AutismKB 2.0

Annotation Detail for PPP1R1B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PPP1R1B ( DARPP-32,DARPP32,FLJ20940 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 1B
Band: 17q12
Quick LinksEntrez ID:84152; OMIM: 604399; Uniprot ID:PPR1B_HUMAN; ENSEMBL ID: ENSG00000131771; HGNC ID: 9287
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Opioid Signalling
No data
No data
Pathway IDPathway Name
500841DARPP-32 events
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
alcohol consumption
nicotine smoking behavior
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
C087141 2-(1-(4-piperonyl)piperazinyl)benzothiazole 2-(1-(4-piperonyl)piperazinyl)benzothiazole results in decreased phosphorylation of PPP1R1B proteindecreases phosphorylation 11880652
C087141 2-(1-(4-piperonyl)piperazinyl)benzothiazole 2-(1-(4-piperonyl)piperazinyl)benzothiazole results in increased phosphorylation of PPP1R1B proteinincreases phosphorylation 11880652
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]decreases reaction|increases expression 17209049
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
C406233 2-ethyl-5-methoxy-N,N-dimethyltryptamine 2-ethyl-5-methoxy-N,N-dimethyltryptamine results in decreased phosphorylation of PPP1R1B proteindecreases phosphorylation 11880652
C406233 2-ethyl-5-methoxy-N,N-dimethyltryptamine 2-ethyl-5-methoxy-N,N-dimethyltryptamine results in increased phosphorylation of PPP1R1B proteinincreases phosphorylation 11880652
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased phosphorylation of PPP1R1B proteinaffects binding|increases activity|increases phosphorylation 17953657
C015952 4-iodo-2,5-dimethoxyphenylisopropylamine 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of PPP1R1B proteinincreases phosphorylation 11880652
D000082 Acetaminophen Acetaminophen affects the expression of PPP1R1B mRNAaffects expression 17562736
C075631 anpirtoline anpirtoline results in decreased phosphorylation of PPP1R1B proteindecreases phosphorylation 11880652
D002087 Butyrates PPP1R1B protein alternative form results in decreased susceptibility to Butyratesdecreases response to substance 16061638
D002087 Butyrates PPP1R1B protein results in decreased susceptibility to Butyratesdecreases response to substance 16061638
D002166 Camptothecin PPP1R1B protein alternative form results in decreased susceptibility to Camptothecindecreases response to substance 16061638
D002166 Camptothecin PPP1R1B protein results in decreased susceptibility to Camptothecindecreases response to substance 16061638
D002518 Ceramides PPP1R1B protein alternative form results in decreased susceptibility to Ceramidesdecreases response to substance 16061638
D002518 Ceramides PPP1R1B protein results in decreased susceptibility to Ceramidesdecreases response to substance 16061638
D010133 p-Chloroamphetamine PPP1R1B protein affects the reaction [p-Chloroamphetamine results in increased expression of FOS mRNA]affects reaction|increases expression 11880652
D003024 Clozapine Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]decreases phosphorylation|decreases reaction 11880652
D003024 Clozapine Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
D003024 Clozapine Clozapine results in increased phosphorylation of PPP1R1B proteinincreases phosphorylation 12871586
C107676 deguelin deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
D002945 Cisplatin PPP1R1B protein results in increased susceptibility to Cisplatinincreases response to substance 17470401
D004317 Doxorubicin PPP1R1B protein results in decreased export of Doxorubicindecreases export 17470401
D004317 Doxorubicin PPP1R1B protein results in increased susceptibility to Doxorubicinincreases response to substance 17470401
D004958 Estradiol Estradiol results in increased expression of PPP1R1B mRNAincreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPP1R1B mRNAincreases expression 17942748
C045989 eticlopride eticlopride results in increased phosphorylation of PPP1R1B proteinincreases phosphorylation 12871586
D005472 Fluorouracil PPP1R1B protein results in increased susceptibility to Fluorouracilincreases response to substance 17470401
D006220 Haloperidol Haloperidol results in increased phosphorylation of PPP1R1B proteinincreases phosphorylation 12871586
D012701 Serotonin 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
D012701 Serotonin Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]decreases phosphorylation|decreases reaction 11880652
D012701 Serotonin Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
D012701 Serotonin HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]affects phosphorylation|affects reaction 11880652
D012701 Serotonin HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]affects phosphorylation|affects reaction 11880652
D012701 Serotonin HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]affects phosphorylation|affects reaction 11880652
D012701 Serotonin Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
D012701 Serotonin Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]affects reaction|decreases phosphorylation 11880652
D012701 Serotonin Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]affects reaction|increases phosphorylation 11880652
D012701 Serotonin Ro 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]decreases phosphorylation|decreases reaction 11880652
D012701 Serotonin Ro 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
D012701 Serotonin SDZ 205-557 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]decreases phosphorylation|decreases reaction 11880652
D012701 Serotonin SDZ 205-557 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
D012701 Serotonin Serotonin results in decreased phosphorylation of PPP1R1B proteindecreases phosphorylation 11880652
D012701 Serotonin Serotonin results in increased phosphorylation of PPP1R1B proteinincreases phosphorylation 11880652
D012701 Serotonin SK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]decreases phosphorylation|increases reaction 11880652
