AutismKB 2.0

Annotation Detail for NCK2


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Basic Information Top
Gene Symbol:NCK2 ( GRB4,NCKbeta )
Gene Full Name: NCK adaptor protein 2
Band: 2q12.2
Quick LinksEntrez ID:8440; OMIM: 604930; Uniprot ID:NCK2_HUMAN; ENSEMBL ID: ENSG00000071051; HGNC ID: 7665
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04012ErbB signaling pathway
hsa04360Axon guidance
hsa05130Pathogenic Escherichia coli infection
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Axon guidance
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Signaling by PDGF
Pathway IDPathway Name
200012Insulin Pathway
200084IGF1 pathway
200173Ephrin B reverse signaling
200051Reelin signaling pathway
Pathway IDPathway Name
P00053T cell activation
P00005Angiogenesis
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NCK2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NCK2 mRNAaffects expression 17562736
D002166 Camptothecin Camptothecin results in decreased expression of NCK2 mRNAdecreases expression 17374387
D016572 Cyclosporine Cyclosporine results in increased expression of NCK2 mRNAincreases expression 20106945
D003630 Daunorubicin Daunorubicin results in decreased expression of NCK2 mRNAdecreases expression 17374387
D005047 Etoposide Etoposide results in decreased expression of NCK2 mRNAdecreases expression 17374387
C029424 hydrazine hydrazine results in decreased expression of NCK2 mRNAdecreases expression 15282401
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of NCK2 mRNAincreases expression 17572062
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of NCK2 mRNAdecreases expression 20713471
D010615 Phenacetin Phenacetin results in decreased expression of NCK2 mRNAdecreases expression 17082564
C030299 phenylhydrazine phenylhydrazine results in decreased expression of NCK2 mRNAdecreases expression 17082564
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NCK2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of NCK2 mRNAincreases expression 18301758
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of NCK2 mRNAdecreases expression 17951470
D014638 Vanadates Vanadates results in increased expression of NCK2 proteinincreases expression 17874149
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.013712494
MESH:D000236 Adenoma Methylcholanthrene 7.016695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000740 Anemia Phenacetin 10.062444515
MESH:D000740 Anemia phenylhydrazine 10.062444515
MESH:D000743 Anemia, Hemolytic Phenacetin 11.241949026 17698508 17082564
MESH:D000743 Anemia, Hemolytic phenylhydrazine 11.2417698508 17084956 17082564
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4811922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.2614601052
MESH:D001943 Breast Neoplasms Etoposide 2.7116322251
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.7117474063
MESH:D002277 Carcinoma Methylcholanthrene 4.0110545420
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.843581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.843084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.467505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4612371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.4616192471
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.629022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.6219486331
MESH:D002779 Cholestasis pirinixic acid 13.6219176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711298694 2524372 8970840 8156756 11906362 18759878 14531868 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.767440962 6679447 18289764 9653073 16192314 18692083 9022650 9328219 1440618 8291058 6482804 11289319 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7618713872 16081117 12153990 11421492 16485898 19420014 15619225 15968718 19370779 19085960 2444490 16227642 17562736 12705907 11739529 14986274 11461765 16177239 14550746 17906064 11529661 18071297 12392966 11834606 19923254 12594235 12540782 10915739 19416960 16109766 11743745 12958197 16393943 11287661 10774834 17522070 10663392 19164858 14725611 19739265 16781746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005234 Fatty Liver Cyclosporine 7.7419224547
MESH:D005234 Fatty Liver pirinixic acid 7.7419236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0214633661 10962813
MESH:D005355 Fibrosis Cyclosporine 3.2112639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0718467677 19772884 16221962 19176532
MESH:D006561 Herpes Simplex Etoposide 4.6410809021
MESH:D006689 Hodgkin Disease Etoposide 3.9217606976 16135485 16200630 15147373 18180244
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.898314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.426582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6419460945 19784758 12587719 12969438 16611625 16610002 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8416377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.273712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.27598648 1399818
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.4017909032 16337739 10545420 9230183 21163286 20970405 6695378 16271038 20512841 7750092 1399818 15390079 11893704
MESH:D008223 Lymphoma Etoposide 3.9612556972 12854902
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008708 Methemoglobinemia Phenacetin 5.013537620 4834387 16296465 1949026
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.474026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Etoposide 3.2919003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Daunorubicin 4.8021297632
MESH:D011471 Prostatic Neoplasms Etoposide 4.0117172428
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012512 Sarcoma, Ewing's Etoposide 4.7714601052
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.65978859
MESH:D024801 Tauopathies Camptothecin 12.5016930453
MESH:D024801 Tauopathies Daunorubicin 12.5016930453
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.921399818 6587162 6582329 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.638074119
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 5.6311144890
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
KEGG:04012 ErbB signaling pathway
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:05130 Pathogenic Escherichia coli infection
REACT:16888 Signaling by PDGF
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31467
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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