AutismKB 2.0

Annotation Detail for DDI2


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Basic Information Top
Gene Symbol:DDI2 ( MGC14844,RP4-680D5.5 )
Gene Full Name: DNA-damage inducible 1 homolog 2 (S. cerevisiae)
Band: 1p36.21
Quick LinksEntrez ID:84301; OMIM: NA; Uniprot ID:DDI2_HUMAN; ENSEMBL ID: ENSG00000197312; HGNC ID: 24578
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DDI2 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of DDI2 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of DDI2 mRNAdecreases expression 18042831
D004041 Dietary Fats Dietary Fats results in increased expression of DDI2 mRNAincreases expression 18042831
C041786 palm oil palm oil results in decreased expression of DDI2 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in increased expression of DDI2 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of DDI2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of DDI2 mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of DDI2 mRNAincreases expression 18445702
D018038 Sodium Selenite Sodium Selenite results in decreased expression of DDI2 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DDI2 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4414514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.3717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.3716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.3716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.9720007298 17173139 1701930 6705139 20935162
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15340226 12621046 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5115619225 10915739 11529661 11287661 19923254 18071297 16177239 14550746 11739529 10663392 2444490 17906064 19370779 12153990 17562736 12540782 12594235 19085960 16393943 15968718 19164858 17522070 19420014 11421492 16081117 14725611 18713872 16781746 16485898 12958197 16109766 12705907 12392966 14986274 11743745 11461765 10774834 19739265 19416960 11834606 16227642
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Dietary Fats 8.5219551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 8.5219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Dietary Fats 9.6618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Phenobarbital 16.2516109766
MESH:D006529 Hepatomegaly pirinixic acid 16.2518467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.2515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 15340226 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007249 Inflammation Dietary Fats 5.2920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 13.2118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 13.2116306350
MESH:D007333 Insulin Resistance Sodium Selenite 13.2114714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Acetaminophen 4.1019460945 16610002 19014921 16611625 12969438 11587558 19784758 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Phenobarbital 7.8121047994 15975961 19482888 19073162 8742319 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 7.8115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8116984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.2617172636 2563599 1399818 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity Dietary Fats 4.6020132043 19632207 18457598 17217161 16723640 21332399 18674790 20518802 11836018
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3518760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures Phenobarbital 2.8411442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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