AutismKB 2.0

Annotation Detail for RASAL1


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Basic Information Top
Gene Symbol:RASAL1 ( RASAL )
Gene Full Name: RAS protein activator like 1 (GAP1 like)
Band: 12q24.13
Quick LinksEntrez ID:8437; OMIM: 604118; Uniprot ID:RASL1_HUMAN; ENSEMBL ID: ENSG00000111344; HGNC ID: 9873
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene AHR protein affects the reaction [Benzo(a)pyrene results in increased expression of RASAL1 mRNA]affects reaction|increases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RASAL1 mRNAincreases expression 20064835
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of RASAL1 mRNAdecreases expression 19371625
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RASAL1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RASAL1 mRNAincreases expression 20064835
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4715322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4420127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.9915469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8520146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.8517129689 15324884
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 2.2715948411 16924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5616120746 18670907 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1716919318 11677210 16105132 15861022 17681005 17110522 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.248697196 12621046 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 5.0616002989 12952375
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6912538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.3216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.7015700306 16804899
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.429294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.2415345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8716513791 16534752 16611131 15751030 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.5816452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0511294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7715340226 18606429 16959395 8697196 16354765
MESH:D006965 Hyperplasia Diethylstilbestrol 5.0012960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 13.1816002989
MESH:D007021 Hypospadias Ethinyl Estradiol 13.1816569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.8615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.8016762066 14681315 15003126
MESH:D007859 Learning Disorders Diethylstilbestrol 4.6217184923
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.1420195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 8.1415890375 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.1416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2720064080 20135361 18520028 6695378 17053015 18816296 20464547 18569708 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2719555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.7815166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.7515700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.2416002989
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6911141357
MESH:D009369 Neoplasms Diethylstilbestrol 5.6915313581
MESH:D009421 Nervous System Malformations Diethylstilbestrol 11.3811399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.3814600291
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.8914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.2315687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 11.7617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.7611896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2017292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2015846301 17136230 15046698
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0016192470
MESH:D013088 Spermatocele Diethylstilbestrol 14.2616709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 14.2616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5717053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.5716712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.4316175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.8914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 11.2116690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 11.2114692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 5.0016002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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