Annotation Detail for NUDT16L1
Basic Information
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| Gene Symbol: | NUDT16L1 ( MGC11275,SDOS ) |
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| Gene Full Name: | nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 |
|---|
| Band: | 16p13.3 |
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| Quick Links | Entrez ID:84309; OMIM: NA; Uniprot ID:SDOS_HUMAN; ENSEMBL ID: ENSG00000168101; HGNC ID: 28154 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| 200115 | Syndecan-4-mediated signaling events |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of NUDT16L1 mRNA | affects expression | 17562736
|
| D016572 |
Cyclosporine |
Cyclosporine results in decreased expression of NUDT16L1 mRNA | decreases expression | 20106945
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NUDT16L1 mRNA | affects binding|decreases expression|increases activity | 19710929
|
| C006253 |
pirinixic acid |
pirinixic acid results in decreased expression of NUDT16L1 mRNA | decreases expression | 17426115
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.64 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.22 | 16434500 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.71 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.39 | 18445737 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.63 | 19483382 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
1.41 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.81 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
2.82 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
8.86 | 19486331 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
8.86 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.59 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
1.68 | 16081117 10915739 19416960 18713872 16227642 15619225 11834606 16393943 19739265 17906064 15968718 12540782 19370779 12392966 14986274 11287661 17562736 11529661 10774834 10663392 16109766 19164858 12958197 14550746 16781746 19923254 16177239 12153990 14725611 19420014 11421492 16485898 17522070 2444490 11461765 11739529 19085960 12594235 18071297 12705907 11743745 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.96 | 19426721 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.96 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
9.21 | 19224547 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
9.21 | 20131406 19236843 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.79 | 12639820 12168785 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.54 | 16983495 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.96 | 8708960 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.78 | 20558911 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
5.16 | 15720958 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.64 | 16221962 18467677 19772884 19176532 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.06 | 16870215 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.63 | 20558911 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.23 | 10903974 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.90 | 16306350 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.31 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
6.55 | 15629191 12587719 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
6.55 | 8314463 10903974 18776723 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
3.12 | 12371664 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.71 | 16611625 12969438 12587719 19460945 11587558 19014921 19784758 16610002 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.68 | 17185352 16871587 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.94 | 16377806 20007298 15890375 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.22 | 19513568 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.65 | 16801185 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.16 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.29 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.29 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.12 | 17405874 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.31 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.70 | 19348381 18481113 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.26 | 18514411 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.89 | 20558911 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.77 | 16870215 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.64 | 12371664 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.34 | 16882103 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.56 | 19058328 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.50 | 10982225 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.85 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.31 | 17120751 |
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