AutismKB 2.0

Annotation Detail for WDR75


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:WDR75 ( DKFZp781N1244,FLJ12519,NET16 )
Gene Full Name: WD repeat domain 75
Band: 2q32.2
Quick LinksEntrez ID:84128; OMIM: NA; Uniprot ID:WDR75_HUMAN; ENSEMBL ID: ENSG00000115368; HGNC ID: 25725
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of WDR75 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of WDR75 mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of WDR75 mRNAaffects expression 17562736
C017947 sodium arsenite sodium arsenite affects the expression of WDR75 mRNAaffects expression 19590694
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of WDR75 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3814514962 11752688 15322242
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5116712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.923084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.9216507464 15276417 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.536135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.5319524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2216354765 15340226 8697196 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.5618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.5618551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.6621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.6621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.6616227642 12153990 16177239 10915739 17562736 14725611 19370779 16781746 16485898 12705907 11529661 11461765 12392966 17906064 2444490 19416960 16109766 19739265 12594235 11287661 19164858 18713872 14986274 18071297 17522070 12540782 11739529 12958197 19085960 19923254 15968718 14550746 16081117 19420014 16393943 11834606 15619225 10663392 11421492 11743745 10774834
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.6620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 8697196 18606429 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 3.2115346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases Acetaminophen 6.5815629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.5820008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.3916705839
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6912587719 16611625 16610002 12969438 19460945 11587558 19014921 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.057678174
MESH:D008113 Liver Neoplasms sodium arsenite 8.0516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.426135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4212151625
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3817306315 17077188 16712894 19931552 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3811884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0719082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.2118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.2118551238 7678174
MESH:D009369 Neoplasms sodium arsenite 2.6411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3612854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.0616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.0616049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5215276417 17306315
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6518551238
MESH:D012878 Skin Neoplasms sodium arsenite 6.0718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0716192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9916049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.9916712894 16452187 11723127 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.8610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved