AutismKB 2.0

Annotation Detail for FAR1


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Basic Information Top
Gene Symbol:FAR1 ( DKFZp686A0370,DKFZp686P18247,FLJ22728,FLJ33561,MLSTD2,SDR10E1 )
Gene Full Name: fatty acyl CoA reductase 1
Band: 11p15.3
Quick LinksEntrez ID:84188; OMIM: NA; Uniprot ID:FACR1_HUMAN; ENSEMBL ID: ENSG00000197601; HGNC ID: 26222
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04146Peroxisome
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500822Plasmalogen biosynthesis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FAR1 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FAR1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FAR1 mRNAdecreases expression 19150397
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FAR1 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FAR1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAR1 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FAR1 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAR1 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid Valproic Acid results in increased expression of FAR1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4615322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D000236 Adenoma Benzo(a)pyrene 11.966695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.9619389873
MESH:D000236 Adenoma Diethylnitrosamine 11.966695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.3617162532 19061943 18056438 19052882 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.3616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.3616835633
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9918940202 18316065 17688650 17507914 19460635 15238991 18177632 18558336 19232924 18985861 17157402 18775368 18396377 16609825 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.508888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8020146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8720935162 18056438 17761372 16779866 20084675 11831363 18785209 18971187 20524982 10737359 17428255 19822196 16807293 20007298 19394651 18665156 19519916 19335982 18393292 20512989 16878318 3581430 17138121 19418558 3084413 20101231 17055752 18978308 18210153 17162532 19171122 19383236 18788625 19107877 19208518 18494052 19539802 20432363 17978847 21159647 10672840 18691550 19919837 16681979 16502159 16935385 17173139 16698587 16540662 20727157 20514400 16569478 20214788 18506893 16830150 19701751 16328049 19052882 16288022
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.2117174075 21159647 2727394 7505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.0519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.0516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3315861022 17681005 16105132 16919318 11677210 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 8697196 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5317688650 8888407 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3817107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.561733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Diethylnitrosamine 20.8720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8715345470
MESH:D005234 Fatty Liver pirinixic acid 20.8719236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 20.8719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 16959395 16354765 15340226
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Diethylnitrosamine 5.2718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418522880 18407596 20032147 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.0921137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 15.0919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.0912112319 15885732 12771043 19073162 19638242 2422723 20137499 21167192 20583210 19090486 21278145 19850985 18977376 20434301 19294768 16942905 19254457 19551842 20101389 2862719 18648771 19642983 15175105 19833225 19255062 19427195 18754104 20501860 19996281 21071580 18644402 21047994 19690152 18978307 19499222 20118626 19426721 19812893 10737359 20405173 9163691 20492335 20452335 19256749
MESH:D008113 Liver Neoplasms pirinixic acid 15.0920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0916984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.6918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.6918093689 19539802 17854601 16267830 16842330 18282651 2563599 18775883 19126423 19009564 3124819 17942915 9362446 18164116 21159647 18079962 17174075 18544905 18308698 18253720 19519916 19004024
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6912151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4718816296 6695378 18569708 17053015 20464547 20064080 20869020 20135361 18520028
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4720970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4711884234 19555203
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6111399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.6120603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.9211422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8911044598 15475178 1511512 17978042 3137016 11738929 14763951 16876388
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3820155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3818456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04146 Peroxisome
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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