AutismKB 2.0

Annotation Detail for UXT


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Basic Information Top
Gene Symbol:UXT ( ART-27,STAP1 )
Gene Full Name: ubiquitously-expressed transcript
Band: Xp11.23
Quick LinksEntrez ID:8409; OMIM: 300234; Uniprot ID:UXT_HUMAN; ENSEMBL ID: ENSG00000126756; HGNC ID: 12641
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200027E2F transcription factor network
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of UXT mRNAdecreases expression 12958071
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of UXT mRNAaffects expression 18648102
C053541 bicalutamide UXT protein affects the susceptibility to bicalutamideaffects response to substance 19318562
C099555 CD 437 CD 437 results in decreased expression of UXT mRNAdecreases expression 12958071
D005472 Fluorouracil Fluorouracil results in increased expression of UXT proteinincreases expression 15585135
16803524
D015741 Metribolone Metribolone promotes the reaction [UXT protein binds to ATR promoter]affects binding|increases reaction 19318562
D015741 Metribolone Metribolone promotes the reaction [UXT protein binds to GSTE1 promoter]affects binding|increases reaction 19318562
D015741 Metribolone Metribolone promotes the reaction [UXT protein binds to KLK3 promoter]affects binding|increases reaction 19318562
D015741 Metribolone Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter]affects binding|increases reaction 19318562
D015741 Metribolone UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA]affects reaction|increases expression 19318562
D015741 Metribolone UXT protein affects the reaction [Metribolone results in increased expression of KLK3 mRNA]affects reaction|increases expression 19318562
D015741 Metribolone UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]affects reaction|increases expression 19318562
D015741 Metribolone UXT protein affects the susceptibility to Metriboloneaffects response to substance 19318562
D018038 Sodium Selenite Sodium Selenite results in increased expression of UXT mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D000740 Anemia Fluorouracil 3.9816511603 17963324 15504547
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001943 Breast Neoplasms Fluorouracil 2.4416595493 18608205 16557594 18357371 19217205 16110121 15136595
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1116051944
MESH:D002277 Carcinoma Fluorouracil 3.7917121937
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.183581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.1817971768 18930000 16332177 17088986 16799960 17045692
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.877296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.8718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5518986760 17066447 16280240 16757204
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.947505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3519486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717016597 16510598 17018589 15001691 17169374 17725105 17172411 18772588 16340194 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015289873 20501625 18949393 18802399 17255274 16303861 17094418 17695437 17016601 16524972 18288408 18383874 14970324 18509181 17594712 16331619 18448328 15148649 16391804 17401013 16282729 17454858
MESH:D007644 Darier Disease Fluorouracil 5.1916733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1511298694 12868966 2524372 11906362 14531868 8156756 18759878 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.199022650 9328219 6482804 18692083 11289319 16192314 9653073 7440962 18289764 8291058 18648102 1440618 6679447
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.1915131321
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.723581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7216785472 16337965 17638652 15173087 16481741
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005910 Glioma Fluorouracil 2.9616145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5618337622 15102660 15162350
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007333 Insulin Resistance Sodium Selenite 3.4514714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.276582329
MESH:D007680 Kidney Neoplasms Fluorouracil 8.2716985049
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008113 Liver Neoplasms Fluorouracil 2.5616603448 15113037 18383874 17045692
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.693712494 6587162 1399818 598648
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1915086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8418986760 16757204
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Fluorouracil 2.7218239605 18600527 16928823
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6116436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010051 Ovarian Neoplasms CD 437 3.3817474084
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7416929163 15113037 19003803 16500647
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011471 Prostatic Neoplasms marker/mechanism 19318562
MESH:D011471 Prostatic Neoplasms bicalutamide 2.7119011039 18487222 19240160 15638997 17914592
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7119082440 18626508
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7118760546
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2618286688 15538739 16160472 18722050
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 17498489 18567086 15786421 17522103 17172411 16951190 19084572 19015929 16424979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096587162 6582329 7505956 1399818 3712494
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2516280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.728074119
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.7216720286
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1416803524
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37265
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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