AutismKB 2.0

Annotation Detail for GPR98


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Basic Information Top
Gene Symbol:GPR98 ( DKFZp761P0710,FEB4,KIAA0686,MASS1,USH2B,USH2C,VLGR1,VLGR1b )
Gene Full Name: G protein-coupled receptor 98
Band: 5q13
Quick LinksEntrez ID:84059; OMIM: 602851; Uniprot ID:GPR98_HUMAN; ENSEMBL ID: ENSG00000164199; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
PHARMACOGENOMIC
response to antipsychotic treatment
METABOLIC
hip geometry
Desease Name
Response to antipsychotic treatment
Hip geometry
Desease Name
Convulsions, familial febrile, 4
Usher syndrome, type IIC
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GPR98 mRNAaffects expression 17562736
D002117 Calcitriol Calcitriol results in increased expression of GPR98 mRNAincreases expression 16002434
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GPR98 geneincreases mutagenesis 17329413
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of GPR98 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of GPR98 mRNAdecreases expression 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D000236 Adenoma Ethylnitrosourea 3.926695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.6017620307
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001927 Brain Diseases Ethylnitrosourea 5.2814991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.6816436596 18412241 16357521 16651633 15144691
MESH:D001943 Breast Neoplasms Calcitriol 2.5611237771
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0220007298 1701930 20935162 6705139 17173139
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.7111237771
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.9816003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.7117160924
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6717522070 18713872 17906064 14725611 19416960 10663392 11421492 16781746 16177239 19164858 12958197 11739529 12705907 12540782 10915739 14550746 16227642 19923254 19420014 10774834 19085960 19370779 15968718 17562736 11461765 12594235 16109766 11529661 14986274 16485898 19739265 12392966 11834606 15619225 18071297 2444490 11287661 11743745 16081117 16393943 12153990
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.7118357618
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.4415138306
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.593922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
OMIM:604352 FEBRILE SEIZURES, FAMILIAL, 4 marker/mechanism
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005909 Glioblastoma Ethylnitrosourea 4.0716436596
MESH:D005910 Glioma Ethylnitrosourea 3.6218412241 16651633 16357521
MESH:D006529 Hepatomegaly Phenobarbital 4.0416109766
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.2717379185
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0821047994
MESH:D008107 Liver Diseases Acetaminophen 4.2016611625 12969438 11587558 19014921 12587719 19784758 16610002 19460945
MESH:D008107 Liver Diseases Phenobarbital 4.2019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 2.4219812893 8742319 15975961 19482888 19073162 21047994
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.926150874 17172636 18308698 1399818 2563599
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6317703301 16271038 6695378 16019985
MESH:D008223 Lymphoma Ethylnitrosourea 4.2215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.6115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7418041768 10767621 10838139
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008579 Meningioma Ethylnitrosourea 6.7117943659
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.9616707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.0516003739 17160924 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.7117160924
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.4115572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4816644109 16289102 15754350 12479363 18247401
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D012640 Seizures Phenobarbital 2.954039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.7915790496
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
MESH:D014581 Urticaria Acetaminophen 3.4410982225
OMIM:605472 USHER SYNDROME, TYPE IIC marker/mechanism
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134960779
    • No data
    Releated disease ID Related disease Name
    PA445131Obesity
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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