AutismKB 2.0

Annotation Detail for MYST1


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Basic Information Top
Gene Symbol:MYST1 ( FLJ14040,KAT8,MOF,hMOF )
Gene Full Name: MYST histone acetyltransferase 1
Band: 16p11.2
Quick LinksEntrez ID:84148; OMIM: 609912; Uniprot ID:MYST1_HUMAN; ENSEMBL ID: ENSG00000103510; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200175p53 pathway
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MYST1 mRNAaffects expression 17562736
C406082 monomethylarsonous acid MYST1 protein affects the susceptibility to monomethylarsonous acidaffects response to substance 19732783
C006253 pirinixic acid pirinixic acid results in increased expression of MYST1 mRNAincreases expression 18301758
C017947 sodium arsenite MYST1 protein affects the susceptibility to sodium arseniteaffects response to substance 19732783
D015032 Zinc Zinc results in increased expression of MYST1 mRNAincreases expression 15226459
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of MYST1 mRNAincreases expression 15226459
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Zinc Sulfate 5.377265320
MESH:D000169 Acrodermatitis Zinc 5.8717202136 16889938 17190629
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4216712894 17306315
MESH:D000544 Alzheimer Disease Zinc 2.8116325427 16410023 17119284 16580781
MESH:D000755 Anemia, Sickle Cell Zinc 5.2816916123
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D000860 Anoxia Zinc Sulfate 5.487265320
MESH:D001249 Asthma Zinc 3.0317085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001930 Brain Injuries Zinc 5.1117109824
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.0217306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.1618572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.1616543248
MESH:D002318 Cardiovascular Diseases Zinc 3.8716936243
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 7.8719716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.8719524636 20056578
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003920 Diabetes Mellitus Zinc 4.4916479319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6512540782 12958197 14550746 17906064 16485898 19416960 10915739 16177239 12392966 11461765 19923254 17522070 17562736 19420014 15619225 19085960 12153990 15968718 18071297 14986274 18713872 19739265 10774834 16781746 11529661 12594235 10663392 16081117 11743745 14725611 2444490 11834606 19370779 11421492 11739529 16109766 16393943 16227642 19164858 12705907 11287661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004938 Esophageal Neoplasms Zinc 2.9216543248
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005756 Gastritis Acetaminophen 12.9716983495
MESH:D005756 Gastritis Zinc 12.9717241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006130 Growth Disorders Zinc 4.1517217573
MESH:D006333 Heart Failure pirinixic acid 7.7520558911
MESH:D006333 Heart Failure Zinc 7.7517162251
MESH:D006335 Heart Injuries Zinc 6.2917074742
MESH:D016481 Helicobacter Infections Zinc 4.8817241300
MESH:D006527 Hepatolenticular Degeneration Zinc 12.7517276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 12.7517063115
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 16221962 19772884 18467677
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007022 Hypotension Zinc Sulfate 4.827265320
MESH:D007248 Infertility, Male sodium arsenite 3.1912646999 15346721
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007511 Ischemia Zinc 5.0516584753
MESH:D007674 Kidney Diseases Acetaminophen 11.1112587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 11.1120008137
MESH:D007674 Kidney Diseases Zinc 11.1116960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.7516518626
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.5315237267
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6912587719 19784758 16610002 19014921 16611625 12969438 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.8220007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 4.8216712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.3719095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.9016712894 17306315 15276417 17077188 19931552
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.4812773700
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 5.4017405874
MESH:D009369 Neoplasms sodium arsenite 5.4011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5115276417 17306315
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011225 Pre-Eclampsia Zinc 4.4217114810
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.4316039940
MESH:D011471 Prostatic Neoplasms Zinc 3.4316700911 12429649 16517595 16606632
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012162 Retinal Degeneration Zinc 4.3616584753
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4417431481
MESH:D012878 Skin Neoplasms sodium arsenite 2.8219524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D014062 Tongue Neoplasms Zinc 4.7016543248
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 5.8620375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.8617306315 16452187 16712894 11723127
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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