AutismKB 2.0

Annotation Detail for TRAF7


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Basic Information Top
Gene Symbol:TRAF7 ( DKFZp586I021,MGC7807,RFWD1,RNF119 )
Gene Full Name: TNF receptor-associated factor 7
Band: 16p13.3
Quick LinksEntrez ID:84231; OMIM: 606692; Uniprot ID:TRAF7_HUMAN; ENSEMBL ID: ENSG00000131653; HGNC ID: 20456
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TRAF7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TRAF7 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TRAF7 mRNAaffects expression 16483693
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TRAF7 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of TRAF7 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Tamoxifen 2.1720005174 19244106 18629630 16818667 20135344 19066611 18855134 19115204 18425577 19221464 17242785 17440819 18984771 15565566 16202921 19487384 19155303 19103187 19142967 17893378 11161223 20544844 19289846 17049068 18351453 21152245 19084267 20390343 20065188 19011961 16273361 18821012 18997820 21138602 18815881 19410462 19288272 19189212 19059307 15668708 19189210 19200415 16873071 17261762 20859285
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.763084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7616924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1315861022 16105132 17110522 17681005 11677210 16919318 17333356
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9917522070 16485898 16081117 19416960 15968718 16393943 16109766 11739529 12392966 11743745 16177239 10915739 11834606 18713872 12958197 14725611 15619225 19739265 11421492 19420014 10774834 10663392 14986274 16781746 19085960 11529661 16227642 11461765 17562736 17906064 12594235 14550746 12153990 19164858 19370779 2444490 19923254 18071297 12540782 11287661 12705907
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2617893378 20544844 16202921 19155303
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.9615345470
MESH:D005234 Fatty Liver Tamoxifen 8.9619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.4116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.4118625569
MESH:D008064 Lipidoses Tamoxifen 3.4017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 19460945 19784758 12969438 16611625 11587558 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms Tamoxifen 2.3216684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8314580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119200415 19196722 19189210
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7812819281 16049721
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4216049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.4216712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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