D012701 Serotonin SK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]increases phosphorylation|increases reaction 11880652
D007650 Ketanserin Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
D008735 5-Methoxytryptamine 5-Methoxytryptamine results in decreased phosphorylation of PPP1R1B proteindecreases phosphorylation 11880652
D008735 5-Methoxytryptamine 5-Methoxytryptamine results in increased phosphorylation of PPP1R1B proteinincreases phosphorylation 11880652
C006253 pirinixic acid pirinixic acid results in decreased expression of PPP1R1B mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in decreased expression of PPP1R1B mRNAdecreases expression 16966611
D019257 Quinpirole Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]affects reaction|decreases phosphorylation 11880652
D019257 Quinpirole Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]affects reaction|increases phosphorylation 11880652
C114163 Ro 4-6790 Ro 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]decreases phosphorylation|decreases reaction 11880652
C114163 Ro 4-6790 Ro 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
C104586 roscovitine roscovitine inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]decreases reaction|increases expression 17209049
C104586 roscovitine roscovitine inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
C072790 SDZ 205-557 SDZ 205-557 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]decreases phosphorylation|decreases reaction 11880652
C072790 SDZ 205-557 SDZ 205-557 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]decreases reaction|increases phosphorylation 11880652
D020123 Sirolimus Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]decreases reaction|increases expression 17209049
D020123 Sirolimus Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
C071262 SK&F 82958 SK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]decreases phosphorylation|increases reaction 11880652
C071262 SK&F 82958 SK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]increases phosphorylation|increases reaction 11880652
C083009 SR 57227A SR 57227A results in decreased phosphorylation of PPP1R1B proteindecreases phosphorylation 11880652
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPP1R1B mRNAincreases expression 18465118
D014212 Tretinoin Tretinoin results in increased expression of PPP1R1B mRNAincreases expression 16026464
D014750 Vincristine PPP1R1B protein results in increased susceptibility to Vincristineincreases response to substance 17470401
C009687 wortmannin wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4714514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5517505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.6215814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Cisplatin 15.7117638652 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 15.7117418594
MESH:D000230 Adenocarcinoma Estradiol 15.7111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.7114692618
MESH:D000230 Adenocarcinoma Fluorouracil 15.7117638652
MESH:D000230 Adenocarcinoma Vincristine 15.7119825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6316835633
MESH:D000380 Agranulocytosis Clozapine 4.6812649775 16160616 14617031
MESH:D000419 Albuminuria Doxorubicin 4.1821441931
MESH:D000505 Alopecia Tretinoin 3.3215955085
MESH:D000740 Anemia Fluorouracil 7.5915504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5911748828
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D000855 Anorexia Quinpirole 5.7312183048
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.4116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1716292516
MESH:D001249 Asthma Tretinoin 2.2216456186
MESH:D001321 Autistic Disorder Acetaminophen 2.6718445737
MESH:D001321 Autistic Disorder Haloperidol 2.6718080171 19368416
MESH:D001321 Autistic Disorder Serotonin 2.6718062943 18405062 18361446 8570775 17157402 15132762 19221690
MESH:D001321 Autistic Disorder Sirolimus 2.6721115397
MESH:D001471 Barrett Esophagus Tretinoin 4.0416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 10.7614601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 10.7614601052
MESH:D001919 Bradycardia Serotonin 5.098112388
MESH:D001928 Brain Diseases, Metabolic 5-Methoxytryptamine 7.4118062943
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9517868700
MESH:D001930 Brain Injuries Progesterone 3.8915665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 3.4817150277
MESH:D001943 Breast Neoplasms Cisplatin 4.3819526202 18382427
MESH:D001943 Breast Neoplasms deguelin 4.3817035597 18593368
MESH:D001943 Breast Neoplasms Doxorubicin 4.3816115903 15634643 15668708 16826403 17426702 16322301 18628466 16595493 15994142 15136595 17369602 16264153 18382427 15692762 16935488 15993339 15567936 15939500 18234424 19526202 11325840 18695136 16096432 17983394
MESH:D001943 Breast Neoplasms Estradiol 4.3812948864 17289903 16675129 17261762 14630087 17018787 19861407 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 4.3818608205 16110121 19217205 16557594 15136595 18357371 16595493
MESH:D001943 Breast Neoplasms Progesterone 4.3815562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3820435547
MESH:D001943 Breast Neoplasms Tretinoin 4.3816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.0616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.0616051944
MESH:D002277 Carcinoma Fluorouracil 7.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.663084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 15.6617982673
MESH:D006528 Carcinoma, Hepatocellular deguelin 15.6618575727
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 15.6617876044 16023760 18059187 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.6616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.6617971768 18930000 16799960 16332177 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 15.6619335982
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.661917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9012023789 16685392
