AutismKB 2.0

Annotation Detail for DYRK3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DYRK3 ( DYRK5,RED,REDK,hYAK3-2 )
Gene Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Band: 1q32.1
Quick LinksEntrez ID:8444; OMIM: 603497; Uniprot ID:DYRK3_HUMAN; ENSEMBL ID: ENSG00000143479; HGNC ID: 3094
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DYRK3 mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DYRK3 mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DYRK3 mRNAincreases expression 20382639
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DYRK3 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of DYRK3 mRNAincreases expression 19482888
C025643 vinclozolin vinclozolin results in decreased expression of DYRK3 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.223712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.226695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.5117620307
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.147296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1417173139 6705139 20007298 1701930 20935162
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.437505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4320889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4119486331 9022650
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.288970840 8156756 14531868 18759878 11906362 12868966 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.039328219 16192314 18692083 18648102 9022650 1440618 6482804 8291058 18289764 9653073 11289319 6679447 7440962
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.4811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.623581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6216530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006529 Hepatomegaly Phenobarbital 3.9716109766
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007248 Infertility, Male vinclozolin 3.2616467254
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008107 Liver Diseases Phenobarbital 2.2319363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9120195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 4.9119073162 21047994 19812893 15975961 19482888 8742319
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.631399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.6317172636 18308698 1399818 2563599 6150874
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718816296 20464547 18569708 18520028 6695378 20064080 17053015 20869020 20135361
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.4418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012640 Seizures Phenobarbital 2.9216876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.063712494 6582329 6587162 7505956 1399818
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.061399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.358074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3517053015
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved