AutismKB 2.0

Annotation Detail for CARD11


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Basic Information Top
Gene Symbol:CARD11 ( BIMP3,CARMA1,MGC133069 )
Gene Full Name: caspase recruitment domain family, member 11
Band: 7p22.2
Quick LinksEntrez ID:84433; OMIM: 607210; Uniprot ID:CAR11_HUMAN; ENSEMBL ID: ENSG00000198286; HGNC ID: 16393
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200005BCR signaling pathway
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
No data
Pathway IDPathway Name
500482Downstream TCR signaling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of CARD11 geneincreases mutagenesis 16724327
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Ethylnitrosourea 3.996695378
MESH:D001927 Brain Diseases Ethylnitrosourea 5.4614991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.8616436596 16651633 15144691 18412241 16357521
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 4.0816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 7.4017160924
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 7.4018357618
MESH:D005909 Glioblastoma Ethylnitrosourea 4.1516436596
MESH:D005910 Glioma Ethylnitrosourea 3.6516651633 18412241 16357521
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.4117379185
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6416271038 17703301 16019985 6695378
MESH:D008223 Lymphoma Ethylnitrosourea 4.3215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.9615375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.8310838139 18041768 10767621
MESH:D008579 Meningioma Ethylnitrosourea 7.4017943659
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 5.3116707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.5017160924 16003739 16651423
MESH:D009837 Oligodendroglioma Ethylnitrosourea 7.4017160924
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 6.2515790496
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26073
    • Releated gene ID Related gene Name
    PA26241CD83
    Releated disease ID Related disease Name
    PA160680212Lymphoma, Large B-Cell, Diffuse
    PA444840Lymphoma
    PA446304Lymphoma, B-Cell
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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