AutismKB 2.0

Annotation Detail for POLDIP3


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Basic Information Top
Gene Symbol:POLDIP3 ( KIAA1649,PDIP46,SKAR )
Gene Full Name: polymerase (DNA-directed), delta interacting protein 3
Band: 22q13.2
Quick LinksEntrez ID:84271; OMIM: 611520; Uniprot ID:PDIP3_HUMAN; ENSEMBL ID: ENSG00000100227; HGNC ID: 23782
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200080mTOR signaling pathway
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of POLDIP3 mRNAaffects expression 17562736
D012643 Selenium Selenium results in increased expression of POLDIP3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.9110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8310977129
MESH:D003092 Colitis Selenium 4.5417936198
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1619739265 14986274 12594235 16227642 12153990 19370779 19164858 11834606 18713872 19085960 11529661 19416960 2444490 11461765 19923254 18071297 15619225 11287661 16485898 16393943 10663392 10915739 14725611 17906064 19420014 11421492 11743745 17522070 12540782 17562736 11739529 12705907 16781746 10774834 14550746 16177239 16109766 15968718 12958197 16081117 12392966
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1615131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 5.1719426721
MESH:D005756 Gastritis Acetaminophen 4.7416983495
MESH:D006333 Heart Failure Selenium 3.3417162251
MESH:D006930 Hyperalgesia Acetaminophen 3.1116870215
MESH:D007251 Influenza, Human Selenium 5.2716624496
MESH:D007674 Kidney Diseases Acetaminophen 2.4415629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 4.4416518626
MESH:D008107 Liver Diseases Acetaminophen 1.7111587558 12969438 16611625 19784758 19460945 19014921 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.7417185352 16871587
MESH:D008325 Mammary Neoplasms, Experimental Selenium 3.0515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.3319513568
MESH:D008654 Mesothelioma Selenium 2.9415107826
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.3118514411
MESH:D010146 Pain Acetaminophen 2.8216870215
MESH:D010954 Plasmacytoma Selenium 5.9615087411
MESH:D014581 Urticaria Acetaminophen 3.5810982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018