AutismKB 2.0

Annotation Detail for BCAR3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BCAR3 ( KIAA0554,NSP2,SH2D3B )
Gene Full Name: breast cancer anti-estrogen resistance 3
Band: 1p22.1
Quick LinksEntrez ID:8412; OMIM: 604704; Uniprot ID:BCAR3_HUMAN; ENSEMBL ID: ENSG00000137936; HGNC ID: 973
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200059Regulation of CDC42 activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of BCAR3 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BCAR3 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of BCAR3 mRNAdecreases expression 18648102
C016601 4-hydroxytamoxifen BCAR3 protein results in decreased susceptibility to 4-hydroxytamoxifendecreases response to substance 18351453
D000082 Acetaminophen Acetaminophen affects the expression of BCAR3 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of BCAR3 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of BCAR3 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BCAR3 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of BCAR3 mRNA]decreases expression|decreases reaction 19228888
D016572 Cyclosporine Cyclosporine results in increased expression of BCAR3 mRNAincreases expression 20106945
D005472 Fluorouracil BCAR3 protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D005472 Fluorouracil Fluorouracil results in decreased expression of BCAR3 proteindecreases expression 15352031
D010126 Ozone Ozone results in increased expression of BCAR3 mRNAincreases expression 17095637
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of BCAR3 mRNA]decreases expression|decreases reaction 19228888
D014284 Triiodothyronine Triiodothyronine results in decreased expression of BCAR3 mRNAdecreases expression 19228888
D013629 Tamoxifen BCAR3 protein affects the susceptibility to Tamoxifenaffects response to substance 19075277
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BCAR3 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000230 Adenocarcinoma Fluorouracil 2.4417638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000740 Anemia Fluorouracil 8.8517963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.8511748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6517854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D001943 Breast Neoplasms marker/mechanism 19075277
MESH:D001943 Breast Neoplasms bisphenol A 1.9617123778
MESH:D001943 Breast Neoplasms Fluorouracil 1.9615136595 16595493 19217205 16557594 18357371 18608205 16110121
MESH:D001943 Breast Neoplasms Tamoxifen 1.9618855134 19200415 17242785 19155303 20135344 18629630 16202921 19011961 19142967 19189212 18425577 15565566 18351453 20859285 20005174 21152245 18984771 17893378 19289846 19189210 21138602 17261762 20065188 19115204 17049068 15668708 19059307 11161223 19487384 19084267 19103187 18815881 17440819 19221464 19066611 20390343 16818667 19288272 19244106 20544844 16273361 16873071 19410462 18997820 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7215516495 16777450 18315731 19059883 14754758 18417511 17626835
MESH:D002100 Cachexia Ozone 4.8216183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Fluorouracil 8.3317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5819066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.967296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.963084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.9617088986 17971768 16332177 16799960 17045692 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.9616924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.577296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.5718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5017066447 16280240 18986760 16757204
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.357505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3512371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.0119486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.0119486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 8697196 15340226 15668235 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2418772588 17287894 15001691 16340194 16510598 17016597 17725105 17172411 17018589 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018383874 18802399 17094418 17255274 18288408 16524972 18949393 16391804 17454858 20501625 15148649 14970324 16303861 18448328 17594712 17695437 15289873 16331619 18509181 17401013 17016601 16282729
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0918551238
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4319031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8718759878 14531868 12868966 11906362 8156756 2524372 11298694 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.0718692083 16192314 18289764 8291058 9653073 9022650 6482804 1440618 11289319 6679447 18648102 9328219 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0716177239 16781746 16109766 12705907 11421492 19416960 15968718 10663392 19085960 14986274 15619225 10915739 12392966 11287661 17522070 12958197 10774834 12540782 16081117 11529661 16485898 19739265 19164858 14550746 17562736 17906064 19420014 14725611 18713872 12153990 2444490 16227642 19923254 11461765 11743745 11834606 11739529 18071297 16393943 19370779 12594235
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.6019031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.9219148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.9216202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.323581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3220426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.3216337965 15173087 17638652 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 7.8919224547
MESH:D005234 Fatty Liver Tamoxifen 7.8914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2619069698
MESH:D005355 Fibrosis Cyclosporine 8.7212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005910 Glioma Fluorouracil 2.8916145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4218337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3611294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007249 Inflammation Tamoxifen 4.9819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 3.3216393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.129022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.8910903974 18776723 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.8516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 23.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 23.8512371664
MESH:D007680 Kidney Neoplasms Fluorouracil 23.8516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 23.8518625569
MESH:D008064 Lipidoses Tamoxifen 3.1917567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6416610002 19014921 16611625 19460945 12587719 12969438 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 7.5417045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Tamoxifen 7.5416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.841399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8412151625
MESH:D008171 Lung Diseases Ozone 3.4119066396 8266340
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.4917365036
MESH:D055370 Lung Injury Ozone 9.4920417186
MESH:D008175 Lung Neoplasms Fluorouracil 4.9015246190
MESH:D008175 Lung Neoplasms Ozone 4.907614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 4.9018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6614580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6419453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2018303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008679 Metaplasia Ozone 5.2010496685
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6716757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.763581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5319410462
MESH:D009369 Neoplasms Fluorouracil 2.6318239605 18600527 16928823
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1019189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 9.8016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4716436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0516049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.056482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6816929163 19003803 16500647 15113037
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010538 Peritonitis Ozone 4.2016369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9610923243
MESH:D011014 Pneumonia Ozone 4.4818929643 18381685 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.7910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7911399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2620887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6019082440 18626508
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6015067354
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0517975199 17322281 17365031 15814490
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0618286688 18722050 16160472 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5718551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013088 Spermatocele Tamoxifen 4.3916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1219457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 18567086 17498489 16951190 17172411 19015929 16424979 19084572 15786421 17522103
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.921399818 6582329 3712494 6587162 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0416280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.408074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.408653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9316803524
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved