AutismKB 2.0

Annotation Detail for PLA2G10


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Basic Information Top
Gene Symbol:PLA2G10 ( GXPLA2,GXSPLA2,MGC119918,MGC119919,MGC133367,SPLA2 )
Gene Full Name: phospholipase A2, group X
Band: 16p13.12
Quick LinksEntrez ID:8399; OMIM: 603603; Uniprot ID:PA2GX_HUMAN; ENSEMBL ID: ENSG00000069764; HGNC ID: 9029
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
LIPASYN-PWYphospholipases
Pathway IDPathway Name
hsa00565Ether lipid metabolism
hsa00564Glycerophospholipid metabolism
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa00590Arachidonic acid metabolism
hsa05145Toxoplasmosis
hsa04730Long-term depression
hsa04972Pancreatic secretion
hsa00592alpha-Linolenic acid metabolism
hsa01100Metabolic pathways
hsa00591Linoleic acid metabolism
hsa04370VEGF signaling pathway
hsa04664Fc epsilon RI signaling pathway
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No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLA2G10 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PLA2G10 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of PLA2G10 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of PLA2G10 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PLA2G10 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PLA2G10 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLA2G10 mRNAaffects cotreatment|increases expression 17942748
D007657 Ketone Bodies Ketone Bodies results in decreased expression of PLA2G10 mRNAdecreases expression 16807920
D011374 Progesterone Progesterone affects the expression of PLA2G10 mRNAaffects expression 17251523
D013629 Tamoxifen Tamoxifen affects the expression of PLA2G10 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLA2G10 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of PLA2G10 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5415885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.5416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5216197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0320146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 3.0311237771
MESH:D001943 Breast Neoplasms Progesterone 3.0317614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tamoxifen 3.0320135344 18984771 19221464 19189210 19103187 17049068 20544844 19011961 18815881 17242785 19155303 16873071 18855134 21152245 19115204 19289846 18351453 19059307 16202921 17261762 18629630 20390343 19142967 19410462 19244106 20065188 15565566 16273361 15668708 19288272 11161223 18997820 17893378 18821012 21138602 16818667 19084267 19189212 20859285 19066611 19200415 17440819 20005174 19487384 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0320435547
MESH:D001943 Breast Neoplasms Tretinoin 3.0316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.101917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.8011237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.8016096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2017333356 17110522 17681005 15861022 16919318 16105132 11677210
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9815340226 16354765 8697196 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4915322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.498800419 9125849 10589399 9142499 17551590 9664655 16925845 9224671 14991402 9211117
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 23.6715138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 23.6712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 23.6717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 23.6719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.8019155303 17893378 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 7.8016569247
MESH:D004715 Endometriosis Progesterone 9.4716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.479294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 9.2616938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 14.0819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.0815345470
MESH:D005234 Fatty Liver Tamoxifen 14.0819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Cyclosporine 16.0312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0320067830
MESH:D005355 Fibrosis Tretinoin 16.0317994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.5714991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Progesterone 8.7815869954
MESH:D007249 Inflammation Tamoxifen 8.7819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7812200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.5115992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4318776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.7818625569
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.269834237 17506722 17107899 16935935 16766008 17368321 16331271 12679006 19035177 16788101 19642359 16140955 17649720 19225113 17361223 19075265 17294898 17301526 17712046 19029980 17339181 16891316 17217047 15748426 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5416248980 18397230
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7021137059 20195826
MESH:D008113 Liver Neoplasms Tamoxifen 7.7016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4320064080 18520028 20135361 20464547 6695378 18816296 20869020 18569708 17053015
MESH:D008175 Lung Neoplasms Tamoxifen 3.4318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4311884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4311408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4311731420 14580682 19196722 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tamoxifen 3.3719393235 12393984
MESH:D008545 Melanoma Tretinoin 3.3716752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2511141357
MESH:D009369 Neoplasms Tretinoin 5.2516594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1814600291
MESH:D009421 Nervous System Malformations Tretinoin 10.189125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D010051 Ovarian Neoplasms Progesterone 5.0716525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0716936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11896295 11222880 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5317292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5312479363 15754350 16289102 18247401 16644109
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5315067354
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8216192470
MESH:D012878 Skin Neoplasms Tretinoin 9.8216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.6815862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.6819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3820155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3817261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1916712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:00592 alpha-Linolenic acid metabolism
KEGG:00590 Arachidonic acid metabolism
KEGG:00565 Ether lipid metabolism
KEGG:04975 Fat digestion and absorption
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04724 Glutamatergic synapse
KEGG:00564 Glycerophospholipid metabolism
KEGG:04912 GnRH signaling pathway
KEGG:00591 Linoleic acid metabolism
KEGG:04730 Long-term depression
KEGG:04010 MAPK signaling pathway
KEGG:01100 Metabolic pathways
KEGG:04972 Pancreatic secretion
KEGG:05145 Toxoplasmosis
KEGG:04270 Vascular smooth muscle contraction
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03684 - 2-Methyl-2,4-Pentanediol
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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