AutismKB 2.0

Annotation Detail for ANTXR1


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Basic Information Top
Gene Symbol:ANTXR1 ( ATR,FLJ10601,FLJ11298,FLJ21776,TEM8 )
Gene Full Name: anthrax toxin receptor 1
Band: 2p13.3
Quick LinksEntrez ID:84168; OMIM: 606410; Uniprot ID:ANTR1_HUMAN; ENSEMBL ID: ENSG00000169604; HGNC ID: 21014
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200179Cellular roles of Anthrax toxin
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Related Diseases/Disorders Top
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Desease Name
Hemangioma, capillary infantile, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANTXR1 mRNAdecreases expression 19150397
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ANTXR1 mRNAincreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ANTXR1 mRNAincreases expression 17484886
D004041 Dietary Fats Dietary Fats results in increased expression of ANTXR1 mRNAincreases expression 18042831
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of ANTXR1 mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ANTXR1 mRNAincreases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of ANTXR1 intronincreases mutagenesis 16300676
C056507 gemcitabine gemcitabine affects the expression of ANTXR1 mRNAaffects expression 17039268
C041786 palm oil palm oil results in increased expression of ANTXR1 mRNAincreases expression 18042831
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of ANTXR1 mRNAaffects cotreatment|increases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ANTXR1 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Estradiol 4.3411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3414692618
MESH:D000236 Adenoma Ethylnitrosourea 3.816695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.6415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0414991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15380490 15845082
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4516651633 15144691 16357521 16436596 18412241
MESH:D001943 Breast Neoplasms Dietary Fats 2.3920435547
MESH:D001943 Breast Neoplasms Estradiol 2.3917261762 17289903 19861407 12948864 14630087 16675129 18497071 17018787
MESH:D001943 Breast Neoplasms gemcitabine 2.3917039268 18382427
MESH:D001943 Breast Neoplasms Progesterone 2.3917614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915673190 18705752 16050911 15721981 16227642 15700767 16192424 16011737 16124888 16097048 10355542 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0516924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9818566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 11.9816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2517160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0016105132 15861022 17681005 16919318 17333356 11677210 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 12621046 8697196 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.877120509 11566570 19336974 15998439 3732212 6623471 3786805 15968718 6884620 19085960 2869522 17522070 10915739 16177239 7179309 4309450 15027814 7440962 16227642 9327722 21278145 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2518357618
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.7017692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0911473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 9.4716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.4710568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.1315959796 61145 16045604 12631006 16239168 12795759 17595544 19224547
MESH:D005234 Fatty Liver Dietary Fats 14.1317967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.1315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.0718705752
MESH:D005355 Fibrosis Dietary Fats 16.0718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0720067830
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9416436596
MESH:D005910 Glioma Ethylnitrosourea 3.5518412241 16651633 16357521
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:C535860 Hemangioma, capillary infantile marker/mechanism
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 18606429 8697196 16959395 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Dietary Fats 8.7920412841
MESH:D007249 Inflammation Progesterone 8.7915869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.7311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.7316393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Estradiol 2.6715618244
MESH:D007680 Kidney Neoplasms Estradiol 8.2015610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.2017379185
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9217334410 11408273 21278145 16943688 17174718 11903743 17157831 16221502 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5316015684 12741479 17708605 12586293 12445418 17640975 12666154 15876570 17823541 18156304 14512876 18429990 15370692 10355542 14716496 12632514 15925388 15730626 17557913 16027843 18006644 18279442 14620537 12445421 12389079 15673190 17698563 13678700 17761835 16248980 15818738 18210741 12898905 17721639 17714472 15338365 18054572 17525996 18412020 18205269 18376398 12667390 12546737 18418968 18251166 12958196 18395914 17805973 17481882 15996030 16097048 15893842 18472332 16033810 17869086 11481614 16011737 17976157 15959796 18481824 14716833 20821823 17631135 15052691 14748882 16192424 15057751 15931870 17900296 18472094 17766677 17944888 17565644 17922224 12609069 18317297 16136751 18187930 15650968 16638106 15123356 18339082 18395095 18166357 18277467 18705752 16116963 18420326 15362042 18263696 14724832 12632512 12649538
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215830285 16964402 16246199 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6217703301 16271038 6695378 16019985
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6211884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 4.0615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2615375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.7217203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 10.7218041768 10838139 10767621
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.7211408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008579 Meningioma Ethylnitrosourea 6.2517943659
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6216707424
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 10.1416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6517160924 16003739 16651423
MESH:D009765 Obesity Dietary Fats 2.3219632207 11836018 18674790 18457598 20518802 16723640 21332399 17217161 20132043
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2517160924
MESH:D010051 Ovarian Neoplasms Estradiol 5.0319401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.0316525653 17393432
MESH:D010190 Pancreatic Neoplasms gemcitabine 3.5916929163 17440100 18992248 18383843 11504793
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11399792 11118676 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.5216503802 15862959
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4015790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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