AutismKB 2.0

Annotation Detail for PRAM1


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Basic Information Top
Gene Symbol:PRAM1 ( MGC39864,PML-RAR,PRAM-1 )
Gene Full Name: PML-RARA regulated adaptor molecule 1
Band: 19p13.2
Quick LinksEntrez ID:84106; OMIM: 606466; Uniprot ID:PRAM_HUMAN; ENSEMBL ID: ENSG00000133246; HGNC ID: 30091
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in increased expression of PRAM1 mRNAincreases expression 16982809
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [PRAM1 protein results in decreased expression of MIR210 mRNA]decreases expression|decreases reaction 18941112
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [PRAM1 protein results in decreased expression of MIR23A mRNA]decreases expression|decreases reaction 18941112
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [PRAM1 protein results in decreased expression of RARB mRNA]decreases expression|decreases reaction 18941112
C027185 indirubin [tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 proteinaffects cotreatment|increases degradation|increases ubiquitination 18344322
C089730 rosiglitazone rosiglitazone results in increased expression of PRAM1 mRNAincreases expression 16982809
C021751 tanshinone [tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 proteinaffects cotreatment|increases degradation|increases ubiquitination 18344322
C534735 tetraarsenic tetrasulfide [tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 proteinaffects cotreatment|increases degradation|increases ubiquitination 18344322
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide results in increased ubiquitination of and results in increased degradation of PRAM1 proteinincreases degradation|increases ubiquitination 18344322
D014212 Tretinoin Tretinoin inhibits the reaction [PRAM1 protein results in decreased expression of MIR23A mRNA]decreases expression|decreases reaction 18941112
D014212 Tretinoin Tretinoin results in increased expression of PRAM1 mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3411798837 19825857
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.9019621015
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.1316206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.1316197459 16206674
MESH:D001943 Breast Neoplasms tanshinone 2.6615849732 19885617
MESH:D001943 Breast Neoplasms Tretinoin 2.6616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1815553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.181917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516051514 16096774
MESH:D002386 Cataract Am 580 8.3717460283
MESH:D002386 Cataract Tretinoin 8.3717460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Am 580 11.1517035595
MESH:D003092 Colitis Tretinoin 11.1517035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7410525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7414991402 10589399 9224671 17551590 9142499 16925845 9211117 9664655 9125849 8800419
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003920 Diabetes Mellitus rosiglitazone 4.5517446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9912642470
MESH:D004487 Edema rosiglitazone 3.9212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tretinoin 3.7816938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 9.1015073043
MESH:D005234 Fatty Liver rosiglitazone 9.1019196556
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D005910 Glioma tanshinone 4.1216955220
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0214991402 9664655
MESH:D006930 Hyperalgesia rosiglitazone 8.8212083418
MESH:D006930 Hyperalgesia Tretinoin 8.8216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006968 Hypersensitivity, Delayed indirubin 6.3811275354
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.5019662366
MESH:D007249 Inflammation rosiglitazone 3.2512083418
MESH:D007333 Insulin Resistance rosiglitazone 3.9716306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D007938 Leukemia arsenic trioxide 6.7515070760
MESH:D007938 Leukemia Tretinoin 6.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 9.6514633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 9.6519208803
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.4319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.4316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0217050201 16467208 20471514 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0219850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2016112521 17217047 19642359 15622746 12712474 17869043 15748426 16966277 19035177 17649720 16330433 12679006 16331271 11161223 17107899 19225113 9834237 16823087 15213294 12018890 19075265 15336539 11468182 17712046 16891316
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2016331271 16140955 16766008 19035177 19225113 17217047 15748426 16823087 17649720 17294898 16935935 16891316 12679006 17107899 17506722 17339181 16788101 17712046 17368321 17361223 17301526 19075265 19029980 19642359 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.8417347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.8418397230 16248980
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4214682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8920377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.5516827153
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.6117261469
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919549372 19417148 14977855 11468182 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8716105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8717596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms Tretinoin 2.5216594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.119125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8710525206
MESH:D009436 Neural Tube Defects Tretinoin 7.879142499
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1119769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1116936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5715580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5715976015
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5117007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.5117261132
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9219014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.9217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5720435036 12973940 11780464 12845720
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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