AutismKB 2.0

Annotation Detail for RAD54L


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Basic Information Top
Gene Symbol:RAD54L ( HR54,RAD54A,hHR54,hRAD54 )
Gene Full Name: RAD54-like (S. cerevisiae)
Band: 1p34.1
Quick LinksEntrez ID:8438; OMIM: 603615; Uniprot ID:RAD54_HUMAN; ENSEMBL ID: ENSG00000085999; HGNC ID: 9826
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03440Homologous recombination
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
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Desease Name
Adenocarcinoma, colonic, somatic
Breast cancer, invasive ductal
Lymphoma, non-Hodgkin, somatic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of RAD54L mRNAincreases expression 20713471
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RAD54L proteinaffects expression 20106945
C103505 AM 251 AM 251 results in decreased expression of RAD54L mRNAdecreases expression 16500647
C015001 arsenite arsenite results in decreased expression of RAD54L mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RAD54L mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RAD54L mRNAincreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RAD54L mRNAaffects expression 17484886
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]decreases reaction|increases expression 16417649
D005047 Etoposide Etoposide results in increased expression of RAD54L proteinincreases expression 16417649
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of RAD54L mRNAincreases expression 20713471
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RAD54L mRNAdecreases expression 16714409
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RAD54L mRNAaffects cotreatment|affects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RAD54L mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D000169 Acrodermatitis Zinc 5.6017202136 17190629 16889938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.136695378
MESH:D000236 Adenoma Methylcholanthrene 7.136695378 10545420
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000544 Alzheimer Disease Zinc 2.7816410023 16325427 16580781 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.0616916123
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001249 Asthma Zinc 2.9917085522
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5311922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.3814601052
MESH:D001930 Brain Injuries Zinc 4.8617109824
MESH:D001943 Breast Neoplasms marker/mechanism
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.4011921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4017474063 20146248
MESH:D001943 Breast Neoplasms Etoposide 2.4016322251
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.4017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.953786805 15700767 16192424 16227642 10355542 15673190 16097048 15721981 16124888 18705752 16011737 16050911
MESH:D002277 Carcinoma Methylcholanthrene 8.7110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7116835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1118788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8920419170
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.8918922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.8916543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.7516936243
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.5916192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms arsenite 2.6015037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 2.7119302082
MESH:D003920 Diabetes Mellitus Zinc 4.3316479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.849327722 11566570 19336974 3732212 19085960 21278145 3786805 15027814 7440962 6884620 17522070 15998439 15968718 6623471 16227642 10092053 7120509 10915739 16177239 2869522 4309450 7179309
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4212711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.4215177302 7812673 8273558 8113982 16716910 9599246 11698051
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7416530937
MESH:D004938 Esophageal Neoplasms Zinc 4.7416543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenite 8.5218296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.5215959796 12795759 17595544 16045604 16239168 61145 12631006 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1310962813 14633661
MESH:D005355 Fibrosis arsenite 15.9018296743
MESH:D005355 Fibrosis Carbon Tetrachloride 15.9018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.9020067830
MESH:D005756 Gastritis Zinc 5.0117241300
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006130 Growth Disorders Zinc 4.0517217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006333 Heart Failure Zinc 3.6917162251
MESH:D006335 Heart Injuries Zinc 5.9917074742
MESH:D016481 Helicobacter Infections Zinc 4.6817241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 4.8617276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0716120746 12621046 15340226
MESH:D006561 Herpes Simplex Etoposide 4.7610809021
MESH:D006689 Hodgkin Disease Etoposide 3.9916135485 18180244 16200630 17606976 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 15340226 18606429 8697196 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3812878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 5.387812673 8273558 7562506 15177302 11698051
MESH:D007511 Ischemia Zinc 4.8116584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Zinc 3.3916960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5616518626
MESH:D008103 Liver Cirrhosis arsenite 7.0718296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0711408273 16943688 17174718 16239168 16221502 17334410 21278145 17157831 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3220821823 15338365 17944888 18054572 18376398 17805973 10355542 17761835 17640975 12649538 16192424 12666154 18317297 17823541 18418968 15959796 15996030 12389079 15650968 18277467 17557913 18472094 15893842 17698563 12546737 18420326 18429990 15925388 18395914 14512876 17565644 14620537 11481614 15370692 17631135 17869086 18279442 15673190 16116963 18006644 17721639 17481882 13678700 16136751 12958196 18481824 17525996 14716496 18251166 18166357 12741479 16097048 17714472 15052691 18205269 14716833 12667390 18210741 15123356 18263696 12898905 17708605 15362042 16248980 18412020 16015684 12586293 12609069 18339082 17900296 15876570 16638106 17766677 18395095 14724832 12445418 15057751 16033810 16027843 15730626 12445421 12632514 18187930 16011737 12632512 15931870 18705752 18472332 18156304 14748882 17976157 17922224 15818738
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1116246199 15830285 15720792 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8214706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.092125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0921137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.858603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.8515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.85598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8512151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.7714755239
MESH:D008175 Lung Neoplasms arsenite 8.7716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.7718569708 20135361 18816296 6695378 20464547 20869020 17053015 18520028 20064080
MESH:D008175 Lung Neoplasms Methylcholanthrene 8.777750092 16271038 10545420 20512841 20970405 6695378 1399818 21163286 16337739 17909032 9230183 15390079 11893704
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.7711884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.7711807781
MESH:D008223 Lymphoma Etoposide 4.0212854902 12556972
OMIM:605027 LYMPHOMA, NON-HODGKIN, FAMILIAL marker/mechanism
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 10.7811921183
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 10.788985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 10.7812773700
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009389 Neovascularization, Pathologic arsenite 4.6115738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D010146 Pain AM 251 4.4018987195
MESH:D010190 Pancreatic Neoplasms AM 251 9.2616500647
MESH:D010190 Pancreatic Neoplasms Etoposide 9.2619003803
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 9.2615976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.4718922899 18404319 12065085 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011225 Pre-Eclampsia Zinc 4.2817114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6917292933
MESH:D011471 Prostatic Neoplasms Etoposide 2.6917172428
MESH:D011471 Prostatic Neoplasms Zinc 2.6916606632 16700911 12429649 16517595
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration Zinc 4.2316584753
MESH:D012512 Sarcoma, Ewing's Etoposide 4.8614601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8316192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.838330346 12065085 18404319 8985016 11807781
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014062 Tongue Neoplasms Zinc 4.5316543248
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:03440 Homologous recombination
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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