AutismKB 2.0

Annotation Detail for FBXO30


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FBXO30 ( FLJ41030,Fbx30,MGC21674 )
Gene Full Name: F-box protein 30
Band: 6q24.3
Quick LinksEntrez ID:84085; OMIM: 609101; Uniprot ID:FBX30_HUMAN; ENSEMBL ID: ENSG00000118496; HGNC ID: 15600
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FBXO30 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of FBXO30 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FBXO30 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FBXO30 mRNAdecreases expression 19150397
20382639
D016572 Cyclosporine Cyclosporine results in increased expression of FBXO30 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of FBXO30 mRNAdecreases expression 18503570
C006253 pirinixic acid pirinixic acid results in increased expression of FBXO30 mRNAincreases expression 18301758
C006253 pirinixic acid pirinixic acid results in increased expression of FBXO30 mRNAincreases expression 12832660
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0817474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.0820435547
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.923084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1712371664
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9418713872 12958197 17562736 17522070 12594235 17906064 11743745 18071297 15619225 16177239 19420014 11287661 12153990 19085960 10663392 15968718 11529661 10915739 2444490 16081117 16393943 12705907 16485898 16109766 12540782 11421492 14986274 19739265 19923254 16781746 16227642 11461765 12392966 14725611 19164858 19416960 19370779 10774834 11739529 14550746 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005234 Fatty Liver Cyclosporine 14.7619224547
MESH:D005234 Fatty Liver Dietary Fats 14.7617967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 14.7619236843 20131406
MESH:D005355 Fibrosis Cyclosporine 9.9212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.9218296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 19772884 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007333 Insulin Resistance Dietary Fats 7.8211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.8216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.2810903974 8314463 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6816611625 19784758 16610002 12969438 12587719 19460945 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6620195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.6616377806 15890375 20007298
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 20064080 18569708 20135361 18816296 6695378 17053015 18520028 20869020
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2211141357
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Dietary Fats 4.6218674790 21332399 20132043 18457598 11836018 17217161 19632207 16723640 20518802
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6912819281 16049721
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2817053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved