AutismKB 2.0

Annotation Detail for SLC41A2


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Basic Information Top
Gene Symbol:SLC41A2 ( DKFZp434K0427,MGC125330,MGC125331,SLC41A1-L1 )
Gene Full Name: solute carrier family 41, member 2
Band: 12q23.3
Quick LinksEntrez ID:84102; OMIM: 610802; Uniprot ID:S41A2_HUMAN; ENSEMBL ID: ENSG00000136052; HGNC ID: 31045
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC41A2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC41A2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of SLC41A2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SLC41A2 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC41A2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of SLC41A2 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of SLC41A2 mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of SLC41A2 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of SLC41A2 mRNAdecreases expression 19270015
19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC41A2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SLC41A2 mRNAincreases expression 17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC41A2 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 15.447525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 15.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.4415322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.4717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516227642 16192424 15721981 3786805 16124888 10355542 18705752 16050911 15673190 16011737 15700767 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.083084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0818788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.0817173139 20007298 6705139 20935162 1701930
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 16120746 18670907
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.6814694615
MESH:D002386 Cataract Acetaminophen 7.6810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.896135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8912371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 12621046 15668235 8697196 15340226
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.6115095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.6117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.7818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.7821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7812153990 12392966 18071297 10774834 11739529 15968718 14550746 12705907 10915739 2444490 12594235 16109766 11743745 12958197 19420014 19739265 17906064 19416960 12540782 16081117 19164858 11421492 10663392 19085960 11287661 14725611 11529661 17522070 18713872 16781746 11461765 17562736 11834606 16227642 16177239 16393943 16485898 19923254 15619225 14986274 19370779
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.787120509 19085960 7179309 4309450 15027814 16177239 6623471 9327722 7440962 15968718 19336974 10915739 3786805 2869522 11566570 10092053 3732212 17522070 15998439 6884620 16227642 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.9612631006 17595544 19224547 16239168 16045604 15959796 12795759 61145
MESH:D005234 Fatty Liver Cyclosporine 19.9619224547
MESH:D005234 Fatty Liver Dietary Fats 19.9617967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 19.9620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 22.6918705752
MESH:D005355 Fibrosis Cyclosporine 22.6912168785 12639820
MESH:D005355 Fibrosis Dietary Fats 22.6918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.6920067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 15.4416109766
MESH:D006529 Hepatomegaly pirinixic acid 15.4419772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.4415340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007249 Inflammation Dietary Fats 5.1420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.5418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.0518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.0616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0612371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.4517334410 16943688 16221502 17157831 21278145 11408273 16239168 17174718 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 11.4518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 11.4521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4615996030 15650968 15362042 14620537 12546737 14716496 17481882 15370692 15818738 15931870 14748882 12666154 16248980 18006644 17557913 12958196 17805973 17631135 18251166 16116963 18412020 16192424 12632514 12445421 16027843 12632512 15338365 20821823 18395914 15052691 17714472 16033810 16136751 18054572 17761835 15876570 18429990 14512876 12741479 16638106 18472332 15925388 18376398 13678700 18472094 18418968 15673190 18187930 17869086 17944888 12898905 15893842 12586293 11481614 12649538 17525996 17708605 12667390 10355542 17823541 18277467 16097048 15123356 18166357 15730626 17922224 18210741 18395095 18339082 12609069 18156304 12389079 17698563 14724832 18420326 16011737 16015684 18317297 17766677 18705752 17976157 18481824 15959796 15057751 17640975 17565644 17721639 14716833 18263696 18205269 12445418 18279442 17900296
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 6.6711587558 12969438 19784758 19460945 12587719 19014921 16610002 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6715830285 16246199 15720792 17285989 16964402
MESH:D008107 Liver Diseases Phenobarbital 6.6719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.757678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.7519294768
MESH:D008113 Liver Neoplasms Phenobarbital 14.7519482888 21047994 15975961 8742319 19073162 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 14.7516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.812876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.8115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.8118308698 17172636 1399818 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.007678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity Dietary Fats 4.5421332399 11836018 18674790 20518802 20132043 17217161 16723640 18457598 19632207
MESH:D009765 Obesity pirinixic acid 4.5420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.9416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.9416049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.9414694615
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.3912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.392563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11118676 11399792 11896295
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3618551238
MESH:D012640 Seizures Phenobarbital 10.363137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.161399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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