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.9316201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.9318695887
MESH:D002292 Carcinoma, Renal Cell Vincristine 9.9316201981
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 16.4918337622 17066447 6189445
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 16.496189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 16.4918986760 17066447 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 16.4919435901
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.4916096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Vincristine 16.496189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.2817007740 15811867 16455267 17519947 17382496 18627295 16612575 15792986 17974986 17928571 15476868 17351982 17308081 16364871 17924179 17131338 16242529 16952015 17329180 15505089 16109756 16731534 16269455 16651473 16278810
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8117334414 16243910
MESH:D002375 Catalepsy Haloperidol 4.5315215559 1977408
MESH:D002386 Cataract Acetaminophen 6.4710977129
MESH:D002386 Cataract Tretinoin 6.4717460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.5118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2116129372
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.0221254450
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.8117110522 16105132 17333356 11677210 15861022 17681005 16919318
MESH:D002779 Cholestasis pirinixic acid 6.8119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7716461808
MESH:D021081 Chronobiology Disorders Serotonin 6.3017157402
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.208697196 12621046 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.209407595
MESH:D003072 Cognition Disorders Clozapine 4.5917123785
MESH:D003092 Colitis Tretinoin 3.3317035595
MESH:D003110 Colonic Neoplasms Butyrates 3.8715936596
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8717169374 17016597 16510598 17172411 15001691 17018589 18772588 17725105 16340194 17287894
MESH:D015179 Colorectal Neoplasms Cisplatin 3.3215273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.3218802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.3218949393 17695437 18288408 15289873 16331619 18448328 15148649 17094418 17594712 14970324 16282729 16391804 17401013 18802399 18383874 16524972 17454858 20501625 16303861 18509181 17255274 17016601
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.3216925845 9664655 9211117 9142499 9224671 8800419 17551590 9125849 14991402 10589399
MESH:D007644 Darier Disease Fluorouracil 4.4116733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.4920210726
MESH:D003704 Dementia Haloperidol 4.2411575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.1616402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1217187935
MESH:D003967 Diarrhea 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 7.8810611417
MESH:D003967 Diarrhea Serotonin 7.8811488427 10446763 8112388
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1715331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.4616177239 16393943 10915739 11743745 16781746 12594235 14725611 15619225 14550746 19164858 16081117 11739529 12705907 18713872 11421492 19420014 11529661 16485898 11834606 10774834 16227642 19370779 19085960 2444490 17906064 17562736 11287661 19923254 11461765 15968718 18071297 12392966 14986274 12540782 10663392 19416960 16109766 17522070 12153990 12958197 19739265
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 5.4617416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.4620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Cisplatin 12.1412649298 12231392 15033597 19839026
MESH:D004362 Drug Toxicity Doxorubicin 12.1418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.1411462148
MESH:D050171 Dyslipidemias Clozapine 3.9116402076
MESH:D004487 Edema pirinixic acid 9.6412083418
MESH:D004487 Edema Serotonin 9.6418841975
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.6412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.6518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.8417692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.0217359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.0211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 11.0216569247
MESH:D004715 Endometriosis Progesterone 7.8416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.8410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7718037988
MESH:D004938 Esophageal Neoplasms Cisplatin 4.4116481741 15173087 17638652 15464296 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4116785472 15173087 17638652 16337965 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.909664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 6.4315345470
MESH:D005234 Fatty Liver pirinixic acid 6.4320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2119069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.3920067830
MESH:D005355 Fibrosis Tretinoin 7.3917994277
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D005909 Glioblastoma Doxorubicin 6.4117150277
MESH:D005909 Glioblastoma Tretinoin 6.4117312396
MESH:D005910 Glioma Fluorouracil 2.7116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 21.4715102660 15464296
MESH:D006258 Head and Neck Neoplasms Doxorubicin 21.4715692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 21.4715162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Sirolimus 21.4719435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 21.4716096774
MESH:D034381 Hearing Loss Cisplatin 3.9819898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7716084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1115464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8511294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.859664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.2216495754 18674790 18006777 16707910 16244372 17888722 14766674 16879835 17875725 16244371 16144979 12587719 16330681
MESH:D006333 Heart Failure Doxorubicin 6.2617481944
MESH:D006333 Heart Failure pirinixic acid 6.2620558911
MESH:D018883 Heat Stroke Ketanserin 6.7916205318
