AutismKB 2.0

Annotation Detail for ULK1


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Basic Information Top
Gene Symbol:ULK1 ( ATG1,ATG1A,FLJ38455,FLJ46475,UNC51,Unc51.1 )
Gene Full Name: unc-51-like kinase 1 (C. elegans)
Band: 12q24.33
Quick LinksEntrez ID:8408; OMIM: 603168; Uniprot ID:ULK1_HUMAN; ENSEMBL ID: ENSG00000177169; HGNC ID: 12558
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04150mTOR signaling pathway
hsa04140Regulation of autophagy
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ULK1 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of ULK1 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of ULK1 mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of ULK1 mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of ULK1 mRNAincreases expression 15757668
C056933 fumonisin B1 fumonisin B1 results in decreased expression of ULK1 mRNAdecreases expression 16221962
C030667 methylazoxymethanol methylazoxymethanol results in increased expression of ULK1 mRNAincreases expression 17107856
C041786 palm oil palm oil results in decreased expression of ULK1 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of ULK1 mRNAdecreases expression 16221962
C006253 pirinixic acid pirinixic acid results in increased expression of ULK1 mRNAincreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Calcitriol 1.9411237771
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D001943 Breast Neoplasms Estradiol 1.9416675129 14630087 19861407 17289903 17261762 12948864 17018787 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.903084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9016924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6711237771
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9118566989
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.2316227642 14725611 15968718 12392966 17522070 12594235 19085960 11529661 16081117 16393943 16177239 19923254 16109766 2444490 12958197 19416960 14986274 11287661 11421492 10915739 19420014 12705907 10774834 18071297 11834606 10663392 15619225 11461765 19739265 16485898 19164858 14550746 16781746 18713872 19370779 17906064 11743745 11739529 12153990 17562736 12540782
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 4.2316221962
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1715138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.1111473722 18566989 19148513
MESH:D005234 Fatty Liver Dietary Fats 8.3919551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver pirinixic acid 8.3919236843 20131406
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly fumonisin B1 9.6416221962
MESH:D006529 Hepatomegaly pirinixic acid 9.6418467677 16221962 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 13.0411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 13.0416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 13.0416306350
MESH:D007674 Kidney Diseases Acetaminophen 6.2515629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.2515618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1515610895
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 12969438 19784758 12587719 16610002 19014921 16611625 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8815890375 16377806 20007298
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6811408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 3.8916427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Dietary Fats 4.5819632207 21332399 18674790 20518802 11836018 17217161 18457598 20132043 16723640
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0615572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2712479363 18247401 16289102 15754350 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 3.2716740699
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
Pathway ID Pathway Name
KEGG:04150 mTOR signaling pathway
KEGG:04140 Regulation of autophagy
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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