AutismKB 2.0

Annotation Detail for ACAD11


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Basic Information Top
Gene Symbol:ACAD11 ( ACAD-11,FLJ12592,MGC150619 )
Gene Full Name: acyl-CoA dehydrogenase family, member 11
Band: 3q22.1
Quick LinksEntrez ID:84129; OMIM: NA; Uniprot ID:ACD11_HUMAN; ENSEMBL ID: ENSG00000113971,ENSG00000240303; HGNC ID: 30211
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ACAD11 mRNAdecreases expression 20406850
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ACAD11 mRNAincreases expression 16788091
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ACAD11 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ACAD11 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ACAD11 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ACAD11 mRNAdecreases expression 20106945
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACAD11 mRNAincreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACAD11 mRNA]increases expression|increases reaction 18467677
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ACAD11 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ACAD11 mRNAincreases expression 18301758
17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0117474063 20146248
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816192424 15700767 15673190 18705752 16227642 15721981 16050911 10355542 16097048 16124888 16011737 3786805
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7716705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7712619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7718788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.116135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.087179309 19085960 10915739 7440962 15027814 16227642 2869522 17522070 6884620 6623471 10092053 15968718 9327722 15998439 21278145 4309450 19336974 16177239 3786805 11566570 7120509 3732212
MESH:D004487 Edema perfluorooctanoic acid 7.7912083418 17259670
MESH:D004487 Edema pirinixic acid 7.7912083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.5016045604 15959796 16239168 19224547 17595544 12795759 12631006 61145
MESH:D005234 Fatty Liver Cyclosporine 14.5019224547
MESH:D005234 Fatty Liver pirinixic acid 14.5019236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 9.7118705752
MESH:D005355 Fibrosis Cyclosporine 9.7112168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.743609246
MESH:D006529 Hepatomegaly pirinixic acid 9.7419176532 18467677 16221962 19772884
MESH:D006930 Hyperalgesia perfluorooctanoic acid 4.0412083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation perfluorooctanoic acid 3.1712083418
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.578812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216943688 16221502 11903743 17174718 17334410 16239168 11408273 17157831 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3817698563 15338365 18412020 12586293 12389079 16248980 12898905 12632514 14620537 18205269 18006644 15876570 15925388 18210741 14716496 12958196 18251166 17721639 12666154 12667390 17823541 18418968 18376398 18156304 14512876 18279442 15370692 16027843 17869086 17640975 18472332 15730626 17708605 12741479 17714472 10355542 12445418 18429990 16015684 12445421 18395914 17525996 15818738 15996030 17557913 17805973 17761835 15673190 12546737 13678700 18054572 18472094 17944888 18277467 17631135 11481614 20821823 18395095 14724832 18187930 18420326 14748882 17766677 17565644 12649538 18166357 15057751 17481882 15931870 16192424 15362042 16116963 18317297 18339082 12609069 15959796 18263696 15052691 17922224 16097048 16136751 16638106 17900296 18481824 17976157 15893842 15650968 16033810 18705752 16011737 12632512 14716833 15123356
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1315830285 16964402 15720792 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.047678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.042125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.0421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 19.0419294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 19.0418709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 19.0415890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.702876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.708603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.7012014681 15583823
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.476695378 18520028 18569708 17053015 20869020 20464547 18816296 20064080 20135361
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.269802331
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.7317132714
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4619755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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