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5615692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006529 Hepatomegaly pirinixic acid 7.0316221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.0315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D006689 Hodgkin Disease Cisplatin 10.7016200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 10.7017606976 15147373 18501091
MESH:D006689 Hodgkin Disease Vincristine 10.7016794504 16135485 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6616959395 8697196 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 6.6316870215
MESH:D006930 Hyperalgesia Tretinoin 6.6316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2016778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006948 Hyperkinesis Clozapine 4.5316046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7618850075 18670907
MESH:D006984 Hypertrophy Sirolimus 4.8919211884
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4416945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2417937319
MESH:D007249 Inflammation Progesterone 4.3115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.3112878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.3616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.3616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8017551590 15992940
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7515464296
MESH:D007674 Kidney Diseases Acetaminophen 12.6212587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 12.6212231392 12649298 19839026 18289764 15190930
MESH:D007674 Kidney Diseases Doxorubicin 12.6215699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 12.6215618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8116707910
MESH:D007680 Kidney Neoplasms Estradiol 6.4715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 6.4716985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4111231351
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9.7012970779
MESH:D007938 Leukemia roscovitine 9.7016275999
MESH:D007938 Leukemia Tretinoin 9.7017143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7716085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9015748426 19075265 16331271 19035177 17368321 16891316 17107899 12679006 16935935 17649720 17301526 9834237 16766008 17712046 16140955 17506722 17339181 17361223 17217047 16788101 19225113 16823087 19029980 17294898 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.049224671
MESH:D008064 Lipidoses Clozapine 3.6917567588
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.0216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.0214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.0215474484
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 8.0217050028
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.0216248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.5419784758 16611625 19460945 11587558 12969438 16610002 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9117185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 6.4718383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 6.4720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.4716984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 5.1116842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.1112151625
MESH:D008175 Lung Neoplasms Cisplatin 7.8611798837 17225452 6189445
MESH:D008175 Lung Neoplasms deguelin 7.8619336726 16288123
MESH:D008175 Lung Neoplasms Doxorubicin 7.866189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 7.8615246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8611884234 19555203
MESH:D008175 Lung Neoplasms Vincristine 7.866189445 19825857
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4115086387
MESH:D008223 Lymphoma Doxorubicin 3.1916098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1915621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 8.5915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.5911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.5917203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Cisplatin 6.7412374674 16809738 17023156 15577323 11135225 18176117 18332650 16248763 12883367 17761969 12393984 18505091 16432458
MESH:D008545 Melanoma Doxorubicin 6.7416827129
MESH:D008545 Melanoma Sirolimus 6.7419282848
MESH:D008545 Melanoma Tretinoin 6.7416752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.8315990972
MESH:D018328 Melanoma, Amelanotic Vincristine 10.8315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008591 Meningomyelocele Tretinoin 4.0516940565
MESH:D001523 Mental Disorders Clozapine 7.1116856516
MESH:D001523 Mental Disorders Haloperidol 7.1116856516
MESH:D008654 Mesothelioma Cisplatin 5.9217638057
MESH:D008654 Mesothelioma Doxorubicin 5.9217638057
MESH:D024821 Metabolic Syndrome X Clozapine 4.1019142101
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1615792986
MESH:D009062 Mouth Neoplasms Fluorouracil 8.1216757204 18986760
MESH:D009062 Mouth Neoplasms Sirolimus 8.1219435901
MESH:D052016 Mucositis Doxorubicin 4.4117415656
MESH:D009128 Muscle Spasticity 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 5.7217220914
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8617596541
MESH:D009203 Myocardial Infarction Doxorubicin 8.6819429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 8.6819151258
MESH:D009203 Myocardial Infarction Vincristine 8.6817284715
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8018259882
MESH:D009369 Neoplasms Cisplatin 13.6716773208
MESH:D009369 Neoplasms deguelin 13.6717764071
MESH:D009369 Neoplasms Fluorouracil 13.6718239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 13.6717405874
MESH:D009369 Neoplasms Tretinoin 13.6716946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1115464296
MESH:D009401 Nephrosis Doxorubicin 4.4016899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.6815640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 14.2416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.2414600291
MESH:D009421 Nervous System Malformations Tretinoin 14.249125849
