AutismKB 2.0

Annotation Detail for SOAT2


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Basic Information Top
Gene Symbol:SOAT2 ( ACACT2,ACAT2,ARGP2,MGC116732 )
Gene Full Name: sterol O-acyltransferase 2
Band: 12q13.13
Quick LinksEntrez ID:8435; OMIM: 601311; Uniprot ID:SOAT2_HUMAN; ENSEMBL ID: ENSG00000167780; HGNC ID: 11178
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00100Steroid biosynthesis
No data
No data
Pathway IDPathway Name
P02727Androgen/estrogene/progesterone biosynthesis
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
plasma HDL-C levels
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SOAT2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SOAT2 mRNAaffects expression 16483693
D004391 Dust Dust results in decreased expression of SOAT2 mRNAdecreases expression 17805423
D005632 Fructose Fructose results in decreased expression of SOAT2 mRNAdecreases expression 19193814
C011890 kojic acid kojic acid results in increased expression of SOAT2 mRNAincreases expression 16595896
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SOAT2 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 15668235 8697196 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D003327 Coronary Disease Fructose 4.6618504504
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.7618603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 4.8718603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.8717107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8119739265 16227642 11287661 19420014 12705907 16081117 16781746 17562736 14725611 12540782 18713872 15619225 19416960 19923254 12153990 11834606 10915739 16109766 10663392 2444490 11461765 19085960 17906064 16393943 14986274 15968718 18071297 10774834 17522070 11739529 12392966 19370779 19164858 12958197 11743745 12594235 16177239 11421492 14550746 11529661 16485898
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Fructose 4.7019196556 18641190 18395287
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Fructose 10.4718504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.4720067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D018149 Glucose Intolerance Fructose 5.6819165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3112621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716354765 15340226 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006946 Hyperinsulinism Fructose 5.1618360027 19008412 14757778 18563319 15752949
MESH:D006949 Hyperlipidemias Fructose 5.1015752949
MESH:D006973 Hypertension Fructose 5.8414633139 19008412 16843071 14568997 14573337
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.8418850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 5.3819342510 19799862
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007333 Insulin Resistance Fructose 4.4314757778 14633139 19586609 18563319 17133782 19799862 19008412 18057795 19342510 18981581 14573337
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 11587558 19784758 16611625 19014921 12587719 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.6318544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.6312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D024821 Metabolic Syndrome X Fructose 5.0918497449 17261469 16815490 19165636 17098227
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Fructose 3.4817707055 18585860
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11896295 11222880 11118676
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:00100 Steroid biosynthesis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01094 antagonist Hesperetin Anticholesteremic Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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