 10545420 16337739 11893704 9230183 21163286 7750092
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D052016 Mucositis irinotecan 5.4017159606
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.243581430
MESH:D009362 Neoplasm Metastasis irinotecan 6.2418259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009447 Neuroblastoma irinotecan 3.608761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D017599 Neuroectodermal Tumors irinotecan 5.128761367
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010146 Pain Acetaminophen 7.8816870215
MESH:D010146 Pain AM 251 7.8818987195
MESH:D010190 Pancreatic Neoplasms AM 251 3.9216500647
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4810029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6120155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 2.6115723263
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096582329 3712494 6587162 7505956 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.278074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2717053015
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
KEGG:03060 Protein export
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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