MESH:D009436 Neural Tube Defects Tretinoin 2.819142499
MESH:D009447 Neuroblastoma Cisplatin 6.478761367
MESH:D009447 Neuroblastoma Doxorubicin 6.4715555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5618514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.558761367
MESH:D017599 Neuroectodermal Tumors Vincristine 10.5512837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1816436463
MESH:D009765 Obesity Clozapine 4.3519142110 18515891
MESH:D009765 Obesity pirinixic acid 4.3520558911
MESH:D012516 Osteosarcoma Doxorubicin 3.8115930896
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13.5916211241
MESH:D010051 Ovarian Neoplasms Cisplatin 13.5919769630 6897625 17225452 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 13.5919401270
MESH:D010051 Ovarian Neoplasms Progesterone 13.5916525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 13.5916936753
MESH:D010146 Pain 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 9.6918987195
MESH:D010146 Pain Acetaminophen 9.6916870215
MESH:D010146 Pain Tretinoin 9.6916870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 7.8519003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.8519003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.8515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010300 Parkinson Disease Sirolimus 3.5919682553
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9515464296
MESH:D010554 Personality Disorders 5-Methoxytryptamine 7.0618062943
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7717983394
MESH:D010997 Pleural Neoplasms Cisplatin 12.6417638057
MESH:D010997 Pleural Neoplasms Doxorubicin 12.6417638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.4121297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8111118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.2615897917 16729912 16868541 16888761 15749863 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 2.2616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2618626508 19082440
MESH:D011471 Prostatic Neoplasms roscovitine 2.2616140939
MESH:D011507 Proteinuria Tretinoin 3.2616636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9315861022 16919318
MESH:D011595 Psychomotor Agitation Haloperidol 4.5811575062
MESH:D011618 Psychotic Disorders Clozapine 8.2515331141
MESH:D011618 Psychotic Disorders Haloperidol 8.2511575062
MESH:D011625 Pterygium Tretinoin 4.4116723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6918722050 18286688 16160472 15538739
MESH:D051437 Renal Insufficiency Cisplatin 9.1415464296
MESH:D051437 Renal Insufficiency Doxorubicin 9.1417922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7516283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7218045962
MESH:D012509 Sarcoma Doxorubicin 3.6616767912 17710206 17203757 18313854 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Cisplatin 15.4414601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 15.4416326096 14601052
MESH:D012512 Sarcoma, Ewing's roscovitine 15.4416230394
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4117846226
MESH:D012559 Schizophrenia Clozapine 3.8811151749 17726453 18806925 20580759 20452607 11763009 20521320 18855531 17123785 20107430 19369910 20521326 20168265 16141801 17667964
MESH:D012559 Schizophrenia Haloperidol 3.8818513383 19369910 1830565 20107430
MESH:D012640 Seizures 5-Methoxytryptamine 5.0618062943
MESH:D012878 Skin Neoplasms deguelin 12.1016041863
MESH:D012878 Skin Neoplasms Doxorubicin 12.1015692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.1016192470
MESH:D012878 Skin Neoplasms Tretinoin 12.1016467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9515464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1916767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5516709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9015862959 16503802
MESH:D013274 Stomach Neoplasms Cisplatin 3.2317522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2315786421 19015929 17172411 16951190 17522103 18567086 19084572 17498489 16424979 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 3.2317261132
MESH:D015173 Supratentorial Neoplasms Vincristine 5.4912837982
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.3520210726
MESH:D024801 Tauopathies Camptothecin 5.2416930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.2815464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms Butyrates 10.4917967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.4917909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 10.4916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.7316280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.7316051514
MESH:D014376 Tuberculosis Tretinoin 2.9916040207
MESH:D014402 Tuberous Sclerosis Sirolimus 5.2021115397 18495876
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 4.9015464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 4.9017653716
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 14.0116803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.0116803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.0116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2216752155
MESH:D014605 Uveitis Sirolimus 5.241336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2415577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2015869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8517638931 17334414 17678736 16364871
MESH:D014820 Vitiligo Tretinoin 3.6916761959
MESH:D014839 Vomiting Cisplatin 4.3311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Clozapine 4.1520521320 20107430 20564506 17502770 16402076 16141801
MESH:D015431 Weight Loss Clozapine 4.7017933447
MESH:D009396 Wilms Tumor Tretinoin 3.6516287080
Pathway ID Pathway Name
REACT:15295 Opioid Signalling
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33639
    • No data
    Releated disease ID Related disease Name
    PA443265Adenocarcinoma
    PA444635Intestinal Neoplasms
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449396dopamine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved