AutismKB 2.0

Annotation Detail for STX7


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Basic Information Top
Gene Symbol:STX7 ( - )
Gene Full Name: syntaxin 7
Band: 6q23.2
Quick LinksEntrez ID:8417; OMIM: 603217; Uniprot ID:STX7_HUMAN; ENSEMBL ID: ENSG00000079950; HGNC ID: 11442
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04130SNARE interactions in vesicular transport
Pathway IDPathway Name
Botulinum neurotoxicity
No data
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
P00049Parkinson disease
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of STX7 mRNAincreases expression 19417177
20406850
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STX7 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of STX7 mRNAdecreases expression 15336504
D006220 Haloperidol Haloperidol results in decreased expression of STX7 mRNAdecreases expression 15860345
D014635 Valproic Acid Valproic Acid results in increased expression of STX7 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001321 Autistic Disorder Haloperidol 2.3419368416 18080171
MESH:D001321 Autistic Disorder Valproic Acid 2.3418177632 15238991 20603192 18985861 18396377 17157402 19232924 17507914 19460635 17688650 16609825 18316065 18940202 18558336 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7916705839
MESH:D002375 Catalepsy Haloperidol 5.4515215559 1977408
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.006135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.2520210726
MESH:D003704 Dementia Haloperidol 4.9511575062
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.2121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.2119641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.643659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.5316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.917562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D005234 Fatty Liver Valproic Acid 3.6719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5718558336 8888407
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2816705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.257678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.742876784 2876786 6135515
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D001523 Mental Disorders Haloperidol 4.5516856516
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.4018551238 7678174
MESH:D009436 Neural Tube Defects Valproic Acid 3.3416359493 8888407
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 5.4411575062
MESH:D011618 Psychotic Disorders Haloperidol 4.5011575062
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Haloperidol 3.9918513383 19369910 1830565 20107430
MESH:D012559 Schizophrenia Valproic Acid 3.9919110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7218551238
MESH:D012640 Seizures Valproic Acid 6.7211044598 11738929 3137016 14763951 1511512 16876388 15475178 17978042
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.838532709
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.1520210726
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4016049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
Pathway ID Pathway Name
REACT:11184 Botulinum neurotoxicity
KEGG:04145 Phagosome
KEGG:04130 SNARE interactions in vesicular transport
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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